White Sponge Nevus: Report of a Case and Review of the Literature

  • Mohammadreza Sobhan Department of Dermatology, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Pedram Alirezaei Department of Dermatology, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Mahmood Farshchian Department of Dermatology, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Gholamreza Eshghi Department of Dermatology, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Hamid Reza Ghasemi Basir Department of Pathology, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Leila Khezrian Department of Dermatology, Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Keywords: Oral mucosa, White sponge nevus, White lesions

Abstract

White sponge nevus is a rare benign autosomal dominant disorder with variable penetrance. It is characterized by asymptomatic white plaques affecting mainly the oral mucosa. Careful clinical and histopathological examination is indicated to exclude other more serious conditions presenting as oral white lesions. Herein, we present a new case of oral white sponge nevus in a 17-year-old Iranian male with no familial background.

References

Jorgenson RJ, Levin S. White sponge nevus. Arch Dermatol 1981;117(2):73-6.

Lopez Jornet P. White sponge nevus: presentation of a new family. Pediatr Dermatol 2008;25(1):116-7.

Cai W, Chen Z, Jiang B, et al. Keratin 13 mutations associated with oral white sponge nevus in two Chinese families. Meta Gene 2014;2:374-83.

Chao SC, Tsai YM, Yang MH, Lee JY. A novel mutation in the keratin 4 gene causing white sponge naevus. Br J Dermatol 2003;148(6):1125-8.

Kimura M, Nagao T, Machida J, Warnakulasuriya S. Mutation of keratin 4 gene causing white sponge nevus in a Japanese family. Int J Oral Maxillofac Surg 2013;42(5):615-8.

McGowan KA, Fuchs H, Hrabe de Angelis M, Barsh GS. Identification of a Keratin 4 mutation in a chemically induced mouse mutant that models white sponge nevus. J Invest Dermatol 2007;127(1):60-4.

Richard G, De Laurenzi V, Didona B, et al. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. Nat Genet 1995;11(4):453-5.

Rugg EL, McLean WH, Allison WE, et al. A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. Nat Genet 1995;11(4):450-2.

Marrelli M, Tatullo M, Dipalma G, Inchingolo F. Oral infection by Staphylococcus aureus in patients affected by White Sponge Nevus: a description of two cases occurred in the same family. Int J Med Sci 2012;9(1):47-50.

Aghbali A, Pouralibaba F, Eslami H, et al. White sponge nevus: a case report. J Dent Res Dent Clin Dent Prospects 2009;3(2):70-2.

Shibuya Y, Zhang J, Yokoo S, et al. Constitutional mutation of keratin 13 gene in familial white sponge nevus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;96(5):561-5.

Dadlani C, Mengden S, Kerr AR. White sponge nevus. Dermatol Online J 2008;14(5):16.

Schaarschmidt H, Wollina U, Roth H. [Nevus spongiosus et albus mucosae]. Hautarzt 1992;43(1):35-7.

Songu M, Adibelli H, Diniz G. White sponge nevus: clinical suspicion and diagnosis. Pediatr Dermatol 2012;29(4):495-7.

Liu X, Li Q, Gao Y, et al. Mutational analysis in familial and sporadic patients with white sponge naevus. Br J Dermatol 2011;165(2):448-51.

Zhang JM, Yang ZW, Chen RY, et al. Two new mutations in the keratin 4 gene causing oral white sponge nevus in Chinese family. Oral Dis 2009;15(1):100-5.

Cox MF, Eveson J, Porter SR, et al. Human papillomavirus type 16 DNA in oral white sponge nevus. Oral Surg Oral Med Oral Pathol 1992;73(4):476-8.

McDonagh AJ, Gawkrodger DJ, Walker AE. White sponge naevus successfully treated with topical tetracycline. Clin Exp Dermatol 1990;15(2):152-3.

O'Leary P, Montgomery H, Brunsting L, Kierland R. White sponge nevus: moniliasis. Arch Dermatol Syphilol 1950;62:608.

Lim J, Ng SK. Oral tetracycline rinse improves symptoms of white sponge nevus. J Am Acad Dermatol 1992;26(6):1003-5.

Otobe IF, de Sousa SO, Matthews RW, Migliari DA. White sponge naevus: improvement with tetracycline mouth rinse: report of four cases. Clin Exp Dermatol 2007;32(6):749-51.

Satriano RA, Errichetti E, Baroni A. White sponge nevus treated with chlorhexidine. J Dermatol 2012;39(8):742-3.

Downham TF, Jr., Plezia RA. Oral squamous-cell carcinoma within a white-sponge nevus. J Dermatol Surg Oncol 1978;4(6):470-2.

Published
2017-10-07
How to Cite
1.
Sobhan M, Alirezaei P, Farshchian M, Eshghi G, Ghasemi Basir HR, Khezrian L. White Sponge Nevus: Report of a Case and Review of the Literature. Acta Med Iran. 55(8):533-535.
Section
Case Report(s)