Familial Ankyloglossia (Tongue-tie): A Case Report
Abstract
Ankyloglossia (tongue-tie) is a congenital anomaly with a prevalence of 4-5% and characterized by an abnormally short lingual frenulum. For unknown reasons the abnormality seems to be more common in males. The pathogenesis of ankyloglossia is not known. The authors report a family with isolated ankyloglossia inherited as an autosomal dominant or recessive trait. The identification of the defective gene(s) in these patients might reveal novel information on the pathogenesis of this disorder.
Horton CE, Crawford HH, Adamson JE, Ashbell TS. Tongue-tie. Cleft Palate J 1969;6:8-23.
Lalakea ML, Messner AH. Ankyloglossia: does it matter? Pediatr Clin North Am 2003;50(2):381-97.
Messner AH, Lalakea ML. Ankyloglossia: controversies in management. Int J Pediatr Otorhinolaryngol 2000;54(2-3):123-31.
Harris EF, Friend GW, Tolley EA. Enhanced prevalence of ankyloglossia with maternal cocaine use. Cleft Palate Craniofac J 1992;29(1):72-6.
Messner AH, Lalakea ML, Aby J, Macmahon J, Bair E. Ankyloglossia: incidence and associated feeding difficulties. Arch Otolaryngol Head Neck Surg2000;126(1):36-9.
Ricke LA, Baker NJ, Madlon-Kay DJ, DeFor TA. Newborn tongue-tie: prevalence and effect on breast-feeding. J Am Board Fam Pract 2005;18(1):1-7.
Moore GE, Ivens A, Chambers J, Farrall M, Williamson R, Page DC, et al. Linkage of an X-chromosome cleft palate gene. Nature. 1987;326(6108):91-2.
Burdick AB, Ma LA, Dai ZH, Gao NN. van der Woude syndrome in two families in China. J Craniofac Genet Dev Biol 1987;7(4):413-8.
Braybrook C, Doudney K, Marçano AC, Arnason A, Bjornsson A, Patton MA, et al. The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia. Nat Genet 2001;29(2):179-83.
Morita H, Mazerbourg S, Bouley DM, Luo CW, Kawamura K, Kuwabara Y, et al. Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Mol Cell Biol 2004;24(22):9736-43.
Files | ||
Issue | Vol 48, No 2 (2010) | |
Section | Original Article(s) | |
Keywords | ||
Ankyloglossia tongue-tie inheritance patterns |
Rights and permissions | |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |