AUTORADIOGRAPHIC STUDY OF CORNEAL NEOVASCULARIZATION INDUCED BY ALKALINE BURN

Abstract

Corneal neovasculariuulon (CNJ1 can cause significant visual loss. The kinetics of endothelial cells durin{: microvascular growth were studied usinga model of alkaline cauteriuuion-induced neovascularization ofthe 40 rabbits cornea. Changes in DNA synthetic activity of endothelial cells during neovasculanuuion were assessed by autoradiographic studyojJJl_TdR incorporation, In vivo and In vitro. Microscopic study demonstrated that migration and redistribution of existing endothelial cells from the limbal vessels enabled vascular sprouting and elongation with cellular proliferation.