2023 CiteScore: 0.7
pISSN: 0044-6025
eISSN: 1735-9694
Editor-in-Chief:
Ahmadreza Dehpour, PharmD, PhD
This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE).
Vol 26, No 1-4 (1984)
Original Article(s)
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The i s c l ation o f Sporot hrix Schencki i in IRAN i s reported from the arm l esions of a housewi f e for the first time. The identity o f the fungus was based on its gross and microscopic cultural morphol ogy including demonstration of its dimorphic character.
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We conducted a retrospective study of 25 cases (15 boys and 12 girls) of Wilson's disease(Hepatolenticular degeneration)spanning a period of 8 years. Age at the time of diagnosis ranged between 3-17 years. The f ollowing clinical forms were observed:
Hepatic-13, neurologic-4, mixed (hepatic & neurologic)-S, --a s ympt oma t i c - 3 , Kayser-Fleischer corneal ring s were obs erved in 12 pat ients .
Diagnosis wa s confi rmed by l ow serum cer ulop lasmi n , low ser um c oppe r, Increased uri nar y copper and abno rmal aminoaciduria. Of different treatment s chedul e s (l ow copper di ets, D'. Penicillamine, metro"nidazole, K sulfide 1 T.E.T., 2Cl . and BAL) the diatary management plus D. Penicillamine was the most effective.Mortality was 8(32%)due to either fulminent hemorrhage or hepatic failure. -
The endotoxin dose response of recruited and activated tissue macrophages isolated from a rat model of liver injury has been measured after 24 hours in in vitro culture, with respect to their production of a lysosomal enzyme, N-acetyl-glucosaminidase (tlAG). There were no significant differences in the NAG activity in cell lysates or supernatants following a two-hour exposure of the macrophages to a range of endotoxin concentrations (50 ~g. 5 ng./rnl.); nor were any significant differences observed when compared to NAG activity of cells recruited but not exposed to endotoxin. The level of NAG activity in the supernatants and cell lysates of these recruited cells was significantly higher (p<:O.02) than the levels measured in resident macrophages (Kup7.fer cells)isolated from normal rat livers. We conclude that with respect to lysosomal enzyme release these cells have already been maximal.ly activated in vivo and that further hepatic daQage induced by endotoxin .:l.uministration occurs through mechanisms other than increased release of lysosomal enzymes.
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In an attempt to investigate the relationship of birth rank and family size with the incidence of neurosis in an Iranian culture, case notes of 1029 schizophrenic patients as (497 males and 532 females) referred to psychiatric clinic for insured workers were studied. The incidence of neurasis appeared to be significantly more frequent among the first-half position of birth rders in The families of 5 children and over; this bei-ng more marked-in males than in females; and the first second births comprising the lighest incidence of the illness.
