Laryngeal Cancer in Iranian Women


Laryngeal cancer is the most common malignant neoplasm in respiratory tract after lung cancer. The incidence is very different and male to female ratio has been decreased in previous decades. Different characteristics of laryngeal cancer in men and women have been described based on previous studies, so we decided to study its characteristics in Iranian women. This study's design is cross-sectional retrospective from 2010 to 2019 in Amir-Alam Hospital, Tehran University of Medicine. All patients with laryngeal cancer admitted to this hospital, were included. Females` records were studied exclusively. Among 1456 patients included in this study, 1391 were male and 65 were female(M/F=21.4:1). The mean age of males was 60.6 years and for females was 56.6. From 65 females, 60 were Squamous cell carcinoma and 5 were Sarcoma. Findings of 60 female SCC patients: The main risk factors were cigarette smoking and opium abuse. The subsite of tumor was supraglottic in 40%, glottis in 31% and transglottic in 29%. Treatment options were surgical (55%) and non-surgical (45%). Survival rates for one, two and five years were 84.3%, 67.4% and 44% respectively. Two-year survival of surgically treated patients is significantly better than non-surgically treated patients (P=0.048). The mean age of females was less than males. Two-year survival rate was better in surgically treated patients. The five-year survival of female patients was 44% and there is an emerging need for survival studies of male patients for comparison.

1. Steuer CE, El‐Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin 2017;67:31-50.
2. Machii R, Saika K. Incidence rate for larynx cancer in Japanese in Japan and in the United States from the Cancer Incidence in Five Continents. Jpn J Clin Oncol 2017;47:471-2.
3. Armstrong WB, Vokes DE, Verma SP. Malignant Tumors of the Larynx. In: Flint PW, Haughey BH, Lund VJ, Niparko JK, Robbins KT, Thomas JR, et al, eds. Cummings Otolaryngology Head and Neck Surgrry. 6th ed. Canada: Saunders, ELSEVIER; 2015:1601-33.
4. American Society of Clinical Oncology (ASCO). Laryngeal and Hypopharyngeal Cancer: Statistics. (Accessed at January, 2022,
5. Gholizadeh N, Najafi S, Zadeh MK, Afzali S, Sheykhbahaei N. Trend in laryngeal cancer, mortality and survival rate in Iran. J Contemp Med Sci 2018;4:7-11.
6. Mafi N, Kadivar M, Hosseini N, Ahmadi S, Zare-Mirzaie A. Head and neck squamous cell carcinoma in Iranian patients and risk factors in young adults: a fifteen-year study. Asian Pac J Cancer Prev 2012;13:3373-8.
7. Mirzaei M, Hosseini SA, Ghoncheh M, Soheilipour F, Soltani S, Soheilipour F, et al. Epidemiology and trend of head and neck cancers in Iran. Glob J Health Sci 2016;8:189-93.
8. Rad M, Chamani G, Zarei M, Hashemipour M. Epidemiological aspects of head and neck cancers in a group of Iranian population. Eur J Dent 2019;10:50-6.
9. Hassanipour S, Delam H, Nikbakht HA, Abdzadeh E, Salehiniya H, Arab-Zozani M, et al. The incidence of laryngeal cancer in Iran: A systematic review and meta-analysis. Clin Epidemiol Glob Health 2019;7:457-63.
10. van Dijk BA, Karim‐Kos HE, Coebergh JW, Marres HA, de Vries E. Progress against laryngeal cancer in The Netherlands between 1989 and 2010. Int J Cancer 2014;134:674-81.
11. Markou K, Christoforidou A, Karasmanis I, Tsiropoulos G, Triaridis S, Constantinidis I, et al. Laryngeal cancer: epidemiological data from Νorthern Greece and review of the literature. Hippokratia 2013;17:313-8.
12. Gallus S, Bosetti C, Franceschi S, Levi F, Negri E, La Vecchia C. Laryngeal cancer in women: tobacco, alcohol, nutritional, and hormonal factors. Cancer Epidemiol Biomarkers Prev 2003;12:514-7.
13. Kamangar F, Shakeri R, Malekzadeh R, Islami F. Opium use: an emerging risk factor for cancer? Lancet Oncol 2014;15:e69-77.
14. Mousavi MR, Damghani MA, Haghdoust AA, Khamesipour A. Opium and risk of laryngeal cancer. Laryngoscope 2003;113:1939-43.
15. Bakhshaee M, Raziee HR, Afshari R, Amali A, Roopoosh M, Lotfizadeh A. Opium addiction and risk of laryngeal and esophageal carcinoma. Iran J Otorhinolaryngol 2017;29:19-22.
16. MacLennan R, Da Costa J, Day NE, Law CH, Ng YK, Shanmugaratnam K. Risk factors for lung cancer in Singapore Chinese, a population with high female incidence rates. Int J Cancer 1977;20:854-60.
17. Dabirmoghaddam P, Taheri AK, Ghazavi H, Ebrahimnejad S, Karimian Z. Does opium dependency affect the pattern of involvement in laryngeal cancer? Iran J Otorhinolaryngol 2016;28:425-9.
18. Latifi H, Mikaili P, Latifi K, Torbati H. Squamous cell carcinoma of larynx in northwestern Iran. European J Exp Biol 2012;2:242-6.
19. Grover S, Swisher-McClure S, Mitra N, Li J, Cohen RB, Ahn PH, Lukens JN, et al. Total laryngectomy versus larynx preservation for T4a larynx cancer: patterns of care and survival outcomes. Int J Radiat Oncol Biol Phys 2015;92:594-601.
20. Pan Y, Hong Y, Liang Z, Zhuang W. Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database. Eur Arch Otorhinolaryngol 2019;276:193-201.
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Larynx Neoplasm Survival Women

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Dabirmoghaddam P, Yousefi J, Karimi E, Aghazadeh K, Moteshaker Arani M. Laryngeal Cancer in Iranian Women. Acta Med Iran. 2023;61(1):7-11.