Hepatitis-C and Hepatitis-B Co-Infections in Patients with Human Immunodeficiency Virus in Tehran, Iran

  • SeyedAhmad SeyedAlinaghi Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Sara Jam Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Farhad Mehrkhani Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Fattahi Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran. AND Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Duman Sabzvari Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Kourorian Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran. AND Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Hossain Jabbari Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
  • Minoo Mohraz Mail Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
Hepatitis B virus, Hepatitis C virus, HIV, Seroepidemiologic studies

Abstract

We carried out a study to determine the seroprevalence of HBV and HCV infections in HIV positive patients at a main referral center for HIV/AIDS in Iran. Serum samples from 201 HIV positive patients referring to a referral center for HIV/AIDS were analyzed for the presence of some hepatitis B (HBsAg, anti-HBc, anti-HBs) and Hepatitis C (anti-HCV) markers, during 2004- 2005. HBsAg was positive in 27 patients (13.4%), anti-HBc was positive in 60 patients (29.8%) and anti-HBs in 23 patients (11.4%). Anti-HCV Ab was positive in 135 of 201 (67.2%). HBV and HCV coinfection was observed in 73 of 201 (36.3%). The maximum prevalence of HBV-HIV and HCV-HIV coinfections were seen in intravenous drug users; 61.2% and 85.1%, respectively (P<0.0001). The minimum prevalence of HBV-HIV and HCV-HIV were seen in HIV patients´wife (HIV+ patients who were infected by monogamous sexual contact with their HIV positive husband) both of them were 8% (P<0.0001). This study showed that HBV-HIV and HCV-HIV coinfections are significant in patients with HIV/AIDS in Iran. A greater relevance was observed in the association between HCV and HIV. This study suggests that it is necessary to investigate risk factors and risk groups for these infections in Iran.

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How to Cite
1.
SeyedAlinaghi S, Jam S, Mehrkhani F, Fattahi F, Sabzvari D, Kourorian Z, Jabbari H, Mohraz M. Hepatitis-C and Hepatitis-B Co-Infections in Patients with Human Immunodeficiency Virus in Tehran, Iran. Acta Med Iran. 49(4):252-257.
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