Preparation of Novel Arabic Gum-C6H9NO Biopolymer as a Bedsore for Wound Care Application


The subcutaneous or hypodermic tissue is the innermost layer of the skin, which is essential for adipose tissue. The dermal attachment to the epidermis is a basal layer composed of collagen. This basal layer performs four different functions and acts as a scaffold for soft tissue organization. It is citing for regeneration that has selective permeability for serum filtration. Also, it is a barrier between different cell types, and cite where the epithelium subcutaneous to the cells. Untreated, bedsores can lead to serious complications, one of which is cellulite, a potentially life-threatening bacterial infection. As the bedsore wound spreads to the joints and bones, it may cause bone and joint infections that can damage the cartilage, tissue, and reduce joint function. The bacteria can then enter the bloodstream through wounds, leading to shock and life-threatening conditions. Stage II wounds can heal in one to six weeks, but wounds that lead to stage three or four may last several months or may never heal, especially in children with health problems. The purpose of this study was to design bio-based wounds with gelatin, Gum Arabic, and polyurethane. The wounds were made with different bio composite specimens. The procedure is gelatin, and gum Arabic was combined with certain percentages. The temperature of mixing and solubilization was set at 50°C. After complete fabrication of the material and complete dissolution of the samples in the solvent without any agglomeration, the samples were placed in a low-temperature freezer at -70°C and were placed in a freeze dryer. After the drying process is completed and the pores are ready on the wound heal sample, in the next stages, several tests are carried out to check the suitability of the produced wounds. The SEM analysis was performed on bio-based wounds in which the results showed the suitability and porosity of these wound dress were suitable. The presence of proper porosity and moisture level for wound healing and non-acidity, as well as the use of bed wound healing, have been distinguished from other conventional wound healing products in the market and research domain.

1) Zamierowski, D. S. (1990). U.S. Patent No. 4,969,880. Washington, DC: U.S. Patent and Trademark Office.
2) Webster, D. F. (1987). U.S. Patent No. 4,664,662. Washington, DC: U.S. Patent and Trademark Office.
3) Bellando-Randone, S., Pucci, T., Rasero, L., Denton, C. P., & Matucci-Cerinic, M. (2019). Wound Dressing for Digital Ulcers in Systemic Sclerosis. In Atlas of Ulcers in Systemic Sclerosis (pp. 161-164). Springer, Cham.
4) Batool, S., Hussain, Z., Niazi, M. B. K., Liaqat, U., & Afzal, M. (2019). Biogenic synthesis of silver nanoparticles and evaluation of physical and antimicrobial properties of Ag/PVA/starch nanocomposites hydrogel membranes for wound dressing application. Journal of Drug Delivery Science and Technology, 52, 403-414.
5) Doillon, C. J., & Silver, F. H. (1986). Collagen-based wound dressing: Effects of hyaluronic acid and firponectin on wound healing. Biomaterials, 7(1), 3-8.
6) Pushparaj, M., Ranganathan, R., & Ganesan, S. (2019). Design and Development of Drug Delivery System for Chronic Wound Using Additive Manufacturing. In 3D Printing and Additive Manufacturing Technologies (pp. 119-126). Springer, Singapore.
7) Dang, L. H., Huynh, N. T., Pham, N. O., Nguyen, C. T., Vu, M. T., & Tran, N. Q. (2019). Injectable nanocurcumin-dispersed gelatin–pluronic nanocomposite hydrogel platform for burn wound treatment. Bulletin of Materials Science, 42(2), 71.
8) Brkich, L. L., Nedorubov, A. A., Pyatigorskaya, N. V., Brkich, G. E., & Odintsova, E. S. (2019). The Study of the Wound Healing Activity of the Gel with a Comprehensive Therapeutic Effect. Open access Macedonian journal of medical sciences, 7(6), 908.
