Lower Circulating Levels of Soluble TNF-Like Weak Inducer of Apoptosis and Chromium in Treated Brucella Infection
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Abstract
Brucellosis is a common infectious disease around the globe. The aim of the present investigation was to evaluate the effect of brucellosis on the serum levels of chromium (Cr), lead (Pb), soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) as well as high-sensitivity C-reactive protein (hs-CRP) and homocysteine in patients suffering from brucellosis. The present case-control study was executed on 40 treated brucellosis patients (case) and 40 healthy individuals (control). Blood samples were obtained from all the participants for the measurement of the desired indices. The serum levels of chromium in the case group (0.109±0.025 μg/L) was significantly lower compared with that in the control group (0.121±0.027 μg/L, P=0.047). The levels of lead in serum were almost unchanged between the two groups (12.58±1.94 vs. 12.28±2.42 μg/dL, P=0.533). The sTWEAK levels were significantly lower in the case group as compared to the control subjects (235.20±48.45 pg/mL vs. 262.00±67.25 pg/mL, P=0.044). The levels of hs-CRP were significantly higher in the case group (2.23±0.34 mg/L) than that in the control group (2.05±0.32 mg/L, P=0.016); similarly, homocysteine levels were higher in the serum of patients in case group as compared to the control ones (16.18±4.47 µmol/L vs. 14.36±3.06 µmol/L, P=0.038). The current investigation underlined that brucellosis causes alterations in serum chromium and sTWEAK levels, the markers that are considered as the predictors of cardiovascular disease.
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2. Mirnejad R, Jazi FM, Mostafaei S, Sedighi M. Epidemiology of brucellosis in Iran: A comprehensive
systematic review and meta-analysis study. Microb Pathog 2017;109:239-47.
3. Meltzer E, Sidi Y, Smolen G, Banai M, Bardenstein S, Schwartz E. Sexually transmitted brucellosis in humans. Clin Infect Dis 2010;51: 12-5.
4. Ulu Kilic A, Metan G, Alp E. Clinical presentations and diagnosis of brucellosis. Recent Patents on Anti-infective Drug Discovery 2013;8:34-41.
5. Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, et al. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. Biomed Res Int 2018;2018:5712920.
6. Vendrell JJ, R Chacon M. TWEAK: a new player in obesity and diabetes. Front Immunol 2013;4:488.
7. Muñoz-García Ba, Moreno JA, López-Franco O, Sanz ABn, Martín-Ventura JL, Blanco J, et al. Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice. Arterioscler Throm Vasc Biol 2009;29:2061-8.
8. Chicheportiche Y, Bourdon PR, Xu H, Hsu Y-M, Scott H, Hession C, et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem 1997;272:32401-10.
9. Askarian F, Ghorbanihaghjo A, Argani H, Sanajou D, Nasehi N, Askarian R, et al. Soluble Tumor Necrosis Factor Like Weak Inducer of Apoptosis and Vitamin D in Hemodialysis Patients: Relation to Carotid Intima-Media Thickness. Indian J Clin Biochem 2018;33:297-303.
10. Blanco-Colio LM, Martín-Ventura JL, Muñóz-García Ba, Orbe J, Páramo JA, Michel J-B, et al. Identification of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) as a possible biomarker of subclinical atherosclerosis. Arterioscler Throm Vasc Biol 2007;27:916-22.
11. Dirajlal-Fargo S, Sattar A, Kulkarni M, Funderburg N, McComsey GA. Soluble TWEAK may predict carotid atherosclerosis in treated HIV infection. HIV Clin Trials 2017;18:156-63.
12. Bozic M, Méndez-Barbero N, Gutiérrez-Muñoz C, Betriu A, Egido J, Fernández E, et al. Combination of biomarkers of vascular calcification and sTWEAK to predict cardiovascular events in chronic kidney disease. Atherosclerosis 2018;270:13-20.
13. Chen S, Jin X, Shan Z, Li S, Yin J, Sun T, et al. Inverse association of plasma chromium levels with newly diagnosed type 2 diabetes: A case-control study. Nutrients 2017;9:294.
14. Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. Lead exposure and cardiovascular disease a systematic review. Environ Health Perspect 2006;115:472-82.
15. Carver PL. Metal ions and infectious diseases. An overview from the Interrelations between Essential Metal Ions and Human Diseases. Berlin, Germany: Springer, 2013:1-28.
16. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson L, Loscalzo J. Harrison's Principles of Internal Medicine. 19th. Amsterdam, Netherlands: Elsevier, 2015.
17. Kazemi S, Saidijam M, Hashemi SH, Karami M, Vaisi-Raygani A, Alikhani MY. Analysis of IL-10 and IL-6 gene polymorphisms and their serum levels in patients with brucellosis: a case control study. Immunol Invest 2016;45:107-15.
