Articles

Effect of Dry Eye Disease on Central Corneal Thickness and Corneal Topometric Indices Measured by Scheimpflug Tomography

Abstract

To evaluate the effect of dry eye disease (DED) on the central corneal thickness and anterior corneal surface irregularity parameters using Scheimpflug tomography. In this study, the central corneal thickness and topometric indices of the anterior corneal surface were compared between the right eyes of 43 subjects with dry eye (DE group) and the right eyes of 35 non-dry eye individuals (NDE group). The central corneal thickness (CCT) and the topometric indices of the anterior corneal surface, including IVA, IHA, ISV, and IHD, were measured using the Pentacam HR (Pentacam-HR, Oculus, Wetzlar, Germany). Dry eye was diagnosed using a symptom questionnaire, TBUT, and Schirmer’s test without anesthesia. The mean ISV, IVA, IHA, and IHD were 17.02 3.43, 0.114 0.04, 5.82 4.82, and 0.011 0.01 in the DE group and 14.65 3.10, 0.086 .03, 3.70 3.23, and 0.007 0.00 in the NDE group, respectively. All of the above corneal irregularity indices were significantly higher in the DE group (P<0.05). The mean CCT was 531.19 µ (±34.88 µ) and 540.66 µ (±27.13 µ) in the DE and NDE group, respectively. Based on linear regression analysis, ISV, IVA, IHA, and IHD had a significant association with DED (P<0.05), while CCT had no significant association with DED (P=0.148). DED significantly increases corneal surface irregularity, but it has no significant effects on CCT measured by the Pentacam.

1. Montés-Micó R, Cerviño A, Ferrer-Blasco T, García-Lázaro S, Madrid-Costa D. The tear film and the optical quality of the eye. Ocul Surf 2010;8:185-92.
2. Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, et al. TFOS DEWS II Definition and Classification Report. Ocul Surf 2017;15:276-83.
3. Pflugfelder SC. Tear fluid influence on the ocular surface. Adv Exp Med Biol 1998;438:611-7.
4. Miljanović B, Dana R, Sullivan DA, Schaumberg DA. Impact of dry eye syndrome on vision-related quality of life. Am J Ophthalmol 2007;143:409-15.
5. Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, et al. TFOS DEWS II Epidemiology Report. Ocul Surf 2017;15:334-65.
6. Liu Z, Pflugfelder SC. Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology 1999;106:939-43.
7. Ozkan Y, Bozkurt B, Gedik S, Irkeç M, Orhan M. Corneal topographical study of the effect of lacrimal punctum occlusion on corneal surface regularity in dry eye patients. Eur J Ophthalmol 2001;11:116-9.
8. de Paiva CS, Lindsey JL, Pflugfelder SC. Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology 2003;110:1102-9.
9. Pole JJ, Batzer JK. Central corneal thickness of patients with dry eyes. J Am Optom Assoc 1985;56:220-1.
10. Høvding G. The central corneal thickness in keratoconjunctivitis sicca. Acta Ophthalmol (Copenh) 1992;70:108-10.
11. Cingü AK, Cınar Y, Türkcü FM, Sahin M, Kaya S, Bozkurt M, et al. Evaluation of corneal parameters with scheimpflug imaging in patients with rheumatoid arthritis. Ocul Immunol Inflamm 2013;21:360-5.
12. Al-Mezaine HS, Al-Amro SA, Kangave D, Sadaawy A, Wehaib TA, Al-Obeidan S. Comparison between central corneal thickness measurements by oculus pentacam and ultrasonic pachymetry. Int Ophthalmol 2008;28:333-8.
13. Jain R, Grewal S. Pentacam: principle and clinical applications. J Curr Glaucoma Pract 2009;3:20-32.
14. Goto T, Klyce SD, Zheng X, Maeda N, Kuroda T, Ide C. Gender- and age-related differences in corneal topography. Cornea 2001;20:270-6.
15. Mishima S. Some Physiological Aspects of the Precorneal Tear Film. Arch Ophthalmol 1965;73:233-41.
16. Chen JJ, Rao K, Pflugfelder SC. Corneal epithelial opacity in dysfunctional tear syndrome. Am J Ophthalmol 2009;148:376-82.
17. Huang FC, Tseng SH, Shih MH, Chen FK. Effect of artificial tears on corneal surface regularity, contrast sensitivity, and glare disability in dry eyes. Ophthalmology 2002;109:1934-40.
18. Liu Z, Pflugfelder SC. Corneal thickness is reduced in dry eye. Cornea 1999;18:403-7.
19. Sanchis-Gimeno JA, Lleó-Pérez A, Alonso L, Rahhal MS, Martínez-Soriano F. Reduced corneal thickness values in postmenopausal women with dry eye. Cornea 2005;24:39-44.
20. Akyol-Salman I, Azizi S, Mumcu U, Öndaş O, Baykal O. Central corneal thickness in patients with meibomian gland dysfunction. Clin Exp Optom 2011;94:464-7.
21. Prydal JI, Artal P, Woon H, Campbell FW. Study of human precorneal tear film thickness and structure using laser interferometry. Invest Ophthalmol Vis Sci 1992;33:2006-11.
22. King-Smith PE, Fink BA, Hill RM, Koelling KW, Tiffany JM. The thickness of the tear film. Curr Eye Res 2004;29:357-68.
23. Kang NH, Park YG, Jun RM. Measurement of Precorneal Tear Film Using Scheimpflug Camera and Relationship with Parameters for Dry Eye. J Korean Ophthalmol Soc 2015;56:1699-705.
24. Dayanir V, Sakarya R, Ozcura F, Kir E, Aktunç T, Ozkan BS, et al. Effect of corneal drying on central corneal thickness. J Glaucoma 2004;13:6-8.
25. Gilbard JP, Farris RL, Santamaria J 2nd. Osmolarity of tear microvolumes in keratoconjunctivitis sicca. Arch Ophthalmol 1978;96:677-81.
26. Yeh S, Song XJ, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci 2003;44:124-9.
27. Villani E, Galimberti D, Viola F, Mapelli C, Ratiglia R. The cornea in Sjogren's syndrome: an in vivo confocal study. Invest Ophthalmol Vis Sci 2007;48:2017-22.
28. Nissen J, Hjortdal JO, Ehlers N, Frost-Larsen K, Sørensen T. A clinical comparison of optical and ultrasonic pachometry. Acta Ophthalmol (Copenh) 1991;69:659-63.
29. Cairns G, McGhee CN. Orbscan computerized topography: attributes, applications, and limitations. J Cataract Refract Surg 2005;31:205-20.
30. Han YS, Ahn JH, Lew HM. The effects of dry eye on the corneal thickness measured by orbscan and ultrasonic pachymetry. J Korean Ophthalmol Soc 2002;43:17-22.
31. Hirnschall N, Crnej A, Gangwani V, Findl O. Effect of fluorescein dye staining of the tear film on Scheimpflug measurements of central corneal thickness. Cornea 2012;31:18-20.
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IssueVol 60 No 12 (2022) QRcode
SectionArticles
DOI https://doi.org/10.18502/acta.v60i12.11831
Keywords
Dry eye Corneal topometric indices Pentacam Tomography Tear film
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1.
Siyahkamari M, Asharlous A, Mirzajani A, Koohian H, Jafarzadepour E, Ostadimoghaddam H, Babaei N, Yekta A, Khabazkhoob M. Effect of Dry Eye Disease on Central Corneal Thickness and Corneal Topometric Indices Measured by Scheimpflug Tomography. Acta Med Iran. 2023;60(12):777-781.