The Effect of Circuit Resistance Training With Varying Intensity on Selected Inflammatory Markers in Obese Men
,
Abstract
Obesity and associated chronic inflammation lead to insulin resistance. The aim of this study was to evaluate the effect of varying intensity circuit resistance training on metabolic and inflammatory markers in obese men. In a semi-experimental trial, 44 obese men were selected and randomly divided into four groups, including 1) Control (n=11), 2) Low-intensity circuit resistance training (n=11), 3) Moderate-intensity circuit resistance training (n=11), and 4) High-intensity circuit resistance training (n=11). Resistance training was performed at different intensities, including 1) High-intensity circuit resistance training (80% 1RM), 2) Moderate-intensity circuit resistance (60% 1RM), and 3) Low-intensity circuit resistance training (40% 1RM), three sessions per week for 12 weeks. Serum levels of Dectin-1, TLR2, TLR4, MyD88 were measured using an ELISA kit. Data were analyzed with covariance analysis at P<0.05. Twelve weeks of moderate and high-intensity circuit resistance training significantly reduced weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR (P=0.001). The reduction of weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR were significant in obese men in the high-intensity training group compared to low-intensity training (P=0.001). It seems that circuit resistance training, especially high-intensity circuit resistance training, can be used as an option to reduce the inflammatory and metabolic complications associated with obesity.
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7. Dasu MR, Devaraj S, Park S, Jialal I. Increased Toll-like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects. Diabetes Care 2010;33:861-8.
8. Castoldi A, Andrade-Oliveira V, Aguiar CF, Amano MT,Lee J, Miyagi MT, et al. Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88.Cell Rep 2017;19:2272-88.
9. Gantner BN, Simmons RM, Canavera SJ, Akira S,Underhill DM. Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2. J Exp Med 2003;197:1107-17.
10. Willment JA, Marshall AS, Reid DM, Williams DL, Wong SY, Gordon S, et al. The Human β‐Glucan Receptor is Widely Expressed and Functionally Equivalent to Murine Dectin‐1 on Primary Cells. Eur J Immunol 2005;35:1539-47.
11. Plantinga TS, Fransen J, Takahashi N, Stienstra R, van Riel PL, van den Berg WB, et al. Functional Consequences of
Dectin-1 Early Stop Codon Polymorphism Y238X in Rheumatoid Arthritis. Arthritis Res Ther 2010;12:R26.
12. Romero-Arenas S, Martínez-Pascual M, Alcaraz PE. Impact of Resistance Circuit Training on Neuromuscular,
Cardiorespiratory and Body Composition Adaptations in the Elderly. Aging Dis 2013;4:256-63.
13. Zanuso S, Bergamin M, Jimenez A, Pugliese G, D'Errico V, Nicolucci A, et al. Determination of Metabolic Equivalents During Low-and High-intensity Resistance Exercise in Healthy Young Subjects and Patients with Type 2 diabetes. Biol Sport 2016;33:77-84.
14. Reid DM, Montoya M, Taylor PR, Borrow P, Gordon S, Brown GD, et al. Expression of the β-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J Leukoc Biol 2004;76:86-94.
15. Baechle T, Earle R. Essentials of strength training and conditioning. Champaign: Human Kinetics; 2008.
16. Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, et al. IRF5 Promotes Inflammatory Macrophage Polarization and TH1-TH17 Responses. Nat Immunol 2011;12:231-8.
17. del Fresno C, Soulat D, Roth S, Blazek K, Udalova I, Sancho D, et al. Interferon-b Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells is Crucial for Immunity to C. albicans. Immunity 2013;38:1176-86.
18. Thiagarajan PS, Yakubenko VP, Elsori DH, Yadav SP, Willard B, Tan CD, et al. Vimentin is an Endogenous Ligand for the Pattern Recognition Receptor Dectin-1. Cardiovasc Res 2013;99:494-504.
19. Ruffino JS, Davies NA, Morris K, Ludgate M, Zhang L, Webb R, et al. Moderate-intensity Exercise Alters Markers
of Alternative Activation in Circulating Monocytes in Females: A Putative Role for PPARγ. Eur J Appl Physiol 2016;116:1671-82.
