A Young man with an Ulcerated Lesion on the Right Ankle

  • Kamran Balighi Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Khalil Farsinejad Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Mohamadreza Barzegar Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Naraghi Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Mohammad Ali Mortazavizadeh Resident of Dermatology; Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Sarcoma, epithelium, ankle

Abstract

We present a case of epitheloid sarcoma that was referred with a 2×3cm ulcerated lesion on the right ankle and edema of the lower leg. Foot drop of the right side was present that had caused walking difficulty. After a few months, he developed several sporthricoidal nodular lesions on the medial aspect of right thigh, inguinal lymphadenopathy, weight loss, anorexia and respiratory symptoms. Chest x-ray and HRCT showed pulmonary metastasis. Histopathological evaluation and immunohistochemical profile of both skin lesion and involved inguinal lymph node were consistent with epitheloid sarcoma. The case is interesting because as far as we know there has been no report of epitheloid sarcoma in literature presenting with foot drop and edema prior to obvious skin involvement.

References

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Engers R, Gabbert HE. Mechanisms of tumor metastasis: cell biological aspects and clinical implications. J Cancer Res Clin Oncol 2000;126(12):682-92.

Chase DR, Enzinger FM. Epithelioid sarcoma. Diagnosis, prognostic indicators, and treatment. Am J Surg Pathol 1985;9(4):241-63.

Spillane AJ, Thomas JM, Fisher C. Epithelioid sarcoma: The clinicopathologic complexities of this rare soft tissue sarcoma. Ann Surg Oncol 2000;7:218-25.

Arber DA, Kandalaft PL, Mehta P, Battifora H. Vimentinnegative epithelioid sarcoma. The value of an immunohistochemical panel that includes CD34. Am J Surg Pathol 1993;17(3):302-7.

How to Cite
1.
Balighi K, Farsinejad K, Barzegar M, Naraghi Z, Mortazavizadeh SMA. A Young man with an Ulcerated Lesion on the Right Ankle. Acta Med Iran. 48(1):72-74.
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Articles