The Association Between Serum Levels of Leptin and Lipid Profiles in Cardiovascular Patients With Valve Calcification

  • Ramin Lotfi ORCID Lung and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Mohsen Molaie Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Ehsan Mohammadi Noori Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Khalil Soleimani Student Research Committee, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Amir Kiani Mail Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
: Leptin, Cardiovascular, Adipokines, Valve calcification, Lipid profiles


Adipose tissue-derived hormones known as adipokines, like leptin, have multiple bioactions. Notwithstanding the key roles of leptin in regulating energy homeostasis and metabolism, its cardiovascular functions are complex and not fully understood. This study aimed to investigate the association between serum concentrations of leptin and lipid profiles in patients with valve calcification. Seventy-two patients with valve calcification and 72 healthy individuals participated in this case-control study. The serum levels of biochemical markers and leptin were measured by the standard enzymatic methods and enzyme-linked immunosorbent assay (ELISA) technique, respectively. Significantly increased serum concentrations of FBS (P=0.001), urea (P<0.0001), creatinine (P=0.018), P (P<0.0001), LDL-C (P=0.011) and lower Ca (P=0.006), and HDL-C (P<0.0001) levels were observed in patients compared to controls. There was no significant difference in the serum level of TG and TC of patients than controls. Systolic and diastolic blood pressures were significantly increased in patients relative to controls (P<0.0001). However, a significantly diminished serum level of leptin was observed in patients than controls (P<0.0001). The correlation analysis demonstrated that the serum leptin concentration is negatively correlated with creatinine, but it is positively correlated with systolic blood pressure (P=0.0302, P=0.0362, respectively). There was no statistically significant association between serum levels of leptin and lipid profiles. Our findings indicated dyslipidemia and reduced serum leptin concentrations in patients with valve calcification, suggesting the role of lipid abnormalities and reduced leptin levels in the development and pathogenesis of valve calcification diseases.


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How to Cite
Lotfi R, Molaie M, Mohammadi Noori E, Soleimani K, Kiani A. The Association Between Serum Levels of Leptin and Lipid Profiles in Cardiovascular Patients With Valve Calcification. Acta Med Iran. 58(4):144-149.