Hepatitis-C and Hepatitis-B Co-Infections in Patients with Human Immunodeficiency Virus in Tehran, Iran

  • SeyedAhmad SeyedAlinaghi Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Sara Jam Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Farhad Mehrkhani Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Fattahi Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran. AND Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Duman Sabzvari Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Kourorian Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran. AND Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Hossain Jabbari Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Minoo Mohraz Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Hepatitis B virus, Hepatitis C virus, HIV, Seroepidemiologic studies

Abstract

We carried out a study to determine the seroprevalence of HBV and HCV infections in HIV positive patients at a main referral center for HIV/AIDS in Iran. Serum samples from 201 HIV positive patients referring to a referral center for HIV/AIDS were analyzed for the presence of some hepatitis B (HBsAg, anti-HBc, anti-HBs) and Hepatitis C (anti-HCV) markers, during 2004- 2005. HBsAg was positive in 27 patients (13.4%), anti-HBc was positive in 60 patients (29.8%) and anti-HBs in 23 patients (11.4%). Anti-HCV Ab was positive in 135 of 201 (67.2%). HBV and HCV coinfection was observed in 73 of 201 (36.3%). The maximum prevalence of HBV-HIV and HCV-HIV coinfections were seen in intravenous drug users; 61.2% and 85.1%, respectively (P

References

Kumarasamy N, Vallabhaneni S, Flanigan TP, Mayer KH, Solomon S. Clinical profile of HIV in India. Indian J Med Res 2005;121(4):377-94.

Rathi PM, Amarapurkar DN, Borges NE, Koppikar GV, Kalro RH. Spectrum of liver diseases in HIV infection. Indian J Gastroenterol 1997;16(3):94-5.

Report on the Global AIDS Epidemic 2006. [Online] 2006 Jun [cited 2011 Apr]; Available from:URL:http://data.unaids.org/pub/GlobalReport/2006/2006_ gr_ch02_en.pdf

Alter MJ. Epidemiology of viral hepatitis and HIV coinfection. J Hepatol 2006;44(1 Suppl):S6-9.

Puoti M, Airoldi M, Bruno R, Zanini B, Spinetti A, Pezzoli C, Patroni A, Castelli F, Sacchi P, Filice G, Carosi G. Hepatitis B virus co-infection in human immunodeficiency virus-infected subjects. AIDS Rev 2002;4(1):27-35.

Kellerman SE, Hanson DL, McNaghten AD, Fleming PL. Prevalence of chronic hepatitis B and incidence of acute hepatitis B infection in human immunodeficiency virusinfected subjects. J Infect Dis 2003;188(4):571-7.

Rockstroh JK. Management of hepatitis B and C in HIV co-infected patients. J Acquir Immune Defic Syndr 2003;34 Suppl 1:S59-65.

Dodig M, Tavill AS. Hepatitis C and humanimmunodeficiency virus coinfections. J Clin Gastroenterol 2001;33(5):367-74.

Tien PC; Veterans Affairs Hepatitis C Resource Center Program; National Hepatitis C Program Office. Management and treatment of hepatitis C virus infection in HIV-infected adults: recommendations from the Veterans Affairs Hepatitis C Resource Center Program and National Hepatitis C Program Office. Am J Gastroenterol 2005;100(10):2338-54.

Sungkanuparph S, Vibhagool A, Manosuthi W, Kiertiburanakul S, Atamasirikul K, Aumkhyan A, Thakkinstian A. Prevalence of hepatitis B virus and hepatitis C virus co-infection with human immunodeficiency virus in Thai patients: a tertiary-care-based study. J Med Assoc Thai 2004;87(11):1349-54.

Staples CT Jr, Rimland D, Dudas D. Hepatitis C in the HIV (human immunodeficiency virus) Atlanta V.A.(Veterans Affairs Medical Center) Cohort Study (HAVACS): the effect of coinfection on survival. Clin Infect Dis 1999;29(1):150-4.

Kumarasamy N, Solomon S, Flanigan TP, Hemalatha R, Thyagarajan SP, Mayer KH. Natural history of human immunodeficiency virus disease in southern India. Clin Infect Dis 2003;36(1):79-85.

Sud A, Singh J, Dhiman RK, Wanchu A, Singh S, Chawla Y. Hepatitis B virus co-infection in HIV infected patients. Trop Gastroenterol 2001;22(2):90-2.

Bhattacharya S, Badrinath S, Hamide A, Sujatha S. Coinfection with hepatitis C virus and human immunodeficiency virus among patients with sexually transmitted diseases in Pondicherry, South India. Indian J Pathol Microbiol 2003;46(3):495-7.

