Dermatologic manifestations in HTLV-1-associated myelopathy/tropical spastic paraparesis

  • Reza Boostani Department of Neurology, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Pouran Layegh
  • Mohammad Javad Yazdanpanah Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Elham Vosoughi
  • Azadeh Mohammadi
  • Noseibe Joneidi
  • Reyhaneh Bazargani
  • Delaram Sayadpour Zanjani
  • Saeed Ebrahimzadeh
Keywords: HTLV-1, HTLV-1 Associated Myelopathy (HAM), Tropical spastic paraparesis (TSP), Skin Lesions

Abstract

Background: The human T cell lymphotropic virus type-1 ( HTLV-1) is associated  with  adult  T cell  leukemia/lymphoma (ATL) and other  disorders, including  a slowly progressive  demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic  paraparesis  ( HAM/TSP). Dermatologic manifestations are common in patients infected with HTLV-1 infection. In this study, we evaluated the dermatologic lesions associated with HAM/TSP patients in Mashhad.

Methods: Dermatological  findings  of  37  patients  with  HAM/TSP  were  investigated  and  were  compared  with  those of a  HTLV-1 negative control  group. Cutaneous biopsy was performed as needed and the results were statistically analyzed.

Result: Results of the present study showed that 34 cases with HAM/TSP (91.9%) and 24 cases in control group (64.9%) had at least one skin lesion or history of skin lesion before (p=0.010). Xerosis was found in 22 persons (59.5%) in the case group and 4 persons in the control group (10.8%) (p=0.000). Only Xerosis was significantly associated with HAM/TSP.  

Conclusion: Skin manifestations were quite frequent in the patients with HAM/TSP. Xerosis was significantly associated with HAM/TSP.

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Published
2019-05-13
How to Cite
1.
Boostani R, Layegh P, Yazdanpanah MJ, Vosoughi E, Mohammadi A, Joneidi N, Bazargani R, Sayadpour Zanjani D, Ebrahimzadeh S. Dermatologic manifestations in HTLV-1-associated myelopathy/tropical spastic paraparesis. Acta Med Iran. 57(3):180-183.
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Articles