Peri-Implant Soft Tissue Management through Use of Cultured Gingival Graft: A Case Report
Tissue-engineered gingival graft was used for regenerating facial gingiva around an implant at lower left first premolar area with insufficient attached gingiva. Engineered gingival graft was produced by mixing 250 ml bovine skin collagen with 250 ml nutritional medium containing human gingival fibroblasts (2×105). 3 months post-surgery, there were gains in the attached gingiva compared to pre-surgery. The histological examination revealed a keratinized tissue on the treated site. Based on the result of this investigation, this graft was safe and capable of generating keratinized gingiva.
Horning GM, Mullen MP. Peri-implant free gingival grafts: rationale and technique. Compendium 1990;11(10):604, 606-10.
van Steenberghe D. Periodontal aspects of osseointegrated oral implants modum Brånemark. Dent Clin North Am 1988;32(2):355-70.
Block MS, Kent JN. Factors associated with soft- and hard-tissue compromise of endosseous implants. J Oral Maxillofac Surg 1990;48(11):1153-60.
Mitchell DL, Synnott SA, VanDercreek JA. Tissue reaction involving an intraoral skin graft and CP titaniummabutments: a clinical report. Int J Oral Maxillofac Implants 1990;5(1):79-84.
ten Bruggenkate CM, Krekeler G, van der Kwast WA, Oosterbeek HS. Palatal mucosa grafts for oral implant devices. Oral Surg Oral Med Oral Pathol 1991;72(2):154-8.
Moy PK, Weinlaender M, Kenney EB. Soft-tissue modifications of surgical techniques for placement and uncovering of osseointegrated implants. Dent Clin North Am 1989;33(4):665-81.
Pack AR, Gaudie WM, Jennings AM. Bony exostosis as a sequela to free gingival grafting: two case reports. J Periodontol 1991;62(4):269-71.
Silverstein L, Callan D. An acellular dermal matrix allograft and a palatal graft for tissue augmentation. Periodontal Insights 1996;6:3-6.
Baum BJ, Mooney DJ. The impact of tissue engineering on dentistry. J Am Dent Assoc 2000;131(3):309-18.
Wilson TG Jr, McGuire MK, Nunn ME. Evaluation of the safety and efficacy of periodontal applications of a living tissue-engineered human fibroblast-derived dermal substitute. II. Comparison to the subepithelial connective tissue graft: a randomized controlled feasibility study. J Periodontol 2005;76(6):881-9.
Okuda K, Momose M, Murata M, Saito Y, lnoie M, Shinohara C, Wolff LF, Yoshie H. Treatment of chronic= desquamative gingivitis using tissue-engineered human cultured gingival epithelial sheets: a case report. Int J Periodontics Restorative Dent 2004;24(2):119-25.
Pini Prato GP, Rotundo R, Magnani C, Soranzo C. Tissue engineering technology for gingival augmentation procedures: a case report. Int J Periodontics Restorative Dent 2000;20(6):552-9.
Prato GP, Rotundo R, Magnani C, Soranzo C, Muzzi L, Cairo F. An autologous cell hyaluronic acid graft technique for gingival augmentation: a case series. J Periodontol 2003;74(2):262-7.
Raghoebar GM, Tomson AM, Scholma J, Blaauw EH, Witjes MJ, Vissink A. Use of cultured mucosal grafts to cover defects caused by vestibuloplasty: an in vivo study. J Oral Maxillofac Surg 1995;53(8):872-8.
Ueda M, Hata KI, Sumi Y, Mizuno H, Niimi A. Periimplant soft tissue management through use of cultured mucosal epithelium. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86(4):393-400.
Vincent JW, Machen JB, Levin MP. Assessment of attached gingiva using the tension test and clinical measurements. J Periodontol 1976;47(7):412-4.
Fassake T, Morgenroth K. Comparative stomatoscopic and histochemical studies of the marginal gingiva in man. Parodontologie 1958;12:151-60.
Carranza FA, Carraro JJ. Effect of removal periosteum on post-operative results of mucogingival surgery. J Periodontol 1963;34:223-6.
Morrison M. Advances in the skin trade. Mechanical Eng 1999;121:40-3.
Parenteau N. The organogenesis story. Sci Am 1999; 280: 83-84.
Naughton G. The advanced tissue sciences story. Sci Am 1999; 280: 84-5.
Rheinwald JG, Green H. Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma.Cell 1975; 6: 317-30.
Karring T, Cumming BR, Oliver RC, Löe H. The origin of granulation tissue and its impact on postoperative results of mucogingival surgery. Journal of Periodontology 1975; 46: 577-85.
Copyright (c) Acta Medica Iranica
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.