Helicobacter pylori in Diabetic and Non-Diabetic Patients with Dyspepsia
,
Abstract
Helicobacter pylori (H. pylori) is one of the most common chronic infections in patients with gastrointestinal disorders. Recent reports suggested that H. pylori might have high prevalence among patients with diabetes. The aim of this cross-sectional study was to assess the prevalence of H. pylori infection in diabetes mellitus and to study the relationship between histological findings and H. pylori infection in diabetic patients. Eighty patients with dyspepsia that were referred to our gastrointestinal department between May 2007 and May 2008 were included in our study. We checked fasting blood sugar for all of the study samples. All of patients underwent upper endoscopy and biopsy specimens were obtained from the antrum and the corpus. The specimens for the presence of H. pylori were colored by Giemsa stains. A single pathologist evaluated the histology slides. We found that prevalence of H. pylori infection was significantly higher in diabetics than in non-diabetics (P=0.001). Indeed, the prevalence of gastritis did differ significantly between the two groups (P=0.001). According to our results diabetes mellitus is one of the risk factor that must be considered in evaluation of H. pylori infection in diabetic patients with dyspepsia.
Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 1989;96(2 Pt 2 Suppl):615-25.
Forman D, Newell DG, Fullerton F, Yarnell JW, Stacey AR, Wald N, Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ 1991;302(6788):1302-5.
Parsonnet J, Hansen S, Rodriguez L, Gelb AB, WarnkeRA, Jellum E, Orentreich N, Vogelman JH, Friedman GD. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994;330(18):1267-71.
Oldenburg B, Diepersloot RJ, Hoekstra JB. High seroprevalence of Helicobacter pylori in diabetes mellitus patients. Dig Dis Sci 1996;41(3):458-61.
Perdichizzi G, Bottari M, Pallio S, Fera MT, Carbone M, Barresi G. Gastric infection by Helicobacter pylori and antral gastritis in hyperglycemic obese and in diabetic subjects. New Microbiol 1996;19(2):149-54.
Kojecký V, Roubalík J, Bartoníková N. Helicobacter pylori in patients with diabetes mellitus. Vnitr Lek 1993;39(6):581-4.
Schvarcz E, Palmér M, Ingberg CM, Aman J, Berne C. Increased prevalence of upper gastrointestinal symptoms in long-term type 1 diabetes mellitus. Diabet Med 1996;13(5):478-81.
Spångéus A, El-Salhy M, Suhr O, Eriksson J, Lithner F.Prevalence of gastrointestinal symptoms in young and middle-aged diabetic patients. Scand J Gastroenterol 1999;34(12):1196-202.
Ko GT, Chan WB, Chan JC, Tsang LW, Cockram CS. Gastrointestinal symptoms in Chinese patients with Type 2 diabetes mellitus. Diabet Med 1999;16(8):670-4.
Clouse RE, Lustman PJ. Gastrointestinal symptoms in diabetic patients: lack of association with neuropathy. Am J Gastroenterol 1989;84(8):868-72.
Lluch I, Ascaso JF, Mora F, Minguez M, Peña A, Hernandez A, Benages A. Gastroesophageal reflux in diabetes mellitus. Am J Gastroenterol 1999;94(4):919-24.
Rathmann W, Enck P, Frieling T, Gries FA. Visceral afferent neuropathy in diabetic gastroparesis. Diabetes Care 1991;14(11):1086-9.
Annese V, Bassotti G, Caruso N, De Cosmo S, Gabbrielli A, Modoni S, Frusciante V, Andriulli A. Gastrointestinal motor dysfunction, symptoms, and neuropathy in noninsulin-dependent (type 2) diabetes mellitus. J Clin Gastroenterol 1999;29(2):171-7.
Jones KL, Horowitz M, Berry M, Wishart JM, Guha S. Blood glucose concentration influences postprandial fullness in IDDM. Diabetes Care 1997;20(7):1141-6.
Talley NJ, Young L, Bytzer P, Hammer J, Leemon M,Jones M, Horowitz M. Impact of chronic gastrointestinalsymptoms in diabetes mellitus on health-related quality of life. Am J Gastroenterol 2001;96(1):71-6.
Simon L, Tornóczky J, Tóth M, Jámbor M, Sudár Z. The significance of Campylobacter pylori infection in gastroenterologic and diabetic practice. Orv Hetil 1989;130(25):1325-9.
