Bilateral primary breast lymphoma in a teenage girl with multi-organ involvement.

  • Masoud Poureisa Neurosciences Research Center, Department of Radiology, Radiotherapy and Nuclear Medicine, Tabriz Medical Science University, Tabriz, Iran.
  • Mohammad Hossein Daghighi Department of Radiology, Radiotherapy and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ramin Mazaheri-Khameneh Department of Clinical Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
  • Ali Ghadirpour Department of Radiology, Radiotherapy and Nuclear Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Keywords: Breast, Central nervous system, Primary lymphoma, Radiology

Abstract

We present 16 years old girl with primary breast lymphoma involving the both breasts simultaneously and co-incidence of central nervous system (CNS) involvement which originated from the breast, in addition to evidence of lymphoma in multi-organ such as skin, mediastinum and some abdominal viscera. Bilaterality has been observed in some series, but reports are few and series are often very small. Radiologic features may be indistinguishable from those of the other breast malignancies, but it can be concluded that primary involvement of the breast with lymphoma should be considered when breast mass or inflammatory changes occur in a patient without any previously diagnosed lymphoma. The clinical behavior, imaging and therapeutic procedures are discussed. The findings of this report may have clinical impact on oncologists or that may alter the disease concept of bilateral breast lymphoma.

References

Dawn B, Perry MC. Bilateral non-Hodgkin's lymphoma of the breast mimicking mastitis. South Med J 1997;90(3):328-9.

Harkin DW, Somerville J, Stokes M. Primary breast lymphoma. Ulster Med J 1998;67(1):61-2.

Yamazaki H, Hanada M, Kitada M, Kuyama J, Sato T, Nishikubo M, Ishida T, Inoue T, Inoue T. Four cases of central nervous system involvement of breast malignant lymphoma. Jpn J Clin Oncol 2003;33(8):399-403.

Cohen PL, Brooks JJ. Lymphomas of the breast, a clinicopathologic and immunohistochemical study of primary and secondary cases. Cancer 1991;67(5):1359-69.

Paes FM, Kalkanis DG, Sideras PA, Serafini AN. FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics 2010;30(1):269-91.

Ariad S, Lewis D, Cohen R, Bezwoda WR. Breastlymphoma. A clinical and pathological review and 10-year treatment results. S Afr Med J 1995;85(2):85-9.

Kitawaki T, Yonetani N, Akasaka H, Akasaka T, Ohno H, Okuma M. Non-Hodgkin's lymphoma involving bilateral breasts. Intern Med 1998;37(3):311-5.

Au WY, Chan ACL, Liang R. Lymphoma of the breast in Hong Kong Chinese. Hematol Oncol 1997;15(1):33–8.

Jeon HJ, Akagi T, Hoshida Y, Hayashi K, Yoshino T, Tanaka T, Ito J, Kamei T, Kawabata K. Primary non-Hodgkin malignant lymphoma of the breast. An immunohistochemical study of seven patients andliterature review of 152 patients with breast lymphoma in Japan. Cancer 1992;70(10):2451-9.

Ribrag V, Bibeau F, El Weshi A, Frayfer J, Cebotaru C, Laribi K, Fenaux P. Primary breast lymphoma: a report of 20 cases. Brit J Haematol 2001;115(2):253–6.

Liberman L, Giess CS, Dershaw DD, Louie DC, Deutch BM. Non-Hodgkin lymphoma of the breast: imaging characteristics and correlation with histopathologic findings. Radiology 1994;192(1): 157-60.

Naganawa S, Endo T, Aoyama H, Ichihara S. MR lmaging of the Primary Breast Lymphoma: A Case Report. Breast Cancer 1996;3(3):209-13.

Mussurakis S, Carleton PJ, Turnbull LW. MR imaging ofprimary non-Hodgkin's breast lymphoma. A case report. Acta Radiol 1997;38(1):104-7.

Irshad A, Ackerman SJ, Pope TL, Moses CK, Rumboldt T, Panzegrau B. Rare breast lesions: correlation of imaging and histologic features with WHO classification. Radiographics 2008;28(5): 1399-414.

How to Cite
1.
Poureisa M, Daghighi MH, Mazaheri-Khameneh R, Ghadirpour A. Bilateral primary breast lymphoma in a teenage girl with multi-organ involvement. Acta Med Iran. 51(8):572-576.
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