Acta Medica Iranica 2017. 55(9):594-596.

Bowen's Disease Associated With Two Human Papilloma Virus Types
Hojat Eftekhari, Kaveh Gharaei Nejad, Seyyede Zeinab Azimi, Rana Rafiei, Alireza Mesbah


Bowen's disease (BD) is an epidermal in-situ squamous cell carcinoma (SCC). Most Human Papilloma Viruses (HPV)-positive lesions in Bowen's disease are localized to the genital region or distal extremities (periungual sites) in which HPV type-16 is frequently detected. Patient was a 64-year-old construction worker for whom we detected 2 erythematous psoriasiform reticular scaly plaques on peri-umbilical and medial knee. Biopsy established the diagnosis of Bowen's disease and polymerase chain reaction assay showed HPV-6, -18 co-infection. Patient was referred for surgical excision.


Bowen's disease; Human papilloma virus; Squamous cell carcinoma

Full Text:



Weyers W. The centennial of Bowen’s disease a critical review on the occasion of he 100th anniversary of its original description. Dermatol Pract Concept 2012;2:2.

Murao K, Yoshioka R, Kubo Y. Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16INK4a over expression, is correlated with human papillomavirus-associated Bowen disease. J Dermatol 2014;41:878-84.

Hama N, Ohtsuka T, Yamazaki S. Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen’s disease and squamous cell carcinoma of the skin. J Dermatol 2006;33:331-7.

Shimizu A, Tamura A, Abe M. Human papillomavirus type 56-associated Bowen disease. Br J Dermatol 2012;167:1161-4.

Harwood CA, Proby CM. Human papillomaviruses and non-melanoma skin cancer. Curr Opin Infect Dis 2002;15:101-14.

Kirnbauer R, Lenz P, Human Papillomaviruses. In: Bolognia J, Jorizzo J, Schaffer J. D, editors. Dermatology. 3rd ed. China: Elsevier Saunders, 2012:1307-9.

Yu HS, Liao WT, Chai CY. Arsenic carcinogenesis in the skin. J Biomed Sci 2006;13:657-66.

Morton CA, Birnie AJ, Eedy DJ. British Association of Dermatologists’ guidelines for the management of squamous cell carcinoma in situ (Bowen’s disease). Br J Dermatol 2014;170:245-60.

Firooz A, Farsi N, Rashighi- Firoozabadi M, Gorouhi F. Pigmented Bowen's disease of the finger mimicking malignant melanoma. Arch Iranian Med 2007;10:255-7.

Hama N, Ohtsuka T, Yamazaki S. Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen's diseaseand squamous cell carcinoma of the skin. J Dermatol 2006;33:331-7


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.