Association Between Serum Ferritin Levels and Low Bone Mineral Density in Postmenopausal Osteoporosis Women

  • Lama ALjeshi Mail Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria.
  • Shaden Haddad Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria.
Ferritin, Iron, Bone mineral density, Osteoporosis, Postmenopausal women, Fracture


As women go through menopause, serum estrogen decreases, and ferritin increases. Ferritin is an essential component of the body, but many studies have stated that ferritin, which exceeds the normal physiological range, may potentially cause health problems in women. The aim of this study is to investigate the relationship between bone mineral density and serum ferritin levels in post-menopausal women and to evaluate serum ferritin levels as a potential biomarker for postmenopausal osteoporosis. Serum ferritin levels were measured in 62 postmenopausal women with low bone mineral density, and in 18 postmenopausal healthy control women using a standardized Enzyme-Linked Immune Sorbent Assay (ELISA) kit. Bone mineral density BMD was assessed at the lumbar spine and femoral neck. The mean serum ferritin level was significantly higher in the postmenopausal women with low BMD group (group 1) than in the normal control group (group 2), respectively (mean=262.69 vs. 181.44 ng/ml, (P<0.05), and serum ferritin level was negatively correlated with BMD among low BMD postmenopausal women's group (R= -0.628, P=0.0001), and in the healthy postmenopausal group (R= -0.052, P=0.838). A comparison of the BMD between spine and femur neck sites shows that the frequency of low BMD in the spine site is higher than the femur neck site. Our findings show that increased serum ferritin levels were associated with low bone mineral density in postmenopausal osteoporosis.


1. Lin JT, Lana JM. Osteoporosis: areview. 2004 Aug;(425):126-34. [PMID: 15292797]

2. Juliana M. Kling, B.L.C., and Nicole P. Sandhu. . Osteoporosis Prevention Screening and Treatment. journal of women’s health .vol. 23, number 7, 2014 . Available from: [ ] [PMID:24766381]
3. Proff P, Romer P. The molecular mechanism behind bone remodelling. Clin Oral Investig. 2009Dec;13(4):355-62 [Doi:10.1007/s00784-009-0268-2] [PMID: 19319579]

4. Nupur Kohli a, S.H.a., Stuart J. Brown a, Prasad Sawadkar a, Vaibhav Sharma a,Martyn Snowb, Elena García-Gareta a.Bone remodelling in vitro Where are we headed. Bone Volume 110, May 2018, Pages 38-46. []

5. Watts NB. Postmenopausal Osteoporosis a clinical review. J Womens Health (Larchmt). 2018 Sep;27(9):1093-1096. [DOI:10.1089/jwh.2017.6706] [PMID:29583083]

6. Qian Cheng, Xiaofei Zhang, Jun Jiang, Guoyang Zhao, Yin Wang, Youjia Xu, Ximing Xu, and Haile Ma.Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen. Hindawi,BioMed Research International. 2017; 2017: 1345193. [doi: 10.1155/2017/1345193] [PMID: 28620614 ]

7. Laura Toxqui and M. Pilar Vaquero .Chronic Iron Deficiency as an Emerging Risk Factor for Osteoporosis A Hypothesis. Nutrients. 2015 Apr; 7(4): 2324–2344. [doi: 10.3390/nu7042324] [PMID: 25849944]

8. Mary Ann Knovich, J.A.S., Lan G. Coffman,Suzy V.Torti. Ferritin for the Clinician. [doi: 10.1016/j.blre.2008.08.001] [PMID: 18835072]

9. Ahn SH, L.S., Kim H, Lee SH, Kim BJ, Koh JM. Higher serum ferritin level and lower femur neck strength in women at the stage of bone loss (≥ 45 years of age): The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV). Endocr Res. 2016 Nov;41(4):334-342. Epub 2016 Apr 4. [DOI: 10.3109/07435800.2016.1155600] [PMID: 27045342]

10. Jeney V.Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss. Front Pharmacol. 2017 Feb 21;8:77 [doi: 10.3389/fphar.2017.00077] [. PMID: 28270766]

11. Cristina Mariano Ruas BrandãoI; Marina Guimarães LimaII; Anderson Lourenço da SilvaII; Graziele Dias SilvaI; Augusto Afonso Guerra Jr.I; Francisco de Assis AcúrcioI. Treatment of postmenopausal osteoporosis in women: a systematic review. SciELO. vol.24. []
12. Seung Joo Chon, Y.R.C., Yun Ho Roh, Bo Hyon Yun, SiHyun Cho, and B.S.L. Young Sik Choi, Seok Kyo Seo.Association between Levels of Serum Ferritin and Bone Mineral Density in Korean Premenopausal and Postmenopausal. PLoS One. 2014 Dec 18;9(12):e114972. [doi:10.1371/journal.pone.0114972] [PMID:25522357]

accumulation A potential approach for the prevention and treatment of postmenopausal
osteoporosis. Exp Ther Med. 2015 Jul; 10(1): 7–1 [doi: 10.3892/etm.2015.2484] [PMID: 26170904]

14. Mansour Babaei, Ali Bijani, Parnaz Heidari, Seyyed Reza Hosseini, and Behzad Heidari,. Serum ferritin levels and bone mineral density. Caspian J Intern Med. 2018 Summer; 9(3): 232–238. [doi: 10.22088/cjim.9.3.232] [PMID: 30197767]

15. Lee KS, Bae SH, Lee SH, Lee J, Lee DR. New Reference Data on Bone ‎Mineral Density and the Prevalence of Osteoporosis in Korean Adults Aged 50 ‎Years or OlderThe Korea National Health and Nutrition Examination Survey 2008 ‎‎2010. J Korean Med Sci. 2014 Nov;29(11):1514-22. [doi: 10.3346/jkms.2014.29.11.1514] [PMID: 25408583]

16. Cheng XG, Yang DZ, Zhou Q, Zhuo TJ, Zhang HC, Xiang J, Wang HF, Ou PZ, Liu JL, Xu L, Huang GY, Huang QR, Barden HS, Weyn and LS, Faulkner KG, Meng XW. Age-related bone mineral density, bone loss rate, prevalence of osteoporosis, and reference database of women at multiple centers in China. J Clin Densitom. 2007 Jul-Sep;10(3):276-84. [DOI: 10.1016/j.jocd.2007.05.004] [PMID: 17604665 ]
17. Mehrdad Aghaei, Hamid Reza Bazr Afshan, Mostafa Qorbani, Hossien Shadpour Dashti, Roya Safari. Bone mineral density in Iranian patients Effects of age sex and body mass index. Open Journal of Preventive Medicine. Vol.3 No.1, February 2013. [DOI: 10.4236/ojpm.2013.31016]
How to Cite
ALjeshi L, Haddad S. Association Between Serum Ferritin Levels and Low Bone Mineral Density in Postmenopausal Osteoporosis Women. Acta Med Iran. 57(12):714-719.