Evaluation of Platelet Parameters in Patients With Coronary Artery Disease

  • Mahdieh Mehrpouri ORCID Mail Department of Laboratory Sciences, School of Allied Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran
  • Afshin Ahmad pour ORCID Department of Cardiology, School of Medicine, Taleghani General Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Esmail Shahabi Satlsar ORCID Department of Laboratory Sciences, School of Allied Medical Sciences, Guilan University of Medical Sciences, Langroud, Iran
Platelet count, Mean platelet volume (MPV), Platelet distribution width (PDW), Coronary artery disease (CAD), Acute coronary syndrome, Stable angina


Coronary artery disease (CAD) is one of the leading causes of death worldwide; therefore, identifying new risk factors to predict the severity of the disease is thought to be associated with mortality reduction. In an effort to investigate whether platelet parameters are related to the extent of CAD and can be considered as risk factors, we designed experiments to evaluate platelet parameters in these patients. In a cross‐sectional study, sixty-nine patients with CAD (including fifty-two patients with acute coronary syndrome and seventeen patients with stable angina) and sixty-four healthy volunteers were evaluated for platelet count, mean platelet volume (MPV), and platelet distribution width (PDW). Echocardiography, electrocardiogram (ECG), and coronary angiography were conducted as well. Results showed significantly higher values for MPV and PDW in patients with acute coronary syndrome as compared to patients with stable angina and healthy volunteers (P<0.001 and P=0.009, respectively). There was no significant difference in platelet count between patients and healthy volunteers (P=0.379). Our results also revealed a significant difference in the ejection fraction (EF) percentage between the three groups (P=0.008). Investigating the correlation between platelet parameters and EF percentage, ECG changes, and the results of coronary angiography did not show any significant association. The present study showed that the elevated levels of MPV and PDW in patients with CAD are not related to the extent of coronary artery disease, which was estimated by echocardiography, ECG changes, and coronary angiography. Thus, these parameters cannot be considered as risk factors for coronary artery disease.


1. Tavil Y, Sen N, Yazici H, Turfan M, Hizal F, Çengel A, et al. Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients. Platelets 2010;21(5):368-72.
2. Abbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ. Stromal cell–derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 2004;110(21):3300-5.
3. Yusuf S, Hawken S, Ôunpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The lancet 2004;364(9438):937-52.
4. Morrow DA. Cardiovascular risk prediction in patients with stable and unstable coronary heart disease. Circulation 2010;121(24):2681-91.
5. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clinical and Applied Thrombosis/Hemostasis 2003;9(3):177-90.
6. Steinhubl SR, Moliterno DJ. The role of the platelet in the pathogenesis of atherothrombosis. American Journal of Cardiovascular Drugs 2005;5(6):399-408.
7. Tendera M, Wojakowski W. Role of antiplatelet drugs in the prevention of cardiovascular events. Thrombosis research 2003;110(5-6):355-9.
8. Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochemia medica: Biochemia medica 2016;26(2):178-93.
9. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14(1):28.
10. Endler G, Klimesch A, Sunder‐Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. British journal of haematology 2002;117(2):399-404.
11. Cannon CP, Battler A, Brindis RG, Cox JL, Ellis SG, Every NR, et al. American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes: a report of the American College of Cardiology Task Force on clinical data standards (acute coronary syndromes writing committee) endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, American College of Emergency Physicians, American Heart Association, Cardiac Society of Australia & New Zealand, National Heart Foundation of Australia, Society for Cardiac Angiography and Interventions, and the Taiwan Society of Cardiology. Journal of the American College of Cardiology 2001;38(7):2114-30.
12. Alvitigala BY, Azra MAF, Kottahachchi DU, Jayasekera MMPT, Wijesinghe RANK. A study of association between platelet volume indices and ST elevation myocardial infarction. IJC heart & vasculature 2018;21:7-10.
13. Willoughby S, Holmes A, Loscalzo J. Platelets and cardiovascular disease. European Journal of Cardiovascular Nursing 2002;1(4):273-88.
14. Kamath S, Blann A, Lip G. Platelet activation: assessment and quantification. European heart journal 2001;22(17):1561-71.
15. Costa SC, de Matos Vinagre CG, Chacra APM, de Azevedo MRA. Platelet indices in patients with acute coronary syndrome. Journal of Biosciences and Medicines 2015;3(11):71.
16. Lippi G, Filippozzi L, Salvagno GL, Montagnana M, Franchini M, Guidi GC, et al. Increased mean platelet volume in patients with acute coronary syndromes. Archives of pathology & laboratory medicine 2009;133(9):1441-3.
17. Rodrigues B, França HH, Maiello JR, Romanini S, Pasuld F, Nunes E, et al. Mean Platelet Volume (MPV) Analysis In Patients with Coronary Arterial Disease. Am Soc Hematology; 2010.
18. De Luca G, Venegoni L, Iorio S, Secco GG, Cassetti E, Verdoia M, et al. Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets 2010;21(7):508-14.
19. Majumder B, Jain H, Chatterjee S, Das TK. Study of platelet count and platelet volume indices in the spectrum of coronary artery diseases and its clinicopathological correlation. Nigerian Journal of Cardiology 2018;15(1):63.
20. Aydogan A, Akkucuk S, Arica S, Motor S, Karakus A, Ozkan OV, et al. The analysis of mean platelet volume and platelet distribution width levels in appendicitis. Indian Journal of Surgery 2015;77(2):495-500.
21. Dalal J, Penny W, Saunders K, Sheridan D, Bloom A, Henderson A. Platelet counts and aggregates in coronary artery disease. European heart journal1982;3(2):107-13.
22. Ranjith M, Divya R, Mehta V, Krishnan M, KamalRaj R, Kavishwar A. Significance of platelet volume indices and platelet count in ischaemic heart disease. Journal of clinical pathology 2009;62(9):830-3.
23. De Luca G, Santagostino M, Secco GG, Cassetti E, Giuliani L, Franchi E, et al. Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Atherosclerosis 2009;206(1):292-7.
24. Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004;15(8):475-8.
25. Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. International journal of clinical practice 2005;59:981-982.
26. ŞENARAN H, Ileri M, AltinbaŞ A, KoŞar A, Yetkin E, ÖZTÜRK M, Karaaslan Y, Kirazli. Thrombopoietin and mean platelet volume in coronary artery disease. Clinical cardiology 2001;24:405-408.
How to Cite
Mehrpouri M, Ahmad pour A, Shahabi Satlsar E. Evaluation of Platelet Parameters in Patients With Coronary Artery Disease. Acta Med Iran. 58(9):419-423.