Association of ADAM33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran
-
Mir Reza Ghaemi
,
Sara Hemmati
,
Arezou Rezaei
,
Maryam Sadr
,
Bahareh Mohebbi
,
Hosseinali Ghaffaripour
,
Nima Rezaei
,
Seyed Alireza Mahdaviani
Abstract
There is strong evidence on the interaction of several genetic variations and environmental conditions in the etiology of asthma. Association of a disintegrin and metalloproteinase 33 (ADAM33) with asthma risk is not clear and shows diversity between nations and ethnicities. Several single nucleotide polymorphisms (SNP) of the ADAM33 gene are introduced and studied according to the disease onset and characteristics. The aim of our study is to determine the association of ADAM33 rs2280091 polymorphism and pediatric asthma in the Iranian population. A total of 63 asthma patients (aged 6-18) and 86 healthy controls were enrolled in our study. Asthma type, classification, and severity were defined. SNPs of the ADAM33 gene at rs2280091 (T1) were analyzed. Pulmonary function tests, total blood eosinophil count, and IgE count were also assessed. T1 genotype and allele frequencies were not associated with asthma risk in Iranian pediatric asthma. Atopic asthma subgroup and patients with normal eosinophil count showed association with ADAM33 rs2280091. Moreover, asthma patients with AG genotype showed lower pulmonary functions.
1. Chhabra, S.K., Clinical application of spirometry in asthma: Why, when and how often? Lung India : official organ of Indian Chest Society, 2015. 32(6): p. 635-637.
2. Tran, T.N., et al., High blood eosinophil count is associated with more frequent asthma attacks in asthma patients. Ann Allergy Asthma Immunol, 2014. 113(1): p. 19-24.
3. Sengler, C., et al., Interactions between genes and environmental factors in asthma and atopy: new developments. Respiratory Research, 2001. 3(1): p. 7.
4. Nelson, H.S., et al., Airway remodeling in asthma: New insights. Journal of Allergy and Clinical Immunology, 2003. 111(2): p. 215-225.
5. Van Eerdewegh, P., et al., Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature, 2002. 418: p. 426.
6. Black, R.A. and J.M. White, ADAMs: focus on the protease domain. Current Opinion in Cell Biology, 1998. 10(5): p. 654-659.
7. Haitchi, H.M., et al., ADAM33 expression in asthmatic airways and human embryonic lungs. Am J Respir Crit Care Med, 2005. 171(9): p. 958-65.
8. Wang, X., et al., Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. BMC medical genetics, 2009. 10: p. 132-132.
9. Mahesh, P.A., Unravelling the role of ADAM 33 in asthma. The Indian journal of medical research, 2013. 137(3): p. 447-450.
10. Lee, J.H., et al., ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004. 34(6): p. 860-5.
11. Werner, M., et al., Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy, 2004. 34(1): p. 26-31.
12. Lind, D.L., et al., ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003. 168(11): p. 1312-6.
13. Sun, F.J., et al., Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017. 50(10): p. e6148-e6148.
14. Sambrook, J. and D.W. Russell, Purification of nucleic acids by extraction with phenol:chloroform. CSH Protoc, 2006. 2006(1).
15. El-Falaki, M.M., et al., A disintegrin and metalloproteinase 33 (ADAM33) gene polymorphism association with asthma in Egyptian children. Egyptian Journal of Medical Human Genetics, 2013. 14(1): p. 55-62.
16. Cakebread, J.A., et al., The role of ADAM33 in the pathogenesis of asthma. Springer Semin Immunopathol, 2004. 25(3-4): p. 361-75.
17. Foley, S.C., et al., Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007. 119(4): p. 863-71.
18. Sabar, M.F., et al., Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan. J Asthma, 2016. 53(4): p. 341-8.
19. Zhu, S., et al., Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia. Saudi Journal of Biological Sciences, 2018. 25(8): p. 1795-1799.
20. Deng, R., F. Zhao, and X. Zhong, T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians. Inflamm Res, 2017. 66(5): p. 413-424.