9) Pawar, V., Dhanka, M., & Srivastava, R. (2019). Cefuroxime conjugated chitosan hydrogel for treatment of wound infections. Colloids and Surfaces B: Biointerfaces, 173, 776-787.
10) Sahu, D. S., Upadhyaya, S. N., Bora, M., Puia, L., Chowdhary, S., & Rao, M. M. (2019). ACUTE DERMAL TOXICITY AND WOUND HEALING ACTIVITY OF MIKANIA MICRANTHA OINTMENT IN RATS. Indian Journal of Applied Research, 9(1).
11) Smaropoulos, E., & Cremers, N. A. (2019). The pro-healing effects of medical grade honey supported by a pediatric case series. Complementary Therapies in Medicine, 45, 14-18.
12) Rezvani Ghomi, E., Khalili, S., Nouri Khorasani, S., Esmaeely Neisiany, R., & Ramakrishna, S. (2019). Wound dressings: Current advances and future directions. Journal of Applied Polymer Science, 136(27), 47738.
13) Dadashzadeh, A., Imani, R., Moghassemi, S., Omidfar, K., & Abolfathi, N. (2019). Study of hybrid alginate/gelatin hydrogel-incorporated niosomal Aloe vera capable of sustained release of Aloe vera as potential skin wound dressing. Polymer Bulletin, 1-17.
14) Brunner & Suddarths.Text book of medical surgical nursing 2018.;Edition ,Lippott Williams &Wilkins,Philadelphia.
15) Tummalapalli, M., Berthet, M., Verrier, B., Deopura, B. L., Alam, M. S., & Gupta, B. (2016). Composite wound dressings of pectin and gelatin with aloe vera and curcumin as bioactive agents. International journal of biological macromolecules, 82, 104-113.
16) Davis, R. H., & Maro, N. P. (1989). Aloe vera and gibberellin. Anti-inflammatory activity in diabetes. Journal of the American Podiatric Medical Association, 79(1), 24-26.
17) Garcia-Orue, I., Gainza, G., Gutierrez, F. B., Aguirre, J. J., Evora, C., Pedraz, J. L., ... & Igartua, M. (2017). Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. International journal of pharmaceutics, 523(2), 556-566.
18) Choi, S. W., Son, B. W., Son, Y. S., Park, Y. I., Lee, S. K., & Chung, M. H. (2001). The wound‐healing effect of a glycoprotein fraction isolated from aloe vera. British Journal of Dermatology, 145(4), 535-545.
19) Fulton Jr, J. E. (1990). The stimulation of postdermabrasion wound healing with stabilized aloe vera gel‐polyethylene oxide dressing. The Journal of dermatologic surgery and oncology, 16(5), 460-467.
20) DAVIS, R. H., KABBANI, J. M., & MARO, N. P. (1986, January). Aloe vera and inflammation. In Proceedings of the Pennsylvania Academy of Science (pp. 67-70). Pennsylvania Academy of Science.
21) Curto, E. M., Labelle, A., & Chandler, H. L. (2014). Aloe vera: an in vitro study of effects on corneal wound closure and collagenase activity. Veterinary ophthalmology, 17(6), 403-410.
22) Davis, R. H. (1993). Biological activity of Aloe vera. Sofw Journal, 119, 646-646.
23) Ghannam, N., Kingston, M., Al-Meshaal, I. A., Tariq, M., Parman, N. S., & Woodhouse, N. (1986). The antidiabetic activity of aloes: preliminary clinical and experimental observations. Horm Res, 24(4), 288-294.
24) Milberg, I. L., & Tolmach, J. A. (1954). TREATMENT OF CHRONIC LEG ULCERS WITH ABSORBABLE GELATIN SPONGE (GELFOAM) POWDER: REPORT OF ONE HUNDRED SIX CASES. Journal of the American Medical Association, 155(14), 1219-1221.
25) Rafieian, S., Mahdavi, H., & Masoumi, M. E. (2019). Improved mechanical, physical and biological properties of chitosan films using Aloe vera and electrospun PVA nanofibers for wound dressing applications. Journal of Industrial Textiles, 1528083719866932.
