Determination of Trace Elements in Patients with Chronic Hepatitis B
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Abstract
Chronic Hepatitis B virus (HBV) infection is a major liver disease worldwide and its clinical manifestations are linked to immune response. The purpose of this study was to evaluate the relationship between selenium, copper, and zinc in comparison with transaminase level in chronic HBV patients. Serum samples of the HBV infected patients were obtained from Tooba medical center, Sari, Iran. Sixty patients were enrolled in this study (36 men and 24 women), mean age: 39.6 ± 12.2 years. The concentration of zinc, selenium, copper and transaminases were determined using an autoanalyzer system. Concentrations of selenium (0.273 ±0.056 μg/dl) and zinc (2.1±0.037) was elevated in patients with low transaminase levels as were significantly different in comparison with patients with high transaminase level (P<0.05). Serum copper concentration was similar in two groups of patients. Elevated levels of transaminase concentrations were independently associated with low zinc and selenium concentrations in chronic HBV patients. It is concluded that serum zinc and selenium levels are associated with less hepatic damage in chronic HBV patients and might have a protective role during liver injury.
Das A, Maini MK. Innate and adaptive immune responses in hepatitis B virus infection. Dig Dis 2010;28(1):126-32.
Merican I, Guan R, Amarapuka D, Alexander MJ,Chutaputti A, Chien RN, Hasnian SS, Leung N, Lesmana L, Phiet PH, Sjalfoellah Noer HM, Sollano J, Sun HS, XuDZ. Chronic hepatitis B virus infection in Asian countries. J Gastroenterol Hepatol 2000;15(12):1356-61.
Darvesh AS, Bishayee A. Selenium in the prevention and treatment of hepatocellular carcinoma. Anticancer Agents Med Chem 2010;10(4):338-45.
Florescu L, Popa G, Bălănică G, Azoicăi D. Zinc--essentialmicronutrient for child health and nutrition. Rev Med Chir Soc Med Nat Iasi 2009;113(3):650-5.
Lim CE, Yii MF, Cheng NC, Kwan YK. The role of micronutrients in pregnancy. Aust Fam Physician 2009;38(12):980-4.
Iizaka S, Sanada H, Minematsu T, Oba M, Nakagami G, Koyanagi H, Nagase T, Konya C, Sugama J. Do nutritional markers in wound fluid reflect pressure ulcer status? Wound Repair Regen 2010;18(1):31-7.
Hegazy AA, Zaher MM, Abd El-Hafez MA, Morsy AA, Saleh RA. Relation between anemia and blood levels of lead, copper, zinc and iron among children. BMC ResNotes 2010;3:133.
Colić-Cvrlje V, Mise S. Monitoring patients with chronic hepatitis during and after therapy. Acta Med Croatica2009;63(5):377-83.
Lin CY, Ding HJ, Lin T, Lin CC, Kuo TH, Kao CH.Positive correlation between serum liver enzyme levels and standard uptake values of liver on FDG-PET. ClinImaging 2010;34(2):109-12.
Sellier P, Schnepf N, Jarrin I, Mazeron MC, Simoneau G,Parrinello M, Evans J, Lafuente-Lafuente C. Description ofliver disease in a cohort of HIV/HBV coinfected patients. J Clin Virol 2010;47(1):13-7.
Mocchegiani E, Malavolta M. Zinc-gene interactionrelated to inflammatory/immune response in ageing. Genes Nutr 2008;3(2):61-75.
Wu M, Kang MM, Schoene NW, Cheng WH. Seleniumcompounds activate early barriers of tumorigenesis. J Biol Chem 2010;285(16):12055-62.
Reddy KP, Sailaja G, Krishnaiah C. Protective effects of selenium on fluoride induced alterations in certainenzymes in brain of mice. J Environ Biol 2009;30(5 Suppl):859-64.
Saghir M, Shaheen N, Shah MH. Comparative evaluation of trace metals in the blood of hepatitis C patients and healthy donors. Biol Trace Elem Res 2011;143(2):751-63.
Gomez EV, Perez YM, Sanchez HV, Forment GR, Soler EA, Bertot LC, Garcia AY, del Rosario Abreu Vazquez M, Fabian LG. Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C. World J Gastroenterol 2010;16(21):2638-47.
| Files | ||
| Issue | Vol 49, No 10 (2011) | |
| Section | Articles | |
| Keywords | ||
| Zinc Selenium Hepatitis B Copper | ||
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