Original Article

Significant Post-Chemotherapy Decrease of Ovarian Reserve in Iranian Women With Breast Cancer

Abstract

Fertility preservation counseling has a high priority in young breast cancer (BC) patients. Cytotoxic chemicals used for chemotherapy in these patients increased the risk of premature ovarian failure. This study evaluated the anti-mullerian hormone (AMH) level at the time of diagnosis and within a month after the end of chemotherapy, while predicting the time of the return of ovarian function in BC cases (n=46) younger than 46 years for the first time in Iran. Cases were selected from those attending the breast oncology clinic of the two hospitals with a newly diagnosed in situ or invasive BC. The present study results showed AMH levels were significantly decreased in almost all women within a month after chemotherapy. It seems that the need for fertility preservation depends on patient age and baseline AMH level, but counseling should be offered by the clinician in young breast cancer patients.

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IssueVol 58, No 8 (2020) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/acta.v58i8.4591
Keywords
Breast cancer Anti-mullerian hormone Ovarian reserve Chemotherapy
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Eslami B, Jalaeefar A, Moini A, Omranipour R, Haghighi M, Alipour S. Significant Post-Chemotherapy Decrease of Ovarian Reserve in Iranian Women With Breast Cancer. Acta Med Iran. 2020;58(8):400-403.