20. Zanchi NE, Lira FS, de Siqueira Filho MA, Rosa JC, de Oliveira Carvalho CR, Seelaender M, et al. Chronic Lowfrequency/Volume Resistance Training Reduces Proinflammatory Cytokine Protein Levels and TLR4 mRNA in Rat Skeletal Muscle. Eur J Appl Physiol 2010;109:1095-102.
21. Rosa JC, Lira FS, Eguchi R, Pimentel GD, Venancio DP,Cunha CA, et al. Exhaustive Exercise Increases Inflammatory Response via Toll-like Receptor-4 and NFkappaBp65 Pathway in Rat Adipose Tissue. J Cell Physiol 2011;226:1604-7.
22. Rodriguez-Miguelez P, Fernandez-Gonzalo R, Collado PS, Almar M, Martinez-Florez S, de Paz JA, et al. Whole-body
Vibration Improves the Anti-inflammatory Status in Elderly Subjects through Toll-like Receptor 2 and 4 Signaling Pathways. Mech Ageing Dev 2015;150:12-9.
23. Oliveira M, Gleeson M. The Influence of Prolonged Cycling on Monocyte Toll-like Receptor 2 and 4 Expression in Healthy Men. Eur J Appl Physiol 2010;10:251-9.
24. McFarlin BK, Flynn MG, Campbell WW, Craig BA, Robinson JP, Stewart LK, et al. Physical Activity Status Not Age Influences Inflammatory Biomarkers and Tolllike Receptor 4. J Gerontol A Biol Sci Med Sci 2006;61:388-93.
25. Kumar H, Kawai T, Akira S. Toll-like Receptors and Innate Immunity. Biochem Biophys Res Commun 2009;388:621-5.
26. Hu S, Zhe Y, Gomez-Pinilla F, Sally Ann Frautschy. Exercise Can Increase Small Heat Shock Proteins (sHSP) and Pre- and Post-synaptic Proteins in the Pippocampus.Brain Res 2009;1249:191-201.
27. Carpenter KC, Strohacker K, Breslin WL, Lowder TW, Agha NH, McFarlin BK. Effects of Exercise on Weight Loss and Monocytes in Obese Mice. Comp Med 2012;62:21-6.
28. Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance Training Reduces Subclinical Inflammation in Obese, Postmenopausal Women. Med SciSports Exerc 2012;44:2099-110.
29. Prestes J, da Cunha Nascimento D, Tibana RA, Teixeira TG, Vieira DC, Tajra V, et al. Understanding the Individual Responsiveness to Resistance Training Periodization. Age (Dordr) 2015;37:55.
30. Fernandez-Gonzalo R, De Paz JA, Rodriguez-Miguelez P, Cuevas MJ, Gonzalez-Gallego J. TLR4-mediated Blunting
of Inflammatory Responses to Eccentric Exercise in Young Women. Mediators Inflamm 2014;2014:479395.
31. Ma Y, He M, Qiang L. Exercise Therapy Downregulates the Overexpression of TLR4, TLR2, MyD88 and NF-κB
after Cerebral Ischemia in Rats. Int J Mol Sci 2013;14:3718-33.
32. Larsson E, Tremaroli V, Lee YS, Koren O, Nookaew I, Fricker A, et al. Analysis of Gut Microbial Regulation of
Host Gene Expression along the Length of the Gut and Regulation of Gut Microbial Ecology through MyD88. Gut
2012;61:1124-31.
33. Nikseresht M. Interleukin-6 and Insulin Resistance Response to Exercise Training and Detraining in Middleaged
and Obese Men: A Randomized Clinical Trial. J Shahrekord Univ Med Sci 2016;18:89-99.
34. Fathi R, Nazar Ali P, Adabi Z. The Effect of 8 Weeks of Resistance Training on Omentin Levels and Insulin Resistance Index in Obese and Overweight Women. J Appl Exerc Physiol 2014;10:104-13.
2. Hazley L, Ingle L, Tsakirides C, Carroll S, Nagi D. Impact of a Short-Term, Moderate Intensity, Lower Volume Circuit Resistance Training Programme on Metabolic Risk Factors in Overweight/Obese Type 2 Diabetics. Res Sports
Med 2010;18:251-62.
