Acta Medica Iranica 2014. 52(8):601-606.

Assessment of vitamin D plasma levels in patients with vitiligo vulgaris.
Akram Beheshti, Hodda Ghadami, Ameneh Barikani, Fatemeh Haj Manouchehri

Abstract


Vitiligo Vulgaris is a pigment disorder as the lack of skin pigmentation which its most prevalent cause is autoimmune. Vitamin D has various effects on the natural and acquired immune of the body because of its effectiveness on the T cells and B cells, macrophages and dendritic cells.The object of this study was assessment of the Vitamin D in patients with vitiligo vulgaris in dermatologic clinics in Qazvin in 2012. The 100 patients with Vitiligo were studied through a cross-sectional study. The required data were collected by the questionnaire (age, gender, job, family background, consumption of the dairies and vitamin D supplements), examination (type of skin) and para clinical test (measurement of the serum 25-hydroxyvitamin D level). The 42 (42%) and 58 (58%) people of the population under study were respectively male and female. The mean age of the population under study was 28.7±1.17. The mean serum of 25-hydroxyvitamin D level was 42±24.14 which had a significance difference with a normal level (p<0.04). The mean serum 25-hydroxyvitamin D level among patients with Vitiligo had a significance difference with a normal level.

Keywords


Vitamin D; Vitiligo Vulgaris; Iran; Plasma level; Patients

Full Text:

PDF

References


Alkhateeb A, Fain PR, Thody A, et al. Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res 2003;16(3):208-14.

Nath SK, Majumder PP, Nordlund JJ. Genetic epidemiology of vitiligo:multilocus recessivity crossvalidated. Am J Hum Genet 1994;55(5):981-90.

Sun X, Xu A, Wei X, et al. Genetic epidemiology of vitiligo:a study of 815 probands and their families from south China. Int J Dermatol 2006;45(10):1176-81.

Ongenae K, Van Geel N, Naeyaert JM. Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res 2003;16(2):90-100.

van den Wijngaard R, Wanknowics-Kalinska A, et al. Local immune response in skin of generalized vitiligo patients. Destruction of melanocytes is associated with the prominent presence of CLA+ T cells at the perilesional site. Lab Invest 2000;80(8):1299-309.

Kurtev A, Dourmishev Al. Thyroid function and autoimmunity in children and adolescents with vitiligo. J Eur Acad Dermatol Venereol 2004;18(1):109-11.

Akay BN, Bozkir M, Anadolu Y, et al. Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey. J Eur Acad Dermatol Venereol. 2010 Oct;24(10):1144-50.

Taieb A, Picardo M, VETF Members. The definition and assessment of vitiligo:a consensus report of the Vitiligo European Task Force. Pigment Cell Res 2007;20(1):27-35.

Lu T, Gao T, Wang A, et al. Vitiligo prevalence study in Shaanxi Province, China. Int J Dermatol 2007;46(1):47-51.

Howitz J, Brodthagen H, Schwartz M, et al. Prevalence of vitiligo. Epidemiological survey on the Isle of Bornholm, Denmark. Arch Dermatol 1977;113(1):47-52.

Das SK, Majumder PP, Chakraborty R, et al. Studies on vitiligo. I. Epidemiological profile in Calcutta, India. Genet Epidemiol 1985;2(1):71-8.

Dwivedi M, Laddha NC, Shajil EM, et al. The ACE gene I/ D polymorphism is not associated with generalized vitiligo susceptibility in Gujarat population. Pigment Cell Melanoma Res 2008;21(3):407-8.

Das SK, Majumder PP, Chakraborty R, et al. Studies on vitiligo. I. Epidemiological profile in Calcutta, India. Genet Epidemiol 1985;2(1):71-8.

Dogra S, Parsad D, Handa S, et al. Late onset vitiligo:a study of 182 patients. Int J Dermatol 2005;44(3):193-6.

Onunu AN, Kubeyinje EP. Vitiligo in the Nigerian African:a study of 351 patients in Benin City, Nigeria. Int J Dermatol 2003;42(10):800-2.

Halder RM, Taliaferro SJ. Vitiligo. In:Wolff K, Goldsmith L, Katz S, et al, editors. Fitzpatrick’s dermatology in general medicine. 7th ed. New York:McGraw-Hill;2008:p.72.

Kyriakis KP, Palamaras I, Tsele E, et al. Case detection rates of vitiligo by gender and age. Int J Dermatol 2009;48(3):328-9.

Tamer E, Ilhan MN, Polat M, et al. Prevalence of skin diseases among pediatric patients in Turkey. J Dermatol 2008;35(7):413-8.

Galus R, Zandecki L, Sajjad E, et al. Factors affecting melanogenesis and methods used for identification of pigmentation disorders. Pol Merkur Lekarski 2008;25(146):188-91.

Burns T, Breathnach S, Cox N, et al, editors. Rook textbook of dermatology. 7th ed. Oxford, UK: Blackwell Publishing; 2004: p. 39.

Porter JR, Beut AH, Lerner A, et al. Psychosocial effect of vitiligo:a comparison of vitiligo patients with "normal" control subjects, with psoriasis patients, and with patients with other pigmentary disorders. J Am Acad Dermatol 1986;15(2 Pt 1):220-4.

Porter J, Beuf AH, Nordlund JJ, et al. Psychological reaction to chronic skin disorders: a study of patients with vitiligo. Gen Hosp Psychiatry 1979;1(1):73-7.

Nordlund JJ, Majumder PP. Recent investigations on vitiligo volgaris. Dermatol Clin 1997;15(1):69-78.

Holick MF. Vitamin D:a millenium perspective. J Cell Biochem 2003;88(2):296-307.

Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab 2009;94(1):26-34.

Johnson JA, Grande JP, Roche PC, et al. Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol 1994;267(3 Pt 1):E356-60.

Lemire JM. Immunomodulatory actions of 1, 25- dihydroxyvitaminD3. J Steroid Biochem Mol Biol 1995;53(1-6):599-602.

Mauricio D, Mandrup-Poulsen T, Nerup J. Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases:a therapeutic perspective. Diabetes Metab Rev 1996;12(1):57-68.

Overbergh L, Decallonne B, Valckx D, et al. Identification and immune regulation of 25-hydroxyvitamin D-1-alphahydroxylase in murine macrophages. Clin Exp Immunol 2000;120(1):139-46.

Adorini L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 2008;4(8):404-12.

Iacovelli P, Sinagra JL, Vidolin AP, et al. Relevance of thyroiditis and of other autoimmune diseases in children with vitiligo. Dermatology 2005;210(1):26-30.

Zhang Z, Xu SX, Zhang FY, et al. The analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients. Arch Dermatol Res 2009;301(2):167-73.

Artantas S, Gul U, Kilic A, et al. Skin findings in thyroid diseases. Eur J Intern Med 2009;20(2):158-61.

Silverberg JI, Silverberg AI, Malka E, et al. A pilot study assessing the role of 25 hydroxy vitamin D levels in patients with vitiligo vulgaris. J Am Acad Dermatol 2010;62(6):937-41.

Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 2007;103(3-5):620-5.

Moradzadeh K, Larijani B, Keshtkar A, et al. Normative Values of Vitamin D Among Iranian Population:A Population Based Study. Int J Osteoporos Metab Disord 2008;1(2):8-15.

Frati R, Frati C, Sassano PP, et al. Vitiligo, autoimmune thyroiditis:a rare thyroid cancer arising with bone metastates on maxillofacial area. J Exp Clin Cancer Res, 1999;18(1):85-7.


Refbacks

  • There are currently no refbacks.


Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.