21. Howard, T.D., et al., Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. Journal of Allergy and Clinical Immunology, 2003. 112(4): p. 717-722.
22. Vergara, C.I., et al., A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia. International archives of allergy and immunology, 2010. 152(1): p. 32-40.
23. Jongepier, H., et al., Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy, 2004. 34(5): p. 757-60.
24. van Diemen, C.C., et al., A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. Am J Respir Crit Care Med, 2005. 172(3): p. 329-33.
2. Tran, T.N., et al., High blood eosinophil count is associated with more frequent asthma attacks in asthma patients. Ann Allergy Asthma Immunol, 2014. 113(1): p. 19-24.
3. Sengler, C., et al., Interactions between genes and environmental factors in asthma and atopy: new developments. Respiratory Research, 2001. 3(1): p. 7.
4. Nelson, H.S., et al., Airway remodeling in asthma: New insights. Journal of Allergy and Clinical Immunology, 2003. 111(2): p. 215-225.
5. Van Eerdewegh, P., et al., Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature, 2002. 418: p. 426.
6. Black, R.A. and J.M. White, ADAMs: focus on the protease domain. Current Opinion in Cell Biology, 1998. 10(5): p. 654-659.
7. Haitchi, H.M., et al., ADAM33 expression in asthmatic airways and human embryonic lungs. Am J Respir Crit Care Med, 2005. 171(9): p. 958-65.
8. Wang, X., et al., Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. BMC medical genetics, 2009. 10: p. 132-132.
9. Mahesh, P.A., Unravelling the role of ADAM 33 in asthma. The Indian journal of medical research, 2013. 137(3): p. 447-450.
10. Lee, J.H., et al., ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004. 34(6): p. 860-5.
11. Werner, M., et al., Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy, 2004. 34(1): p. 26-31.
12. Lind, D.L., et al., ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003. 168(11): p. 1312-6.
13. Sun, F.J., et al., Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017. 50(10): p. e6148-e6148.
14. Sambrook, J. and D.W. Russell, Purification of nucleic acids by extraction with phenol:chloroform. CSH Protoc, 2006. 2006(1).
15. El-Falaki, M.M., et al., A disintegrin and metalloproteinase 33 (ADAM33) gene polymorphism association with asthma in Egyptian children. Egyptian Journal of Medical Human Genetics, 2013. 14(1): p. 55-62.
16. Cakebread, J.A., et al., The role of ADAM33 in the pathogenesis of asthma. Springer Semin Immunopathol, 2004. 25(3-4): p. 361-75.
17. Foley, S.C., et al., Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007. 119(4): p. 863-71.
18. Sabar, M.F., et al., Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan. J Asthma, 2016. 53(4): p. 341-8.
19. Zhu, S., et al., Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia. Saudi Journal of Biological Sciences, 2018. 25(8): p. 1795-1799.
20. Deng, R., F. Zhao, and X. Zhong, T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians. Inflamm Res, 2017. 66(5): p. 413-424.
21. Howard, T.D., et al., Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. Journal of Allergy and Clinical Immunology, 2003. 112(4): p. 717-722.
22. Vergara, C.I., et al., A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia. International archives of allergy and immunology, 2010. 152(1): p. 32-40.
23. Jongepier, H., et al., Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy, 2004. 34(5): p. 757-60.
24. van Diemen, C.C., et al., A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. Am J Respir Crit Care Med, 2005. 172(3): p. 329-33.
| Files | ||
| Issue | Vol 57, No 11 (2019) | |
| Section | Articles | |
| DOI | https://doi.org/10.18502/acta.v57i11.3259 | |
| Keywords | ||
| Asthma ADAM33 rs2280091 Polymorphisms | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Ghaemi MR, Hemmati S, Rezaei A, Sadr M, Mohebbi B, Ghaffaripour H, Rezaei N, Mahdaviani SA. Association of ADAM33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran. Acta Med Iran. 2020;57(11):635-639.
