WARFARIN INDUCED MASSIVE AND BILATERAL SKIN NECROSIS OF THE BREASTS: A CASE REPORT AND REVIEW OF THE LITERATURES

Abstract

Warfarin induced skin necrosis is a rare complication associated with the use of oral ‎anticoagulants. Most patients develop this complication at the initiation of therapy. The complication is ‎usually associated with an underlying thrombophilia. Here we describe a case of a 75 year old ‎patient who developed skin necrosis in her both breasts during warfarin treatment for a ‎deep vein thrombosis. Thrombophilia screening demonstrated the presence of protein S and ‎antithrombin III deficiency. The necrotic lesion was excised and defects eventually ‎covered with skin flaps.