Clinico-Laboratory Profile of Dengue Patients at Sir T. Hospital, Bhavnagar, India

  • Nilesh D. Patel Department of Microbiology, Government Medical College, Bhavnagar, Gujarat, India.
  • Kairavi J. Desai Mail Department of Microbiology, Government Medical College, Bhavnagar, Gujarat, India .
  • Jatin Sarvaiya Department of Microbiology, Government Medical College, Bhavnagar, Gujarat, India.
  • Saqlain Malek Department of Microbiology, Government Medical College, Bhavnagar, Gujarat, India.
Clinical presentation, Dengue, Laboratory tests


Dengue fever is caused by any one of four types of dengue viruses (DEN1-DEN4), spread mainly by Aedes aegypti. India had the largest number of dengue cases, with about 33 million apparent and another 100 million asymptomatic infections occurring annually. The patients typically present with the sudden onset of fever, frontal headache, retroorbital pain. The laboratory diagnosis can be made by IgM ELISA or by NS1 antigen-detection ELISA during the acute phase. This research was conducted from January 2018 to December 2018 at Sir T. hospital and Government Medical College in Bhavnagar, Gujarat. The patients having complaints of fever, headache, myalgia, arthralgia or rash, were clinically examined, and laboratory investigated for dengue with NS1 and/or IgM dengue antibody. A total of 536 patients was screened, of which 112 patients were diagnosed as dengue fever at 21% dengue positivity rate, based on detection of NS1 (46/304, 15%), and anti-dengue IgM (66/232, 28%) in their sera. The majority of the patients were males (77/112, 69%). The majority of patients were in 11–30 years’ age group (66/316, 21%). Fever (100%) was the chief presenting complaint, followed by headache (83, 93%), and myalgia (79, 89%). The highest number (28) of dengue patients was observed in the month of October 2018. According to this study results, the physicians in the dengue-endemic area should be aware of dengue in acute febrile illnesses and use the appropriate laboratory tests such as NS1 antigen and IgM antibodies for early dengue diagnosis. This can help clinicians to prevent morbidity and mortality associated with dengue.


1. Bhatt S, Gething PW, Brady OJ, et al. The global distribution and burden of dengue. Nature. 2013; 496: 504–507.
2. Dengue Fever. Mayo Clinic. Last accessed on 10 April 2019.
3. WHO (2011). Comprehensive guidelines for prevention and control of dengue and dengue hemorrhagic fever, revised and expanded edition, SEAR.
4. Kuhn JH, Peters CJ. Arthropod-borne and rodent-borne virus infections. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s Principles of Internal Medicine. 19th ed. Volume 2. McGraw-Hill Education; Columbus, OH, USA: 2015. pp. 1304–23.
5. Vaidya R. Ischaemic Heart Disease (IHD). In: Bhalwar R, Vaidya R, Tilak R, Gupta R, Kunte R. Text Book of Public Health and Community Medicine. 1st ed. New Delhi: Department of Community Medicie, AFMC, Pune; 2009: 1040–3.
6. Kelly JD, Shandera WX. Viral and Rickettsial Infections. In: Papadakis MA, McPhee SJ, Rabow MW, editors. 2016: Current Medical Diagnosis and Treatment. 55th ed. McGraw-Hill Education; New York: 2016.pp. 1342-416.
7. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998; 11:480–96.
8. India, Ministry of Health and Family Welfare. National Vector Borne Disease Control Programme. New Delhi: Directorate General of Health Services; 2019. Available from: [Last accessed on 9 April 2019].
9. Ramana KV. Dengue viral infection: Focus on epidemiology, laboratory diagnosis, management and control measures. J Appl Environ Microbiol 2014;2:249‑52.
10. Clinical Spectrum and Laboratory Profile of Patients with Dengue Fever in a Tertiary Care Centre of Eastern UP, India- An Observational Study. Ravindu et al. JAM– 6(1): 1-7, June 2017.
11. Chakravarti A, Roy P, Malik S, Siddiqui O, Thakur P. A study on gender-related differences in laboratory characteristics of dengue fever. Indian J Med Microbiol 2016;34:82-4.
12. Guha‑Sapir D, Schimmer B. Dengue fever: New paradigms for a changing epidemiology. Emerg Themes Epidemiol 2005;2:1.
13. Sreenivasulu T et al. Int J Adv Med. 2018 Feb;5(1):202-206.
14. Dengue. WHO. (Last accessed on 10 April 2019)
15. Srikiatkhachorn A, Gibbons RV, Green S, Libraty DH, Thomas SJ, et al. Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. Clin Infect Dis 2010; 50:1135–1143.
16. Mohan D K, Shiddappa, Dhananjaya M. A Study of Clinical Profile of Dengue Fever in a Tertiary Care Teaching Hospital. Sch J App Med Sci 2013; 1:280-282.
17. Rachel D, Rajamohanan, Philip AZ. A Study of Clinical Profile of Dengue Fever in Kollam, Kerala, India. Dengue Bulletin 2005; 29:197-202.
18. Munde DD, Shetkar UB. Clinical Features and Haematological Profile of Dengue Fever. Indian J Appl Res 2013; 3:131-132.
19. Mandal SK, Ganguly J, Koelina Sil et al. Clinical profiles of dengue fever in a teaching hospital of eastern india. Nat J Med Res 2013; 3:173-176.
20. Chandy S, Ramanathan K, Manoharan A, Mathai D, Baruah K (2013) Assessing effect of climate on the incidence of dengue in Tamil Nadu. Indian J Med Microbiol 31: 283-286.
21. Neeraja M, Lakshmi V, Teja VD, Umabala P, Subbalakshmi MV (2006) Serodiagnosis of dengue virus infection in patients presenting to a tertiary care hospital. Indian J Med Microbiol 24: 280-282.
22. National Centre for Disease Control Newsletter (2013) Quarterly newsletter from the national centre for disease control (NCDC).
How to Cite
Patel N, Desai K, Sarvaiya J, Malek S. Clinico-Laboratory Profile of Dengue Patients at Sir T. Hospital, Bhavnagar, India. Acta Med Iran. 58(2):69-72.