Unsolved Mystery of Synchronous Metastatic Adenocarcinoma and Echinococcus Cystic Infection, a Major Break Through in Clinical Oncology: A Case Report
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Abstract
Echinococcus cystic infection is a zoonotic infection caused by the larval stage of cestode species belonging to the genus Echinococcus. Through the modulation of the immune system by this parasite, there is an established link of this infection with the metastasis and progression of a tumor. We present a case of a patient with synchronous findings of metastatic adenocarcinoma with unknown primary along with the previous history of echinococcal infection which highlights the need of prompt management of such infections with a regular follow up of such patients.
1. Ali R, Ozkalemkas F, Ozkocaman V, Ozcelik T, Akalin H, Ozkan A, Altundal Y, Tunali A. Hydatid disease in acute leukemia: effect of anticancer treatment on echinococcosis. Microbes and infection. 2005 Jul 1;7(9-10):1073-6.
2. Zöld É, Barta Z, Zeher M. Hydatid disease of the liver and associated hepatocellular carcinoma. Clinical Gastroenterology and Hepatology. 2005 Aug 1;3(8):A35.
3. Gungor T, Altinkaya SO, Sirvan L, Lafuente RA, Ceylaner S. Coexistence of borderline ovarian epithelial tumor, primary pelvic hydatid cyst, and lymphoepithelioma-like gastric carcinoma. Taiwanese Journal of Obstetrics and Gynecology. 2011 Jun 1;50(2):201-4.
4. Craig PS, Rogan MT, Campos-Ponce M. Echinococcosis: disease, detection and transmission. Parasitology. 2003 Oct;127(S1):S5-20.
5. Eckert J, Deplazes P. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clinical microbiology reviews. 2004 Jan 1;17(1):107-35.
6. Petri A, Karacsonyi S, Kalmar NK, Leindler L. Surgical management of liver echinococcosis. Orvosi hetilap. 1993 Jul;134(27):1465-8.
7. Baldus SE, Engelmann K, Hanisch FG. MUC1 and the MUCs: a family of human mucins with impact in cancer biology. Critical reviews in clinical laboratory sciences. 2004 Jan 1;41(2):189-231.
8. Thomas PG, Harn Jr DA. Immune biasing by helminth glycans. Cellular microbiology. 2004 Jan;6(1):13-22.
9. Ubillos L, Medeiros A, Cancela M, Casaravilla C, Saldaña J, Domínguez L, Carmona C, Le Pendu J, Osinaga E. Characterization of the carcinoma-associated Tk antigen in helminth parasites. Experimental parasitology. 2007 Jun 1;116(2):129-36.
10. Dar FK, Buhidma MA, Kidwai SA. Hydatid false positive serological test results in malignancy. British medical journal (Clinical research ed.). 1984 Apr 21;288(6425):1197.
11. Pfister M, Gottstein B, Cerny T, Cerny A. Immunodiagnosis of echinococcosis in cancer patients. Clinical microbiology and infection. 1999 Nov;5(11):693-7.
12. Reiche EM, Nunes SO, Morimoto HK. Stress, depression, the immune system, and cancer. The lancet oncology. 2004 Oct 1;5(10):617-25.
13. Stadelmann B, Spiliotis M, Müller J, Scholl S, Müller N, Gottstein B, Hemphill A. Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite–host cell interactions. International journal for parasitology. 2010 Nov 1;40(13):1563-74.
14. Yanagawa T, Funasaka T, Tsutsumi S, Watanabe H, Raz A. Novel roles of the autocrine motility factor/phosphoglucose isomerase in tumor malignancy. Endocrine-Related Cancer. 2004 Dec 1;11(4):749-59.
2. Zöld É, Barta Z, Zeher M. Hydatid disease of the liver and associated hepatocellular carcinoma. Clinical Gastroenterology and Hepatology. 2005 Aug 1;3(8):A35.
3. Gungor T, Altinkaya SO, Sirvan L, Lafuente RA, Ceylaner S. Coexistence of borderline ovarian epithelial tumor, primary pelvic hydatid cyst, and lymphoepithelioma-like gastric carcinoma. Taiwanese Journal of Obstetrics and Gynecology. 2011 Jun 1;50(2):201-4.
4. Craig PS, Rogan MT, Campos-Ponce M. Echinococcosis: disease, detection and transmission. Parasitology. 2003 Oct;127(S1):S5-20.
5. Eckert J, Deplazes P. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clinical microbiology reviews. 2004 Jan 1;17(1):107-35.
6. Petri A, Karacsonyi S, Kalmar NK, Leindler L. Surgical management of liver echinococcosis. Orvosi hetilap. 1993 Jul;134(27):1465-8.
7. Baldus SE, Engelmann K, Hanisch FG. MUC1 and the MUCs: a family of human mucins with impact in cancer biology. Critical reviews in clinical laboratory sciences. 2004 Jan 1;41(2):189-231.
8. Thomas PG, Harn Jr DA. Immune biasing by helminth glycans. Cellular microbiology. 2004 Jan;6(1):13-22.
9. Ubillos L, Medeiros A, Cancela M, Casaravilla C, Saldaña J, Domínguez L, Carmona C, Le Pendu J, Osinaga E. Characterization of the carcinoma-associated Tk antigen in helminth parasites. Experimental parasitology. 2007 Jun 1;116(2):129-36.
10. Dar FK, Buhidma MA, Kidwai SA. Hydatid false positive serological test results in malignancy. British medical journal (Clinical research ed.). 1984 Apr 21;288(6425):1197.
11. Pfister M, Gottstein B, Cerny T, Cerny A. Immunodiagnosis of echinococcosis in cancer patients. Clinical microbiology and infection. 1999 Nov;5(11):693-7.
12. Reiche EM, Nunes SO, Morimoto HK. Stress, depression, the immune system, and cancer. The lancet oncology. 2004 Oct 1;5(10):617-25.
13. Stadelmann B, Spiliotis M, Müller J, Scholl S, Müller N, Gottstein B, Hemphill A. Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite–host cell interactions. International journal for parasitology. 2010 Nov 1;40(13):1563-74.
14. Yanagawa T, Funasaka T, Tsutsumi S, Watanabe H, Raz A. Novel roles of the autocrine motility factor/phosphoglucose isomerase in tumor malignancy. Endocrine-Related Cancer. 2004 Dec 1;11(4):749-59.
| Files | ||
| Issue | Vol 58, No 3 (2020) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/acta.v58i3.3778 | |
| Keywords | ||
| Echinococcuscystic infection Immune modulation Metastasis | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Ubaid A, Waheed F, Naeem A. Unsolved Mystery of Synchronous Metastatic Adenocarcinoma and Echinococcus Cystic Infection, a Major Break Through in Clinical Oncology: A Case Report. Acta Med Iran. 2020;58(3):134-137.
