Dermatologic manifestations in HTLV-1-associated myelopathy/tropical spastic paraparesis
Background: The human T cell lymphotropic virus type-1 ( HTLV-1) is associated with adult T cell leukemia/lymphoma (ATL) and other disorders, including a slowly progressive demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic paraparesis ( HAM/TSP). Dermatologic manifestations are common in patients infected with HTLV-1 infection. In this study, we evaluated the dermatologic lesions associated with HAM/TSP patients in Mashhad.
Methods: Dermatological findings of 37 patients with HAM/TSP were investigated and were compared with those of a HTLV-1 negative control group. Cutaneous biopsy was performed as needed and the results were statistically analyzed.
Result: Results of the present study showed that 34 cases with HAM/TSP (91.9%) and 24 cases in control group (64.9%) had at least one skin lesion or history of skin lesion before (p=0.010). Xerosis was found in 22 persons (59.5%) in the case group and 4 persons in the control group (10.8%) (p=0.000). Only Xerosis was significantly associated with HAM/TSP.
Conclusion: Skin manifestations were quite frequent in the patients with HAM/TSP. Xerosis was significantly associated with HAM/TSP.
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