18. Togan T, Narci H, Turan H, Ciftci O, Kursun E, Arslan H. The impact of acute brucellosis on mean platelet volume and red blood cell distribution. Jundishapur J Microbiol 2015;8:e20039.
19. Houtman JP. Trace elements and cardiovascular diseases. J Cardiovas Risk 1996;3:18-24.
20. Prashanth L, Kattapagari KK, Chitturi RT, Baddam VRR, Prasad LK. A review on role of essential trace elements in health and disease. Journal of Dr. NTR University of Health Sciences 2015;4:75-80.
21. Hua Y, Clark S, Ren J, Sreejayan N. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem 2012;23:313-19.
22. Mobaien A, Hajiabdolbaghi M, Jafari S, Alipouran A, Ahmadi M, Eini P, et al. Serum zinc and copper concentrations in brucellosis patient. Arch Clin Infect Dis 2010;5:96-100.
23. Zanganeh N, Siahpoushi E, Kheiripour N, Kazemi S, Goodarzi MT, Alikhani MY. Brucellosis causes alteration in trace elements and oxidative stress factors. Biol Trace Elem Res 2018;182:204-8.
24. Festus O, Ekun V, Dada F, Eidangbe G, Iweka F. Evaluation of some trace elements (zinc, chromium,
cadmium and manganese) in patients with active tuberculosis attending central hospital Benin city, Edo state. Int J Basic Appl Innovat Res 2016;5:35-41.
25. Afridi HI, Kazi TG, Talpur FN, Arain S, Arain SS, Kazi N, et al. Evaluation of chromium and manganese in biological samples (scalp hair, blood and urine) of tuberculosis and diarrhea male human immunodeficiency virus patients. Clin Lab 2014;60:1333-41.
26. Ganguly R, Sahu S, Ohanyan V, Haney R, Chavez RJ, Shah S, et al. Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE−/− mice. Sci Rep 2017;7:452794.
27. Davies S, Howard JM, Hunnisett A, Howard M. Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients—implications for the prevention of cardiovascular disease and type II diabetes mellitus. Metabolism 1997;46:469-73.
28. Togan T, Ciftci O, Turan H, Narci H, Gullu H, Arslan H. Could there be an association between chronic brucellosis and endothelial damage? J Infect Develop Count 2015;9: 48-54.
29. Fernández-Laso V, Méndez-Barbero N, Valdivielso JM, Betriu A, Fernández E, Egido J, et al. Soluble TWEAK and atheromatosis progression in patients with chronic kidney disease. Atherosclerosis 2017;260:130-7.
30. Beltrán LM, Hernández RM, de Pablo Bernal RS, Morillo JSG, Egido J, Noval ML, et al. Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection. PLoS One 2014;9:90541.
31. Tang Y, Liang P, Chen J, Fu S, Liu B, Feng M, et al. The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population. Immun Ageing 2018;15:21-8.
2. Mirnejad R, Jazi FM, Mostafaei S, Sedighi M. Epidemiology of brucellosis in Iran: A comprehensive
systematic review and meta-analysis study. Microb Pathog 2017;109:239-47.
3. Meltzer E, Sidi Y, Smolen G, Banai M, Bardenstein S, Schwartz E. Sexually transmitted brucellosis in humans. Clin Infect Dis 2010;51: 12-5.
4. Ulu Kilic A, Metan G, Alp E. Clinical presentations and diagnosis of brucellosis. Recent Patents on Anti-infective Drug Discovery 2013;8:34-41.
5. Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, et al. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. Biomed Res Int 2018;2018:5712920.
6. Vendrell JJ, R Chacon M. TWEAK: a new player in obesity and diabetes. Front Immunol 2013;4:488.
7. Muñoz-García Ba, Moreno JA, López-Franco O, Sanz ABn, Martín-Ventura JL, Blanco J, et al. Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice. Arterioscler Throm Vasc Biol 2009;29:2061-8.
8. Chicheportiche Y, Bourdon PR, Xu H, Hsu Y-M, Scott H, Hession C, et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem 1997;272:32401-10.
9. Askarian F, Ghorbanihaghjo A, Argani H, Sanajou D, Nasehi N, Askarian R, et al. Soluble Tumor Necrosis Factor Like Weak Inducer of Apoptosis and Vitamin D in Hemodialysis Patients: Relation to Carotid Intima-Media Thickness. Indian J Clin Biochem 2018;33:297-303.
10. Blanco-Colio LM, Martín-Ventura JL, Muñóz-García Ba, Orbe J, Páramo JA, Michel J-B, et al. Identification of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) as a possible biomarker of subclinical atherosclerosis. Arterioscler Throm Vasc Biol 2007;27:916-22.