Gasbarrini A, Ojetti V, Pitocco D, Franceschi F, Candelli M, Torre ES, Gabrielli M, Cammarota G, Armuzzi A, Pola R, Pola P, Ghirlanda G, Gasbarrini G. Insulin-dependent diabetes mellitus affects eradication rate of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 1999;11(7):713-6.
Gasbarrini A, Ojetti V, Pitocco D, Armuzzi A, Silveri NG,Pola P, Ghirlanda G, Gasbarrini G. Efficacy of different Helicobacter pylori eradication regimens in patients affected by insulin-dependent diabetes mellitus. Scand J Gastroenterol 2000;35(3):260-3.
Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut 1999;45 Suppl 2:II37-42.
Report of the Expert Committee on the Diagnosis and Treatment of Diabetes Mellitus. Diabetes Care 1997;20(7):1183-97.
Ricci JA, Siddique R, Stewart WF, Sandler RS, Sloan S,Farup CE. Upper gastrointestinal symptoms in a U.S. national sample of adults with diabetes. Scand J Gastroenterol 2000;35(2):152-9.
Bener A, Micallef R, Afifi M, Derbala M, Al-Mulla HM, Usmani MA. Association between type 2 diabetes mellitus and Helicobacter pylori infection. Turk J Gastroenterol 2007;18(4):225-9.
Gentile S, Turco S, Oliviero B, Torella R. The role of autonomic neuropathy as a risk factor of Helicobacter pylori infection in dyspeptic patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 1998;42(1):41-8.
Marrollo M, Latella G, Melideo D, Storelli E, Iannarelli R, Stornelli P, Valenti M, Caprilli R. Increased prevalence of Helicobacter pylori in patients with diabetes mellitus. Dig Liver Dis 2001;33(1):21-9.
Agrawal RP, Sharma R, Garg D, Pokharna R, Kochar DK, Kothari RP. Role of Helicobacter pylori in causation ofdiabetic gastropathies and non-gastrointestinal complications in type 2 diabetes. J Indian Med Assoc 2010;108(3):140-3.
Devrajani BR, Shah SZ, Soomro AA, Devrajani T. Type 2 diabetes mellitus: A risk factor for Helicobacter pyloriinfection: A hospital based case-control study. Int J Diabetes Dev Ctries 2010;30(1):22-6.
Gasbarrini A, Ojetti V, Pitocco D, De Luca A, Franceschi F, Candelli M, Sanz Torre E, Pola P, Ghirlanda G, Gasbarrini G. Helicobacter pylori infection in patients affected by insulin-dependent diabetes mellitus. Eur J Gastroenterol Hepatol 1998;10(6):469-72.
Małlecki M, Bień AI, Galicka-Latałla D, Stachura J, Sieradzki J. The prevalence of Helicobacter pylori infection and types of gastritis in diabetic patients. The Kraków Study. Exp Clin Endocrinol Diabetes 1996;104(5):365-9.
Xia HH, Talley NJ, Kam EP, Young LJ, Hammer J, Horowitz M. Helicobacter pylori infection is not associatedwith diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus. Am J Gastroenterol 2001;96(4):1039-46.
Anastasios R, Goritsas C, Papamihail C, Trigidou R, Garzonis P, Ferti A. Helicobacter pylori infection in diabetic patients: prevalence and endoscopic findings. Eur J Intern Med 2002;13(6):376.
Demir M, Gokturk HS, Ozturk NA, Kulaksizoglu M, SerinE, Yilmaz U. Helicobacter pylori prevalence in diabetes mellitus patients with dyspeptic symptoms and its relationship to glycemic control and late complications. Dig Dis Sci 2008;53(10):2646-9.
Türkay C, Erbayrak M, Bavbek N, Yenıdünya S, Eraslan E, Kasapoğlu B. Helicobacter pylori and histopathological findings in patients with dyspepsia. Turk J Gastroenterol 2011;22(2):122-7.
Nguyen TL, Uchida T, Tsukamoto Y, Trinh DT, Ta L, Mai BH, Le SH, Thai KD, Ho DD, Hoang HH, Matsuhisa T, Okimoto T, Kodama M, Murakami K, Fujioka T, Yamaoka Y, Moriyama M. Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study. BMC Gastroenterol 2010;10:114.
| Files | ||
| Issue | Vol 50, No 5 (2012) | |
| Section | Articles | |
| Keywords | ||
| Gastrointestinal disorders Dyspepsia Helicobacter pylori infection Diabetes | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
