Bowen's Disease Associated With Two Human Papilloma Virus Types

  • Hojat Eftekhari Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Kaveh Gharaei Nejad Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Seyyede Zeinab Azimi Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Rana Rafiei Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Alireza Mesbah Razi Clinico-Pathology Laboratory, Rasht, Iran.
Keywords: Bowen's disease, Human papilloma virus, Squamous cell carcinoma

Abstract

Bowen's disease (BD) is an epidermal in-situ squamous cell carcinoma (SCC). Most Human Papilloma Viruses (HPV)-positive lesions in Bowen's disease are localized to the genital region or distal extremities (periungual sites) in which HPV type-16 is frequently detected. Patient was a 64-year-old construction worker for whom we detected 2 erythematous psoriasiform reticular scaly plaques on peri-umbilical and medial knee. Biopsy established the diagnosis of Bowen's disease and polymerase chain reaction assay showed HPV-6, -18 co-infection. Patient was referred for surgical excision.

Author Biographies

Hojat Eftekhari, Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Assistant professor, Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Rana Rafiei, Department of Dermatology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

.

References

Weyers W. The centennial of Bowen’s disease a critical review on the occasion of he 100th anniversary of its original description. Dermatol Pract Concept 2012;2:2.

Murao K, Yoshioka R, Kubo Y. Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16INK4a over expression, is correlated with human papillomavirus-associated Bowen disease. J Dermatol 2014;41:878-84.

Hama N, Ohtsuka T, Yamazaki S. Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen’s disease and squamous cell carcinoma of the skin. J Dermatol 2006;33:331-7.

Shimizu A, Tamura A, Abe M. Human papillomavirus type 56-associated Bowen disease. Br J Dermatol 2012;167:1161-4.

Harwood CA, Proby CM. Human papillomaviruses and non-melanoma skin cancer. Curr Opin Infect Dis 2002;15:101-14.

Kirnbauer R, Lenz P, Human Papillomaviruses. In: Bolognia J, Jorizzo J, Schaffer J. D, editors. Dermatology. 3rd ed. China: Elsevier Saunders, 2012:1307-9.

Yu HS, Liao WT, Chai CY. Arsenic carcinogenesis in the skin. J Biomed Sci 2006;13:657-66.

Morton CA, Birnie AJ, Eedy DJ. British Association of Dermatologists’ guidelines for the management of squamous cell carcinoma in situ (Bowen’s disease). Br J Dermatol 2014;170:245-60.

Firooz A, Farsi N, Rashighi- Firoozabadi M, Gorouhi F. Pigmented Bowen's disease of the finger mimicking malignant melanoma. Arch Iranian Med 2007;10:255-7.

Hama N, Ohtsuka T, Yamazaki S. Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen's diseaseand squamous cell carcinoma of the skin. J Dermatol 2006;33:331-7

Published
2017-10-30
How to Cite
1.
Eftekhari H, Gharaei Nejad K, Azimi SZ, Rafiei R, Mesbah A. Bowen’s Disease Associated With Two Human Papilloma Virus Types. Acta Med Iran. 55(9):594-596.
Section
Case Report(s)