11. Dirajlal-Fargo S, Sattar A, Kulkarni M, Funderburg N, McComsey GA. Soluble TWEAK may predict carotid atherosclerosis in treated HIV infection. HIV Clin Trials 2017;18:156-63.
12. Bozic M, Méndez-Barbero N, Gutiérrez-Muñoz C, Betriu A, Egido J, Fernández E, et al. Combination of biomarkers of vascular calcification and sTWEAK to predict cardiovascular events in chronic kidney disease. Atherosclerosis 2018;270:13-20.
13. Chen S, Jin X, Shan Z, Li S, Yin J, Sun T, et al. Inverse association of plasma chromium levels with newly diagnosed type 2 diabetes: A case-control study. Nutrients 2017;9:294.
14. Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. Lead exposure and cardiovascular disease a systematic review. Environ Health Perspect 2006;115:472-82.
15. Carver PL. Metal ions and infectious diseases. An overview from the Interrelations between Essential Metal Ions and Human Diseases. Berlin, Germany: Springer, 2013:1-28.
16. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson L, Loscalzo J. Harrison's Principles of Internal Medicine. 19th. Amsterdam, Netherlands: Elsevier, 2015.
17. Kazemi S, Saidijam M, Hashemi SH, Karami M, Vaisi-Raygani A, Alikhani MY. Analysis of IL-10 and IL-6 gene polymorphisms and their serum levels in patients with brucellosis: a case control study. Immunol Invest 2016;45:107-15.
18. Togan T, Narci H, Turan H, Ciftci O, Kursun E, Arslan H. The impact of acute brucellosis on mean platelet volume and red blood cell distribution. Jundishapur J Microbiol 2015;8:e20039.
19. Houtman JP. Trace elements and cardiovascular diseases. J Cardiovas Risk 1996;3:18-24.
20. Prashanth L, Kattapagari KK, Chitturi RT, Baddam VRR, Prasad LK. A review on role of essential trace elements in health and disease. Journal of Dr. NTR University of Health Sciences 2015;4:75-80.
21. Hua Y, Clark S, Ren J, Sreejayan N. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem 2012;23:313-19.
22. Mobaien A, Hajiabdolbaghi M, Jafari S, Alipouran A, Ahmadi M, Eini P, et al. Serum zinc and copper concentrations in brucellosis patient. Arch Clin Infect Dis 2010;5:96-100.
23. Zanganeh N, Siahpoushi E, Kheiripour N, Kazemi S, Goodarzi MT, Alikhani MY. Brucellosis causes alteration in trace elements and oxidative stress factors. Biol Trace Elem Res 2018;182:204-8.
24. Festus O, Ekun V, Dada F, Eidangbe G, Iweka F. Evaluation of some trace elements (zinc, chromium,
cadmium and manganese) in patients with active tuberculosis attending central hospital Benin city, Edo state. Int J Basic Appl Innovat Res 2016;5:35-41.
25. Afridi HI, Kazi TG, Talpur FN, Arain S, Arain SS, Kazi N, et al. Evaluation of chromium and manganese in biological samples (scalp hair, blood and urine) of tuberculosis and diarrhea male human immunodeficiency virus patients. Clin Lab 2014;60:1333-41.
26. Ganguly R, Sahu S, Ohanyan V, Haney R, Chavez RJ, Shah S, et al. Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE−/− mice. Sci Rep 2017;7:452794.
27. Davies S, Howard JM, Hunnisett A, Howard M. Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients—implications for the prevention of cardiovascular disease and type II diabetes mellitus. Metabolism 1997;46:469-73.
28. Togan T, Ciftci O, Turan H, Narci H, Gullu H, Arslan H. Could there be an association between chronic brucellosis and endothelial damage? J Infect Develop Count 2015;9: 48-54.
29. Fernández-Laso V, Méndez-Barbero N, Valdivielso JM, Betriu A, Fernández E, Egido J, et al. Soluble TWEAK and atheromatosis progression in patients with chronic kidney disease. Atherosclerosis 2017;260:130-7.
30. Beltrán LM, Hernández RM, de Pablo Bernal RS, Morillo JSG, Egido J, Noval ML, et al. Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection. PLoS One 2014;9:90541.
31. Tang Y, Liang P, Chen J, Fu S, Liu B, Feng M, et al. The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population. Immun Ageing 2018;15:21-8.
| Files | ||
| Issue | Vol 57, No 9 (2019) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/acta.v57i9.2639 | |
| Keywords | ||
| Brucellosis Chromium Lead Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) | ||
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How to Cite
1.
Mohsenpour Azari M, Golestani Eimani B, Entezarmahdi R. Lower Circulating Levels of Soluble TNF-Like Weak Inducer of Apoptosis and Chromium in Treated Brucella Infection. Acta Med Iran. 2020;57(9):549-553.
