Evaluation of the Relationship Between Childhood Asthma and Helicobacter pylori Sero-Prevalence

  • Rasoul Nasiri Lung Diseases and Allergy Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. AND Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Pedram Ataee Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. AND Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Azad Abdi Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Ghobad Moradi Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. AND Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Borhan Moradveisi Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Kambiz Eftekhari Department of Pediatrics, Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Asthma, Children, Helicobacter pylori sero-prevalence, H. pylori-specific antibody (IgG)

Abstract

In recent years, the prevalence of asthma and allergic rhinitis has increased in developed countries. Helicobacter pylori (H. pylori) infection can exacerbate asthma. The purpose of this study was to investigate the relationship between asthma and H. pylori seroprevalence in children. In this cross-sectional study, 100 children aged 5-15 years hospitalized in Besat hospital in Sanandaj were investigated from 2015 to 2016. Fifty children with asthma were considered as the case group and 50 non-asthmatic children as the control group. The questionnaires were completed, including demographic information, history of asthma, exposure to cigarette smoke, and family history of gastric and duodenal ulcers. Blood samples were collected from the children, and the serum level of specific antibodies (IgG) of H. pylori was measured. There were 42 and 31 boys in the case and control group, respectively. The mean age in the case group was 8.12±2.29 and in the control group was 8.9±2.52 years. In the case group, 48% were exposed to cigarette smoke and in the control group, 18%. There was a statistically significant difference between the groups in terms of gender and exposure to cigarette smoke (P=0.001 and P=0.013, respectively). There was no significant difference between the case and control groups in terms of H. pylori seroprevalence. (P=0.211). There was no significant association between asthma and H. pylori seroprevalence. (P=0.22). According to our study, there no correlation between childhood asthma and H. pylori seroprevalence.

References

Trzcieniecka-Green A, Bargiel-Matusiewicz K, Wilczynska-Kwiatek A. Quality of life and activity of children suffering from bronchial asthma. Eur J Med Res. 2009;14(4):147-50.

Ricci G, Dondi A, Baldi E, Bendandi B, Giannetti A, Masi M. Use of the Italian version of the Pediatric Asthma Quality of Life Questionnaire in the daily practice: results of a prospective study. BMC pediatr. 2009;9(30):1-8. DOI.org/10.1186/1471-2431-9-30.

Farajzadeh S, Esfandiarpour I, Amini-Ranjbar S, Darvish-Damavandi F, Kamyabi Z, Vares B, et al. A survey on Helicobacter pylori seropositivity status in Iranian children with atopic dermatitis. Journal of Pakistan Association of Dermatologists. 2013;23(1):34-8.

Eder W, Ege MJ, Mutius E. The asthma epidemic. N Engl J Med. 2006;355:2226-35. DOI: 10.1056/NEJMra054308.

Chen Y, Blaser MJ. Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med. 2007;167(8):821-7. DOI: 10.1001/archinte.167.8.821.

Jun ZJ, Lei Y, Shimizu Y, Dobashi K, Mori M. Helicobacter pylori seroprevalence in patients with mild asthma. Tohoku J Exp Med. 2005;207(4):287-91.

Arram EO, Shahin DA, Sherif MM. Asthma is inversely associated with Helicobacter pylori status. Egypt J Chest Dis Tuberc. 2012;61:41-5.

Blaser MJ, Chen Y, Reibman J. Does Helicobacter pylori protect against asthma and allergy? Gut. 2008;57(5):561-7. DOI: 10.1136/gut.2007.133462.

Wang Q, Yu C, Sun Y. The Association between Asthma and Helicobacter pylori: A Meta‐Analysis. Helicobacter. 2013;18(1):41-53. DOI: 10.1111/hel.12012.

Amedei A, Codolo G, Del-Prete G, Bernard M, D’Elios MM. The effect of Helicobacter pylori on asthma and allergy. J Asthma Allergy. 2010;3:139–47. DOI: 10.2147/JAA.S8971.

Chen Y, Blaser MJ. Helicobacter pylori colonization is inversely associated with childhood asthma. J Infec Dis. 2008;198(4):553-60. DOI: 10.1086/590158.

Wang Y, Bi Y, Zhang L, Wang C. Is Helicobacter Pylori Infection Associated with Asthma Risk?? A Meta-Analysis based on 770 Cases and 785 Controls. Int J Med Sci. 2012;9(7):603-10. DOI: 10.7150/ijms.4970.

Malfertheiner MV, Kandulski A, Schreiber J, Malfertheiner P. Helicobacter pylori infection and the respiratory system: a systematic review of the literature. Digestion. 2011;84:212-20. DOI: 10.1159/000329351.

Ribaldone DG, Fagoonee S, Colombini J, Saracco G, Astegiano M, Pellicano R. Helicobacter pylori infection and asthma: Is there a direct or an inverse association? A meta-analysis. World J Meta-Anal. 2016;4(3):63-8.

Bruce MG, Maaroos HI. Epidemiology of Helicobacter pylori infection. Helicobacter. 2008;13(s1):1-6. DOI: 10.1111/j.1523-5378.2008.00631.x.

Karimi A, Fakhimi-Derakhshan K, Imanzadeh F, Rezaei M, Cavoshzadeh Z, Maham S. Helicobacter pylori infection and pediatric asthma. Iran J Microbiol. 2013;5(2):132-5.

Tsang KW, Lam WK, Chan KN, Hu W, Wu A, Kwok E, et al. Helicobacter pylori sero-prevalence in asthma. Respir Med. 2000;94(8):756-9. DOI: 10.1053/rmed.2000.0817.

Jaber SM. Helicobacter pylori seropositivity in children with chronic disease in Jeddah, Saudi Arabia. Saudi J Gastroenterol. 2006;12(1):21-6.

Zevit N, Balicer RD, Cohen HA, Karsh D, Niv Y, Shamir R. Inverse Association Between Helicobacter pylori and Pediatric Asthma in a High-Prevalence Population. Helicobacter. 2012;17(1):30-5. DOI: 10.1111/j.1523-5378.2011.00895.x.

Den-Hollander WJ, Sonnenschein-vanderVoort AM, Holster IL, de-Jongste JC, Jaddoe VW, Hofman A, et al. Helicobacter pylori in children with asthmatic conditions at school age and their mothers. Aliment Pharmacol Ther. 2016;43(8):933-43.

Rauws EA, Langenberg W, Houthoff HJ, Zanen H, Tytgat GN. Campylobacter pyloridis-associated chronic active antral gastritis: a prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology. 1988;94(1):33-40.

Published
2019-09-30
How to Cite
1.
Nasiri R, Ataee P, Abdi A, Moradi G, Moradveisi B, Eftekhari K. Evaluation of the Relationship Between Childhood Asthma and Helicobacter pylori Sero-Prevalence. Acta Med Iran. 57(5):299-302.
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Articles