26) Kumar, R., Singh, A. K., Gupta, A., Bishayee, A., & Pandey, A. K. (2019). Therapeutic potential of Aloe vera-A miracle gift of nature. Phytomedicine, 152996.
27) Bacakova, L., Zikmundova, M., Pajorova, J., Broz, A., Filova, E., Blanquer, A., ... & Kostakova, E. K. (2019). Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers. In Applications of Nanobiotechnology. IntechOpen.
28) Lin, C. W., Chen, Y. K., Tang, K. C., Yang, K. C., Cheng, N. C., & Yu, J. (2019). Keratin scaffolds with human adipose stem cells: Physical and biological effects toward wound healing. Journal of tissue engineering and regenerative medicine.
29) Oliveira, R. N., & McGuinness, G. B. (2019). Blended Gels of Sodium Carboxymethyl Cellulose Incorporating Antimicrobials for Absorbance and Wound Healing Applications. Cellulose-Based Superabsorbent Hydrogels, 1149-1176.
30) Ha, S. (2019). U.S. Patent Application No. 16/095,106.
31) Sikka, M. P., & Midha, V. K. (2019). The role of biopolymers and biodegradable polymeric dressings in managing chronic wounds. In Advanced Textiles for Wound Care (pp. 463-488). Woodhead Publishing.
32) Sharifimehr, S., Soltanizadeh, N., & Hossein Goli, S. A. (2019). Effects of edible coating containing nano‐emulsion of Aloe vera and eugenol on the physicochemical properties of shrimp during cold storage. Journal of the Science of Food and Agriculture, 99(7), 3604-3615.
33) Fiedler, J. O., Carmona, Ó. G., Carmona, C. G., José Lis, M., Plath, A. M. S., Samulewski, R. B., & Bezerra, F. M. (2019). Application of Aloe vera microcapsules in cotton nonwovens to obtain biofunctional textiles. The Journal of The Textile Institute, 1-7.
34) Muthulakshmi, M., & Subha, T. S. Physical, Thermal And Mechanical Characterization Of Aloe-Almond Hybrid Biopolymer Film.
35) Rad, Z. P., Mokhtari, J., & Abbasi, M. (2019). Calendula officinalis extract/PCL/Zein/Gum arabic nanofibrous bio-composite scaffolds via suspension, two-nozzle and multilayer electrospinning for skin tissue engineering. International journal of biological macromolecules.
36) Ramazan, E. (2019). Advances in fabric structures for wound care. In Advanced Textiles for Wound Care (pp. 509-540). Woodhead Publishing.
37) Arabloo, J., Grey, S., Mobinizadeh, M., Olyaeemanesh, A., Hamouzadeh, P., & Khamisabadi, K. (2016). Safety, effectiveness and economic aspects of maggot debridement therapy for wound healing. Medical journal of the Islamic Republic of Iran, 30, 319.
38) Eftekharizadeh, F., Dehnavieh, R., Hekmat, S. N., & Mehrolhassani, M. H. (2016). Health technology assessment on super oxidized water for treatment of chronic wounds. Medical journal of the Islamic Republic of Iran, 30, 384.
39) Khosravi Samani, M., Poorsattar Bejeh Mir, A., Mohammadnejad, G., Sajadi, B., & Fereshtehnejad, S. M. (2011). The potential of honey to promote wound healing in periodontology: a pilot randomized clinical trial. Medical Journal of The Islamic Republic of Iran (MJIRI), 25(4), 177-185. 
IssueVol 58, No 10 (2020) QRcode
Wound Bed sore Hospital infectious Freeze drying Soft tissue engineering

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How to Cite
Doozandeh Z, Saber-Samandari S, Khandan A. Preparation of Novel Arabic Gum-C6H9NO Biopolymer as a Bedsore for Wound Care Application. Acta Med Iran. 2020;58(10):520-530.