Articles

The Effect of the Door to Needle Time of Streptokinase Administration on the Left Ventricular Function and Thrombolysis in Myocardial Infarction (TIMI) Flow Grade in Patients With Anterior Myocardial Infarction:A Single-Center, Prospective Follow-up Study

Abstract

Early administration of thrombolytic agents is the standard treatment and crucial for the outcome for patients presenting with acute myocardial infarction (MI). This study was conducted to evaluate the door to needle time of streptokinase administration and the left ventricular function in patients with anterior MI. This study was a prospective, single-center study on participants with anterior MI who were received streptokinase and non-streptokinase groups. After administration of streptokinase, QTc was measured in hyper-acute, acute, and recent phases of anterior MI in the case group and compared with acute and recent phases in the control group. The left ventricular function in 5 and 42 days after emergency department arrival was measured and compared in two groups. The data were analyzed by descriptive statistics method and variance analysis in the SPSS software, version 22. The level of significance was considered to be 0.05. Among 87 participants (45 streptokinases, 42 non-streptokinase), there was a significant relationship between the door to needle time in patients who received streptokinase in 1 hour (P=0.000), 3 hours (P=0.007), and 6 hours (P=0.016) after onset the chest pain and an ejection fraction of the patients in 5 days after hospitalization. Also, there was a significant relationship between ejection fraction in 5 days (P=0.000) and 42 days (P=0.000) of administration streptokinase and door to needle time. Reduction of the door to needle time after anterior MI has significant effects on QTc and incidence of threatening arrhythmia.

1. Younessi Heravi MA, Mojdekanlu M, Seyed Sharifi SH, Yaghubi M. The role of cardiovascular risk factors in the involvement of coronary arteries; A predictive model in the angiographic study. J North Khorasan Univ Med Sci 2014;6:199-205.
2. Younessi Heravi MA, Yaghubi M, Joharinia S. Effect of change in patient’s bed angles on pain after coronary angiography according to vital signals. J Res Med Sci 2015;20:937-43.
3. Ghasemi R, Vojdanparast M, Hosseinzadeh Maleki M, Yaghubi M. The Effect of the Door to Needle Time of Streptokinase Administration on the QTc Interval and the Incidence of Life-Threatening Arrhythmia in Patients With Anterior Myocardial Infarction. Acta Med Iran 2022;60:144-9.
4. Eshraghi A, Rezaei S, Yaghubi M. Risk Factors of Increased Corrected TIMI Frame Count in Angioplasty of Culprit Lesion after non-ST Elevation Acute Coronary Syndrome. Arch Pharm Pract 2020;11:141-8.
5. Abba AA, Wani BA, Rahmatullah RA, Khalil MZ, Kumo AM, Ghonaim MA. The door to needle time in administering thrombolytic therapy for acute myocardial infarction. Saudi Med J 2003;24:361-4.
6. Van der Vleuten PA, Rasoul S, Huurnink W, van der Horst IC, Slart RH, Reiffers S, et al. The importance of left ventricular function for long-term outcome after primary percutaneous coronary intervention. BMC Cardiovasc Disord 2008;8:4.
7. Shiga T, Hagiwara N, Ogawa H, Takagi A, Nagashima M, Yamauchi T, et al. Sudden cardiac death and left ventricular ejection fraction during long-term follow-up after acute myocardial infarction in the primary percutaneous coronary intervention era: results from the HIJAMI-II registry. Heart 2009;95:216-20.
8. Boersma E, Maas AC, Deckers JW, Simoons ML. Early thrombolytic treatment in acute myocardial infarction: Reappraisal of the golden hour. Lancet 1996;9030:771-5.
9. Abbasi Tashnizi M, Soltani G, Moeinipour AA, Ayatollahi H, Tanha AS, Jarahi L, et al. Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of IL-6 and IL-10. Iran Red Crescent Med J 2013;15:147-51.
10. Thiele H, Engelmann L, Elsner K, Kappl MJ, Storch WH, Rahimi K, et al. Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction. Eur Heart J 2005;26:1956-63.
11. Mistry N, Bøhmer E, Hoffmann P, Müller C, Bjørnerheim R, Kjeldsen SE, et al. Left ventricular function in acute myocardial infarction treated with thrombolysis followed by early versus late invasive strategy. Am Heart J 2010;160:73-9.
12. Beiraghdar M, Pourmoghaddas Z, Reza Torknezhad M, Torkan A. Ejection fraction and mortality rate of patients with isolated acute inferior myocardial infarction reperfused by streptokinase. ARYA Atheroscler 2011;7:54-57.
13. McNamara RL, Herrin J, Wang Y, Curtis JP, Bradley EH, Magid DJ, et al. Impact of Delay in Door-to-Needle Time on Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Am J Cardiol 2007;100:1227-32.
14. McNamara RL, Wang Y, Herrin J. Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am CollCardiol 2006;47:2180-6.
15. Peterson ED, Shah BR, Parsons L. Trends in quality of care for patients with acute myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006. Am Heart J 2008;156:1045-55.
16. O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK. ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: a Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, J Am Coll Cardiol 2013;61:e78-e140.
17. Newby LK, Rutsch WR, Califf RM, Simoons ML, Aylward PE, Armstrong PW, et al. Time from symptom onset to treatment and outcomes after thrombolytic therapy. GUSTO-1 Investigators. J Am Coll Cardiol 1996;27:1646-55.
18. Bax M, de Winter RJ, Schotborgh CE, Koch KT, Meuwissen M, Voskuil M, et al. Short- and long-term recovery of left ventricular function predicted at the time of primary percutaneous coronary intervention in anterior myocardial infarction. J Am Coll Cardiol 2004;43:534-41.
19. Sheiban I, Fragasso G, Rosano GM, Dharmadhikari A, Tzifos V, Pagnotta P, et al. Time course and determinants of left ventricular function recovery after primary angioplasty in patients with acute myocardial infarction. J Am Coll Cardiol 2001;38:464-71.
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IssueVol 60, No 4 (2022) QRcode
SectionArticles
DOI https://doi.org/10.18502/acta.v60i4.9267
Keywords
Coronary Angiography Streptokinase Ventricular Ejection Fractions.
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How to Cite
1.
Ghasemi R, Imani Moghaddam S, Ramezani F, Yaghubi M. The Effect of the Door to Needle Time of Streptokinase Administration on the Left Ventricular Function and Thrombolysis in Myocardial Infarction (TIMI) Flow Grade in Patients With Anterior Myocardial Infarction:A Single-Center, Prospective Follow-up Study. Acta Med Iran. 2022;60(4):229-234.