"Beneficial effects of vitamin C and vitamin E on blood pressure in Hyperandrogenic women "

  • Sotoudeh G
  • Siassi F
  • Mirdamadi SR
  • Mohammad K
  • Golestan B
  • Chamari M
Keywords: Androgen excess,


Hyperandrogenism affects 2-6% of all women. Hypertension is one of disturbances which is related to androgen excess. Higher intakes of vitamin C and vitamin E have been associated with lower blood pressure. Tho investigate the effect of these vitamin supplementation on blood pressure in hyperandrogenic women, a randomized, double-blind, placebo-controlled study was designed on 56 women 18-54 years old. Women were randomly allocated to one of four treatment groups: spironolactone plus vitamain C and viamin E (SCE), spironolactone plus vitamins placebo (SP), vitamin C plus vitamin E (CE), vitamins placebo (P). The treatment consisted of oral administration of 100 mg spironolactone, 1000 mg vitamin C and 900 mg vitamin E (alpha-tocopherol acetate) daily for about 3 months. Results indicated that compared to pretreatment, vitamins supplementation significantly lowered systolic (119.1±12.6 vs. 112.6±15.4 mmHg) and mean blood pressure (97.4±11.5 vs. 92. ±12.1 mmHg) SCE group (P<0.05), diastolic (87.3±12.7 vs. 80±12 mmHg) and mean group (P<0.05). Blood levels of vitamin C and alpha-tocopherol increased in all SCE and CE subjects. In conclusion, vitamin C and vitamin E supplementation reduced blood pressure in hperandrogenic women who are at risk of hypertension.
How to Cite
Sotoudeh G, Siassi F, Mirdamadi SR, Mohammad K, Golestan B, Chamari M. "Beneficial effects of vitamin C and vitamin E on blood pressure in Hyperandrogenic women &quot;. Acta Med Iran. 40(3):181-186.