Seroprevalence of Cytomegalovirus in Patients with and without Coronary Artery Diseases at Madani Heart Center, Iran
,
Abstract
Inflammation plays a major role in coronary artery disease (CAD). Currently, it is unclear, whether Cytomegalovirus (CMV) infection is associated with the risk of the atherosclerosis. The aim of this study was to determine the prevalence of anti- CMV antibodies in CAD and non CAD patients undergoing artery bypass surgery. Sera from 157 patients who underwent coronary angiography were tested for CMV by enzyme linked immunosorbent assay (ELISA) at Madani Heart Hospital, Tabriz University of Medical Sciences, Iran. Our study population was 58.6% male and 41.4% female, with an age range of 38 to 86 years. The prevalence of CMV positivity tended to be higher in coronary artery diseases patients than in those without non coronary artery diseases (83.2% versus 63.6%) (P= 0.01). This analysis demonstrated that CMV seropositivity may be a risk factor for CAD in the present study population.
Corrado E, Novo S. Role of inflammation and infection in vascular disease. Acta Chir Belg 2005;105(6):567-79.
Mendis S, Abegunde D, Yusuf S, Ebrahim S, Shaper G, Ghannem H, et al. WHO study on Prevention of REcurrences of Myocardial Infarction and StrokE (WHOPREMISE). Bull World Health Organ 2005;83(11):820-9.
Tong DY, Wang XH, Xu CF, Yang YZ, Xiong SD. Hepatitis B virus infection and coronary atherosclerosis: results from a population with relatively high prevalence of hepatitis B virus. World J Gastroenterol 2005;11(9):1292-6.
Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340(2):115-26.
Shah PK. Link between infection and atherosclerosis: whoare the culprits: viruses, bacteria, both, or neither? Circulation 2001;103(1):5-6.
Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet 1997;350(9075):430-6.
Fabricant CG, Fabricant J, Litrenta MM, Minick CR. Virusinduced atherosclerosis. J Exp Med 1978;148(1):335-40.
Ibrahim AI, Obeid MT, Jouma MJ, Moasis GA, Al-Richane WL, Kindermann I, et al. Detection of herpes simplex virus, cytomegalovirus and Epstein-Barr virus DNA in atherosclerotic plaques and in unaffected bypass grafts. J Clin Virol 2005;32(1):29-32.
Kiechl S, Egger G, Mayr M, Wiedermann CJ, Bonora E, Oberhollenzer F, et al. Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study. Circulation 2001;103(8):1064-70.
Ridker PM, Hennekens CH, Stampfer MJ, Wang F. Prospective study of herpes simplex virus, cytomegalovirus, and the risk of future myocardial infarction and stroke. Circulation 1998;98(25):2796-9.
Zhu J, Quyyumi AA, Norman JE, Csako G, Epstein SE. Cytomegalovirus in the pathogenesis of atherosclerosis: the role of inflammation as reflected by elevated Creactive protein levels. J Am Coll Cardiol 1999;34(6):1738-43.
Zhou YF, Leon MB, Waclawiw MA, Popma JJ, Yu ZX, Finkel T, et al. Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy. N Engl J Med 1996;335(9):624-30.
Espinola-Klein C, Rupprecht HJ, Blankenberg S, Bickel C,Kopp H, Victor A, et al. Impact of infectious burden on progression of carotid atherosclerosis. Stroke 2002;33(11):2581-6.
Tomiyama H, Arai T, Hirose K, Hori S, Yamamoto Y, Yamashina A. Hepatitis C virus seropositivity, but not hepatitis B virus carrier or seropositivity, associated with increased pulse wave velocity. Atherosclerosis 2003;166(2):401-3.
Blum A, Giladi M, Weinberg M, Kaplan G, Pasternack H, Laniado S, et al. High anti-cytomegalovirus (CMV) IgG antibody titer is associated with coronary artery disease and may predict post-coronary balloon angioplasty restenosis. Am J Cardiol 1998;81(7):866-8.
Espinola-Klein C, Rupprecht HJ, Blankenberg S, Bickel C, Kopp H, Rippin G, et al. Are morphological or functional changes in the carotid artery wall associated with Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, or herpes simplex virus infection? Stroke 2000;31(9):2127-33.
Muhlestein JB, Horne BD, Carlquist JF, Madsen TE, Bair TL, Pearson RR, et al. Cytomegalovirus seropositivity and C-reactive protein have independent and combined predictive value for mortality in patients with angiographically demonstrated coronary artery disease. Circulation 2000;102(16):1917-23.
Roivainen M, Viik-Kajander M, Palosuo T, Toivanen P, Leinonen M, Saikku P, et al. Infections, inflammation, and the risk of coronary heart disease. Circulation 2000;101(3):252-7.
Abgueguen P, Delbos V, Chennebault JM, Payan C, Pichard E. Vascular thrombosis and acute cytomegalovirus infection in immunocompetent patients: report of 2 cases and literature review. Clin Infect Dis 2003;36(11):E134-9.
Stöllberger C, Mölzer G, Finsterer J. Seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis. Clin Diagn Lab Immunol 2001;8(5):997-1002.
Eryol NK, Kiliç H, Gül A, Ozdogru I, Inanç T, Dogan A,et al. Are the high levels of cytomegalovirus antibodies a determinant in the development of coronary artery disease? Int Heart J 2005;46(2):205-9.
Choussat R, Montalescot G, Collet J, Jardel C, Ankri A, Fillet A, et al. Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-Q-wave acute myocardial infarction. Am J Cardiol 2000;86(4):379-84.
Fagerberg B, Gnarpe J, Gnarpe H, Agewall S, Wikstrand J. Chlamydia pneumoniae but not cytomegalovirus antibodies are associated with future risk of stroke and cardiovascular disease: a prospective study in middle-aged to elderly men with treated hypertension. Stroke 1999;30(2):299-305.
Hoffmeister A, Rothenbacher D, Bode G, Persson K, März W, Nauck MA, et al. Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile. Arterioscler Thromb Vasc Biol 2001;21(3):427-32.
Mayr M, Kiechl S, Willeit J, Wick G, Xu Q. Infections, immunity, and atherosclerosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis. Circulation 2000;102(8):833-9.
Tiran A, Tio RA, Oostenveld E, Harmsen MC, Tiran B, Den Heijer P, et al. Humoral immune response to human cytomegalovirus in patients undergoing percutaneous transluminal coronary angioplasty. Clin Diagn Lab Immunol 1999;6(1):45-9.
| Files | ||
| Issue | Vol 48, No 6 (2010) | |
| Section | Articles | |
| Keywords | ||
| Coronary artery diseases cytomegalovirus infection | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
