Case Report

Pure Non-Gestational Choriocarcinoma: A Case Report

Abstract

Choriocarcinoma usually occurs in the uterine body. Non-gestational choriocarcinoma is an extremely rare malignant tumor with a poor prognosis and is difficult to distinguish from gestational choriocarcinoma. In this case report, we describe a case of pure non-gestational choriocarcinoma. A 35-year-old woman was referred to our academic hospital with a pathology report of non-gestational choriocarcinoma of right ovarian cystectomy. Since the diagnosis did not coordinate with the patient's symptoms, PCR amplifying, and genomic DNA were performed. Finally, the diagnosis of pure non-gestational choriocarcinoma was confirmed. In follow-up, lung and brain metastasis was determined. Brain radiotherapy and BEP regimen chemotherapy were prescribed. However, the response was not appropriate, so she is currently undergoing palliative chemotherapy. Stage IV primary pure ovarian choriocarcinoma is a very aggressive tumor. Regardless of the nature of the tumor, the response to the treatment may not be good. Indeed the treatment of each case should be individualized.

1. Hirata Y, Yanaihara N, Yanagida S, Fukui K, Iwadate K, Kiyokawa T, et al. Molecular genetic analysis of nongestational choriocarcinoma in a postmenopausal woman: a case report and literature review. Int J Gynecol Pathol 2012;31:364-8.
2. Jiao LZ, Xiang Y, Feng FZ, Wan XR, Zhao J, Cui QC, et al. Clinical analysis of 21 cases of nongestational ovarian choriocarcinoma. Int J Gynecol Cancer 2010;20:299-302.
3. Kong B, Tian YJ, Zhu WW, Qin YJ. A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: Case report and literature review. J Obstet Gynaecol Res 2009;35:574-8.
4. Goswami D, Sharma K, Zutshi V, Tempe A, Nigam S. Nongestational pure ovarian choriocarcinoma with contralateral teratoma. Gynecol Oncol 2001;80:262-6.
5. Hu T, Yang M, Zhu H, Shi G, Wang H. Pure non‐gestational ovarian choriocarcinoma in a 45, XO/46, XX SRY‐negative true hermaphrodite. J Obstet Gynaecol Res 2011;37:1900-5.
6. Waseda Y, Komai Y, Yano A, Fujii Y, Noguchi N, Kihara K. Pathological complete response and two-year disease-free survival in a primary gastric choriocarcinoma patient with advanced liver metastases treated with germ cell tumor-based chemotherapy: a case report. Jpn J Clin Oncol 2012;42:1197-201.
7. Saito M, Azuma T, Nakamura K. On ectopic choriocarcinoma. World Obstet Gynecol 1963;17:459-84.
8. Liu Y, Yang J, Ren T, Zhao J, Feng F, Wan X, et al. The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases. J Reprod Med 2014;59:221-6.
9. Ramachandran BS, Murugesan M, Ali M, Padmanabhan P. Primary pancreatic choriocarcinoma presenting as pancreatitis. JOP 2012;13:217-8.
10. Fisher RA, Newlands ES, Jeffreys AJ, Boxer GM, Begent RH, Rustin GJ, et al. Gestational and nongestational trophoblastic tumors distinguished by DNA analysis. Cancer 1992;69:839-45.
11. Tsujioka H, Hamada H, Miyakawa T, Hachisuga T, Kawarabayashi T. A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis. Gynecol Oncol 2003;89:540-2.
12. Shigematsu T, Kamura T, Arima T, Wake N, Nakano H. DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report. Eur J Gynaecol Oncol 2000;21:153-4.
13. Motamedi E, Yousefi Z, Mottaghi M, Davachi B, Jafarian AH. Primary Pure Non-G1estational Ovarian Choriocarcinoma: A Case Report. Int J Cancer Manag 2017;10:e8116.
14. Mascilini F, Moro F, Di Grazia FM, Leombroni M, Distefano M, Fanfani F, et al. Clinical and ultrasound features of non-gestational ovarian choriocarcinoma. Ultrasound Obstet Gynecol 2017;52:121-3.
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IssueVol 61 No 7 (2023) QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/acta.v61i7.14501
Keywords
Choriocarcinoma Non-gestational choriocarcinoma Chemotherapy

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Azimi H, Jafarian AH, Davachi B, Zandieh E, Shirzadeh F, Yousefi Z. Pure Non-Gestational Choriocarcinoma: A Case Report. Acta Med Iran. 2023;61(7):439-442.