3. Kolahdouzi S, Baghadam M, Kani-Golzar FA, Saeidi A, Jabbour G, Ayadi A, et al. Progressive Circuit Resistance
Training Improves Inflammatory Biomarkers and Insulin Resistance in Obese Men. Physiol Behav 2019;205:15-21 .
4. Camargo MD, Stein R, Ribeiro JP, Schvartzman PR,Rizzatti MO, Schaan BD. Circuit Weight Training and
Cardiac Morphology: A Trial with Magnetic Resonance Imaging. Br J Sports Med 2008;42:141-5.
5. Jaacks LM, Vandevijvere S, Pan A, McGowan CJ, Wallace C, Imamura F, et al. The Obesity Transition: Stages of the
Global Epidemic. Lancet Diabetes Endocrinol 2019;7:231-40.
6. Cortez-Espinosa N, García-Hernández MH, Reynaga-Hernández E, Cortés-García JD, Corral-Fernández NE,Rodríguez-Rivera JG, et al. Abnormal Expression and Function of Dectin-1 Receptor in Type 2 Diabetes Mellitus Patients with Poor Glycemic Control (HbA1c> 8%).Metabolism 2012;61:1538-46.
7. Dasu MR, Devaraj S, Park S, Jialal I. Increased Toll-like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects. Diabetes Care 2010;33:861-8.
8. Castoldi A, Andrade-Oliveira V, Aguiar CF, Amano MT,Lee J, Miyagi MT, et al. Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88.Cell Rep 2017;19:2272-88.
9. Gantner BN, Simmons RM, Canavera SJ, Akira S,Underhill DM. Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2. J Exp Med 2003;197:1107-17.
10. Willment JA, Marshall AS, Reid DM, Williams DL, Wong SY, Gordon S, et al. The Human β‐Glucan Receptor is Widely Expressed and Functionally Equivalent to Murine Dectin‐1 on Primary Cells. Eur J Immunol 2005;35:1539-47.
11. Plantinga TS, Fransen J, Takahashi N, Stienstra R, van Riel PL, van den Berg WB, et al. Functional Consequences of
Dectin-1 Early Stop Codon Polymorphism Y238X in Rheumatoid Arthritis. Arthritis Res Ther 2010;12:R26.
12. Romero-Arenas S, Martínez-Pascual M, Alcaraz PE. Impact of Resistance Circuit Training on Neuromuscular,
Cardiorespiratory and Body Composition Adaptations in the Elderly. Aging Dis 2013;4:256-63.
13. Zanuso S, Bergamin M, Jimenez A, Pugliese G, D'Errico V, Nicolucci A, et al. Determination of Metabolic Equivalents During Low-and High-intensity Resistance Exercise in Healthy Young Subjects and Patients with Type 2 diabetes. Biol Sport 2016;33:77-84.
14. Reid DM, Montoya M, Taylor PR, Borrow P, Gordon S, Brown GD, et al. Expression of the β-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J Leukoc Biol 2004;76:86-94.
15. Baechle T, Earle R. Essentials of strength training and conditioning. Champaign: Human Kinetics; 2008.
16. Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, et al. IRF5 Promotes Inflammatory Macrophage Polarization and TH1-TH17 Responses. Nat Immunol 2011;12:231-8.
17. del Fresno C, Soulat D, Roth S, Blazek K, Udalova I, Sancho D, et al. Interferon-b Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells is Crucial for Immunity to C. albicans. Immunity 2013;38:1176-86.
18. Thiagarajan PS, Yakubenko VP, Elsori DH, Yadav SP, Willard B, Tan CD, et al. Vimentin is an Endogenous Ligand for the Pattern Recognition Receptor Dectin-1. Cardiovasc Res 2013;99:494-504.
19. Ruffino JS, Davies NA, Morris K, Ludgate M, Zhang L, Webb R, et al. Moderate-intensity Exercise Alters Markers
of Alternative Activation in Circulating Monocytes in Females: A Putative Role for PPARγ. Eur J Appl Physiol 2016;116:1671-82.
