Co-existence of cutaneous leishmaniasis with pleural effusion: a case report from Iran.
AbstractHerein, a 12-year-old Afghan boy with chronic cutaneous leishmaniasis on the face and verrucous lesions on the body and pleural effusion suspected of having co-existent tuberculosis has been presented. The cutaneous lesions were appeared for five years before his admission. Leishman-Donovan bodies were seen in H&E (Hematoxylin and eosin) slide of skin lesion specimens. The pathogenic species was proved to be Leishmania tropica using Polymerase Chain Reaction (PCR) method. Purified Protein Derivative (PPD) and Leishmanin Skin Test (LST) were strongly positive. The patient was treated with systemic and intralesional meglumine antimoniate (Glucantime) for cutaneous leishmaniasis and then with anti-tuberculosis drugs for pleural effusion. Afterwards, pleural effusion was disappeared and cutaneous leishmaniasis cured.
Vega-Lopez F, Hay RJ. Parasitic worms and protozoa. In:Burns T, Breathnach S, Cox N, et al, editors. Rook's textbook of dermatology. 8ed ed. Singapore: Wiley- Blackwell Publishing; 2010: p. 33-9.
Karamian M, Motazedian MH, Fakhar M, et al. Atypical presentation of Old-World cutaneous leishmaniasis, diagnosis and species identification by PCR. J Eur Acad Dermatol Venereol 2008;22(8):958-62.
Delobel P, Launois P, Djossou F, et al. American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response. Clin Infect Dis 2003;37(5):628-33.
Asilian A, Karbasioun S. Disseminated cutaneous Leishmaniasis with Tuberculous Dactylitis: A case report. Iranian J Dermatol 2004;8(29):1-2.
Pandey K, Sinha PK, Ravidas VN, et al. Nexus of infection with human immunodeficiency virus, pulmonary tuberculosis and visceral leishmaniasis:a case report from Bihar, India. Am J Trop Med Hyg 2005;72(1):30-2.
Das VN, Pandey K, Kumar N, et al. Visceral leishmaniasis and tuberculosis in patients with HIV co-infection. Southeast Asian J Trop Med Public Health 2006;37(1):18-
el-Safi SH, Hamid N, Omer A, et al. Infection rates with Leishmania donovani and Mycobacterium tuberculosis in a village in eastern Sudan. Trop Med Intl Health 2004;9(12):1305-11.
Toledo AC Jr, de Castro MR. Pneumocystis carinii pneumonia, pulmonary tuberculosis and visceral leishmaniasis in an adult HIV negative patient. Braz JInfect Dis 2001;5(3):154-7.
Pérez-Molina JA, Torres L, Ruiz MJ, et al. Lack ofsignificant crossreactivity between Leishmania serology and mycobacteriosis in patients infected with HIV-1. Clin Microbiol Infect 1999;5(5):253-5.
Marques N, Cabral S, Sá R, et al. Visceral leishmaniasis and HIV infection in the HAART era. Acta Med Port 2007;20(4):291-8.
Alvar J, Cañavate C, Gutierrez-Solar B, et al. Leishmania and human immunodeficiency virus coinfection:the first 10 years. Clin Microbiol Rev 1997;10(2):298-319.
Rathnayake D, Ranawake RR, Sirimanna G, et al. Coinfection of mucosal leishmaniasis and extra pulmonary tuberculosis in a patient with inherent immune deficiency. Int J Dermatol 2010;49(5):549-51.