Saha MK, Chakrabarti S, Panda S, Naik TN, Manna B, Chatterjee A, Detels R, Bhattacharya SK. Prevalence of HCV & HBV infection amongst HIV seropositive intravenous drug users & their non-injecting wives in Manipur, India. Indian J Med Res 2000;111:37-9.

Amin J, Kaye M, Skidmore S, Pillay D, Cooper DA, Dore GJ. HIV and hepatitis C coinfection within the CAESAR study. HIV Med 2004;5(3):174-9.

Seme K, Poljak M, Begovac J, Vince A, Tomazic J, Vidmar L, Kniewald T. Low prevalence of hepatitis C virus infection among human immunodeficiency virus type 1-infected individuals from Slovenia and Croatia. Acta Virol 2002;46(2):91-4.

Tovo CV, Dos Santos DE, de Mattos AZ, de Almeida PR, de Mattos AA, Santos BR. Ambulatorial prevalence of hepatitis B and C markers in patients with human immunodeficiency virus infection in a general hospital. Arq Gastroenterol 2006;43(2):73-6.

Ockenga J, Tillmann HL, Trautwein C, Stoll M, Manns MP, Schmidt RE. Hepatitis B and C in HIV-infected patients. Prevalence and prognostic value. J Hepatol 1997;27(1):18-24.

Anthony SF, Clifford HL. Human immunodeficiency virus (HIV) disease: AIDS and related disorders. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors. 16th ed. Harrison’s Principles of InternalMedicine. New York, NY: McGraw-Hill; 2005. p. 1111.

Francisci D, Baldelli F, Papili R, Stagni G, Pauluzzi S. Prevalence of HBV, HDV and HCV hepatitis markers in HIV-positive patients. Eur J Epidemiol 1995;11(2):123-6.

Gupta S, Singh S. Hepatitis B and C virus co-infections in human immunodeficiency virus positive North Indianpatients. World J Gastroenterol 2006;12(42):6879-83.

Thomas DL, Zenilman JM, Alter HJ, Shih JW, Galai N, Carella AV, Quinn TC. Sexual transmission of hepatitis C virus among patients attending sexually transmitted diseases clinics in Baltimore--an analysis of 309 sex partnerships. J Infect Dis 1995;171(4):768-75.

Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, Meehan MO, Lutalo T, Gray RH. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000;342(13):921-9.

Osmond DH, Padian NS, Sheppard HW, Glass S, Shiboski SC, Reingold A. Risk factors for hepatitis C virus seropositivity in heterosexual couples. JAMA 1993;269(3):361-5.

Alter MJ, Hadler SC, Judson FN, Mares A, Alexander WJ, Hu PY, Miller JK, Moyer LA, Fields HA, Bradley DW, et al. Risk factors for acute non-A, non-B hepatitis in the United States and association with hepatitis C virus infection. JAMA 1990;264(17):2231-5.

Terrault NA. Sexual activity as a risk factor for hepatitis C. Hepatology 2002;36(5 Suppl 1):S99-105.

Bräu N. Treatment of chronic hepatitis C in humanimmunodeficiency virus/hepatitis C virus-coinfected patients in the era of pegylated interferon and ribavirin. Semin Liver Dis 2005;25(1):33-51.

Vallet-Pichard A, Pol S. Natural history and predictors of severity of chronic hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection. J Hepatol. 2006;44(1 Suppl):S28-34.

Puoti M, Torti C, Bruno R, Filice G, Carosi G. Natural history of chronic hepatitis B in co-infected patients. J Hepatol 2006;44(1 Suppl):S65-70.

Scharschmidt BF, Held MJ, Hollander HH, Read AE, Lavine JE, Veereman G, McGuire RF, Thaler MM. Hepatitis B in patients with HIV infection: relationship to AIDS and patient survival. Ann Intern Med 1992;117(10):837-8. No abstract available.

Herrero ME. Hepatitis B and hepatitis C co-infection in patients with HIV. Rev Med Virol 2001;11(4):253-70.

How to Cite
1.
SeyedAlinaghi S, Jam S, Mehrkhani F, Fattahi F, Sabzvari D, Kourorian Z, Jabbari H, Mohraz M. Hepatitis-C and Hepatitis-B Co-Infections in Patients with Human Immunodeficiency Virus in Tehran, Iran. Acta Med Iran. 49(4):252-257.
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