20. Zanchi NE, Lira FS, de Siqueira Filho MA, Rosa JC, de Oliveira Carvalho CR, Seelaender M, et al. Chronic Lowfrequency/Volume Resistance Training Reduces Proinflammatory Cytokine Protein Levels and TLR4 mRNA in Rat Skeletal Muscle. Eur J Appl Physiol 2010;109:1095-102.
21. Rosa JC, Lira FS, Eguchi R, Pimentel GD, Venancio DP,Cunha CA, et al. Exhaustive Exercise Increases Inflammatory Response via Toll-like Receptor-4 and NFkappaBp65 Pathway in Rat Adipose Tissue. J Cell Physiol 2011;226:1604-7.
22. Rodriguez-Miguelez P, Fernandez-Gonzalo R, Collado PS, Almar M, Martinez-Florez S, de Paz JA, et al. Whole-body
Vibration Improves the Anti-inflammatory Status in Elderly Subjects through Toll-like Receptor 2 and 4 Signaling Pathways. Mech Ageing Dev 2015;150:12-9.
23. Oliveira M, Gleeson M. The Influence of Prolonged Cycling on Monocyte Toll-like Receptor 2 and 4 Expression in Healthy Men. Eur J Appl Physiol 2010;10:251-9.
24. McFarlin BK, Flynn MG, Campbell WW, Craig BA, Robinson JP, Stewart LK, et al. Physical Activity Status Not Age Influences Inflammatory Biomarkers and Tolllike Receptor 4. J Gerontol A Biol Sci Med Sci 2006;61:388-93.
25. Kumar H, Kawai T, Akira S. Toll-like Receptors and Innate Immunity. Biochem Biophys Res Commun 2009;388:621-5.
26. Hu S, Zhe Y, Gomez-Pinilla F, Sally Ann Frautschy. Exercise Can Increase Small Heat Shock Proteins (sHSP) and Pre- and Post-synaptic Proteins in the Pippocampus.Brain Res 2009;1249:191-201.
27. Carpenter KC, Strohacker K, Breslin WL, Lowder TW, Agha NH, McFarlin BK. Effects of Exercise on Weight Loss and Monocytes in Obese Mice. Comp Med 2012;62:21-6.
28. Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance Training Reduces Subclinical Inflammation in Obese, Postmenopausal Women. Med SciSports Exerc 2012;44:2099-110.
29. Prestes J, da Cunha Nascimento D, Tibana RA, Teixeira TG, Vieira DC, Tajra V, et al. Understanding the Individual Responsiveness to Resistance Training Periodization. Age (Dordr) 2015;37:55.
30. Fernandez-Gonzalo R, De Paz JA, Rodriguez-Miguelez P, Cuevas MJ, Gonzalez-Gallego J. TLR4-mediated Blunting
of Inflammatory Responses to Eccentric Exercise in Young Women. Mediators Inflamm 2014;2014:479395.
31. Ma Y, He M, Qiang L. Exercise Therapy Downregulates the Overexpression of TLR4, TLR2, MyD88 and NF-κB
after Cerebral Ischemia in Rats. Int J Mol Sci 2013;14:3718-33.
32. Larsson E, Tremaroli V, Lee YS, Koren O, Nookaew I, Fricker A, et al. Analysis of Gut Microbial Regulation of
Host Gene Expression along the Length of the Gut and Regulation of Gut Microbial Ecology through MyD88. Gut
2012;61:1124-31.
33. Nikseresht M. Interleukin-6 and Insulin Resistance Response to Exercise Training and Detraining in Middleaged
and Obese Men: A Randomized Clinical Trial. J Shahrekord Univ Med Sci 2016;18:89-99.
34. Fathi R, Nazar Ali P, Adabi Z. The Effect of 8 Weeks of Resistance Training on Omentin Levels and Insulin Resistance Index in Obese and Overweight Women. J Appl Exerc Physiol 2014;10:104-13.
| Files | ||
| Issue | Vol 59, No 12 (2021) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/acta.v59i12.8067 | |
| Keywords | ||
| Circuit resistance training Chronic inflammation Insulin resistance Obesity | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Emamdost S, Abbassi Daloii A, Barari A, Saeidi A. The Effect of Circuit Resistance Training With Varying Intensity on Selected Inflammatory Markers in Obese Men. Acta Med Iran. 2021;59(12):733-739.
