Acinar Cystic Transformation of the Pancreas: A Diagnostic Problem

  • Mehmet Yildirim ORCID Mail Department of General Surgery, Izmir Bozyaka Education and Research Hospital, University of Health Sciences, Izmir, Turkey
  • Asuman Argon ORCID Department of Pathology, Izmir Bozyaka Education and Research Hospital, University of Health Sciences, Izmir, Turkey
  • Sedat Tan ORCID Department of General Surgery, Izmir Bozyaka Education and Research Hospital, University of Health Sciences, Izmir,Turkey.
  • Ahmet Cekic ORCID Department of General Surgery, Izmir Bozyaka Education and Research Hospital, University of Health Sciences, Izmir, Turkey
Keywords:
Acinar cystic transformation, Pancreas, Cystic tumors

Abstract

Acinar cystic transformation (ACT) or acinar cell cystadenoma is a rare benign tumor of the pancreas. Their clinical presentation is nonspecific, thus hampering their detection and frequently leading to misdiagnosis. In this report, we present a case of ACT of the pancreas in a 54-year-old man that was vague abdominal symptoms. A magnetic resonance imaging was shown a well-defined cystic mass located in the head of the pancreas, measuring 57×47×23 mm. Our patient was treated by pancreaticoduodenectomy. In the macroscopic examination of the mass, a multicystic lesion was found in cream-colored pancreatic tissue. Histological and immunohistochemical studies examination revealed a cystic mass containing multiple cysts at varying sizes, lined by epithelial cells without atypia and positive staining of CK7, CK8/18, and CK19. A high index of clinical suspicion is required to diagnose this tumor. The surgical approach is to ensure accurate diagnosis and to avoid complications.

References

1.Albores-Saavedra J. Acinar cystadenoma of the pancreas: a previously undescribed tumor. Ann Diagn Pathol 2002; 6(2):113-5.
2.Singhi AD, Norwood S, Liu TC, Sharma R, Wolfgang CL, Schulick RD et al. Acinar cell cystadenoma of the pancreas: a benign neoplasm or non-neoplastic ballooning of acinar and ductal epithelium? Am J Surg Pathol 2013; 37(9):1329-35.
3. Khor TS, Badizadegan K, Ferrone C, Fernández-del Castillo C, Desai GS, Saenz A, et al. Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodules. Am J Surg Pathol 2012; 36(11):1579-91.
4. Zamboni G, Terris B, Scarpa A, Kosmahl M, Capelli P, Klimstra DS Acinar cell cystadenoma of the pancreas: a new entity? Am J Surg Pathol 2002;26(6):698-704.
5. Chaudhari B, Gandhi M , Shah CK. Acinar cell cystadenoma of pancreas: A case report and review of literature. Indian J Pathol Oncol 2020;7(1):191–.3.
Published
2020-11-10
How to Cite
1.
Yildirim M, Argon A, Tan S, Cekic A. Acinar Cystic Transformation of the Pancreas: A Diagnostic Problem. Acta Med Iran. 58(8):416-418.
QRcode
Section
Case Report(s)