Random Urine Protein Creatinine Ratio as a Preadmission Test in Hypertensive Pregnancies with Urinary Protein Creatinine Ratio

  • Laleh Eslamian Mail Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Fariba Behnam Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Foroohesh Tehrani Department of Clinical laboratory and Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ashraf Jamal Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Vajiheh Marsoosi Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
Hypertensive pregnancies, Random, Protein creatinine ratio, Proteinuria

Abstract

To evaluate the value of random urinary protein creatinine ratio in prediction of 24h proteinuria in hypertensive pregnancies. Method: Random urine samples and routine 24h urine collections were collected from hypertensive pregnant women (n=100). Reliability of random urinary protein–creatinine ratio was assessed by receiver operator characteristic (ROC) curve to detect significant proteinuria (300mg/day) using 24h. Urine protein as a gold standard. Forty six patients (46%) had significant proteinuria. The random protein creatinine ratio was correlated to 24h urine protein excretion (r2 =0.777, P<0.001) Area under ROC curve to predict proteinuria was 0.926 (95% CI: 0.854–0.995, P<0.001). A cut off value of 0.22mg/mg for protein creatinine ratio best predicted significant proteinuria with sensitivity, specificity, positive and negative predictive values of 87%, 92.6%, 90.6% and 89.3% respectively. Random urinary protein creatinine ratio is a simple inexpensive and excellent alternative to 24h urine collection. It's helpful in diagnosis of preeclampsia and can be used as a pre admission test in PIH cases.

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How to Cite
1.
Eslamian L, Behnam F, Foroohesh Tehrani Z, Jamal A, Marsoosi V. Random Urine Protein Creatinine Ratio as a Preadmission Test in Hypertensive Pregnancies with Urinary Protein Creatinine Ratio. Acta Med Iran. 49(2):81-84.
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