Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis

  • Parvaneh Deilami Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Shadi Ghourchian Deprtment of Neurology, School of Medicine, University of Maryland, Baltimore, MD, US.
  • Bahram Haghi Ashtiani Mail Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  • Sara Esmaeili Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  • Maryam Bahadori Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Seyedeh Fahimeh Shojaei Department of Psychiatry, Firoozgar Clinical Research and Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran,
  • Mohammad Reza Babaei Department of Interventional Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Leila Raeesmohammadi Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Motahare Afrakhteh Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Babak Zamani Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Keywords:
Amyotrophic lateral sclerosis (ALS), Median nerve, Cross-sectional area, Compound muscle action potential (CMAP), ALS functional rating scale (ALSFRS)

Abstract

We aimed to compare the sonographic measurement of median nerve cross-section area (CSA) in patients with Amyotrophic Lateral Sclerosis (ALS) and healthy individuals. The effect of duration of the disease on correlations between paraclinical findings and ALS functional rating scale (ALSFRS) were secondarily aimed to be evaluated. The cross-sectional study was approved by the Ethical Committee of Iran University of Medical Sciences and conducted between January 2017 and December 2018. We evaluated the median nerve surface area by means of sonography in 35 ALS patients and 35 healthy controls. Compound muscle action potential (CMAP) amplitudes during nerve conduction study and ALSFRS were recorded by the same trained specialist. Data were analyzed using SPSS software version 18. We did not find a significant difference between CSA in ALS patients and the normal population (P>0.05). Comparing to normal individuals, the mean CMAP decreased significantly in ALS patients (6.6±3.07 mV versus 10.25±2.2 mV, P<0.001). ALSFRS correlated with both CSA of the median nerve at the wrist (P:<0.001, r:0.78) and the CMAP (P:<0.001, r:0.74) that were confirmed by regression models designed to consider the effect of disease duration on these correlations. CSA was not different between ALS patients and the normal population, but CMAP decreased in ALS patients. ALSFRS correlated with both CSA and CMAP of the median nerve.

Published
2020-05-13
How to Cite
1.
Deilami P, Ghourchian S, Haghi Ashtiani B, Esmaeili S, Bahadori M, Shojaei SF, Babaei MR, Raeesmohammadi L, Afrakhteh M, Zamani B. Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis. Acta Med Iran. 57(11):658-662.
Section
Articles