Effect of Elective Percutaneous Coronary Intervention on Left Ventricular Function in Patients with Coronary Artery Disease

  • Younes Nozari Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Nader Jangi Oskouei Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Khazaeipour Mail Research Deputy of Imam Khomeini Hospital Complex, Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
PCI (Percutaneous Coronary Intervention), CABG (Coronary Artery Bypass Graft), CAD (Coronary Artery Disease), EF (Ejection Fraction), LV diastolic function

Abstract

Coronary artery disease is one of the most common causes of mortality and morbidity across the world. Its treatment includes medical treatment, coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI). The purpose of this study was to investigate the effect of PCI on echocardiographic findings of left ventricular (LV) systolic and diastolic function. 115 patients with coronary artery disease candidate for PCI were enrolled to our study. Echocardiography was done before PCI, the day after and 3-6 months later. LV systolic and diastolic function were measured and recorded. Echocardiographic finding compared with repeated measurement analysis. Mean age of the patients was 57.8±8.38 years. The mean Ejection Fraction (EF) was (%40.52±6.36) before, (%41.83±7.14) the day after, and (%44.0±7.89) 3-6 months after PCI. Diastolic dysfunction were mild to moderate before PCI, which in %74 (86 patients) were improved to mild dysfunction the day after PCI but not changed 3-6 months later (P<0.0001). PCI improved LV ejection fraction, and LV diastolic function in our patient’s population.

References

Gaziano JM, Manson JE, Ridker PM. Primary and secondary prevention of coronary heart disease. In: Libby P, Bonow RO, Mann DL, Zipes DP, editors.Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed.St. Louis, Mo: WB Saunders; 2007. p. 1119-45.

Hiatt WR, Cooke JP. Atherogenesis and the medical management of atherosclerosis. In: RutherfordRB, editor. Vascular Surgery. 5th ed.Philadelphia, PA: WBSaunders Co.; 2000. Vol. 1. p. 333-46.

Okrainec K, Banerjee DK, Eisenberg MJ.Coronary artery disease in the developing world. Am Heart J 2004;148(1):7-15.

Banerjee P, Card D.Preserving left ventricular function during percutaneous coronary intervention. J Invasive Cardiol 2007;19(10):440-3.

Rihal CS, Raco DL, Gersh BJ, Yusuf S.Indications for coronary artery bypass surgery and percutaneous coronary intervention in chronic stable angina: review of the evidence and methodological considerations. Circulation 2003;108(20):2439-45.

Phillips HR, O'Connor CM, Rogers J.Revascularization for heart failure. Am Heart J 2007;153(4 Suppl):65-73.

Silva JC, Rochitte CE, Júnior JS, Tsutsui J, Andrade J, Martinez EE, Moffa PJ, Menegheti JC, Kalil-Filho R,Ramires JF, Nicolau JC.Late coronary artery recanalization effects on left ventricular remodelling and contractility by magnetic resonance imaging. Eur Heart J 2005;26(1):36-43.

Lane GE, Holmes DR Jr. Primary percutaneous coronary intervention in the management of acute myocardialinfarction. In: Libby P, Bonow RO, Mann DL, Zipes DP, editors.Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. St. Louis, Mo: WB Saunders; 2007. p.1301-11.

Connolly HM, Oh JK. Echocardiography. In: Libby P, Bonow RO, Mann DL, Zipes DP, editors.Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. St. Louis, Mo: WB Saunders; 2007. p.227-326.

Buszman P, Szkróbka I, Gruszka A, Parma R, Tendera Z, Leśko B, Wilczyński M, Bochenek T, Wojakowski W, Bochenek A, Tendera M.Comparison of effectiveness of coronary artery bypass grafting versus percutaneous coronary intervention in patients with ischemic cardiomyopathy. Am J Cardiol 2007;99(1):36-41.

Nechvatal L, Hlinomaz O, Groch L, Hornacek I, Sitar J, Orban M, Petrikovits E.Serial echocardiographic assessment of the left ventricular function after direct PCI. Kardiol Pol 2003;59(11):397-401.

Ioannidis JP, Katritsis DG.Percutaneous coronary intervention for late reperfusion after myocardial infarction in stable patients. Am Heart J 2007;154(6):1065-71.

Remmelink M, Sjauw KD, Henriques JP, Vis MM, van der Schaaf RJ, Koch KT, Tijssen JG, de Winter RJ, Piek JJ, Baan J Jr.Acute left ventricular dynamic effects of primary percutaneous coronary intervention from occlusion to reperfusion. J Am Coll Cardiol 2009;53(17):1498-502.

Agirbasli M, Guler N.Recovery of left ventricular systolic function after left anterior descending coronary artery stenting. J Interv Cardiol 2005;18(2):83-8.

Banerjee P, Banerjee T, Khand A, Clark AL, Cleland JG.Diastolic heart failure: neglected or misdiagnosed? J Am Coll Cardiol 2002;39(1):138-41.

Carluccio E, Biagioli P, Alunni G, Murrone A, Leonelli V, Pantano P, Vincenti G, Giombolini C, Ragni T, Reboldi G, Gentile F, Ambrosio G.Effect of revascularizing viable myocardium on left ventricular diastolic function in patients with ischaemic cardiomyopathy. Eur Heart J 2009;30(12):1501-9.

Tanaka H, Kawai H, Tatsumi K, Kataoka T, Onishi T, Nose T, Mizoguchi T, Yokoyama M.Improved regional myocardial diastolic function assessed by strain rate imaging in patients with coronary artery disease undergoing percutaneous coronary intervention. J Am Soc Echocardiogr 2006;19(6):756-62.

Shewan LG, Coats AJ. Ethics in the authorship and publishing of scientific articles. Int J Cardiol 2010;144:1-2.

How to Cite
1.
Nozari Y, Jangi Oskouei N, Khazaeipour Z. Effect of Elective Percutaneous Coronary Intervention on Left Ventricular Function in Patients with Coronary Artery Disease. Acta Med Iran. 50(1):26-30.
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