Evaluation of the Effect of Low Level Laser on Prevention of Chemotherapy-Induced Mucositis
Radiotherapy in the head and neck region and chemotherapy might give rise to oral mucositis which is a severe and painful inflammation. There is no known definite cure for mucositis. A number of studies have attempted to evaluate the effect of low-power laser on radiotherapy- and chemotherapy-induced mucositis. The present study was undertaken to evaluate the effect of low-power laser on the prevention of mucositis, xerostomia and pain as a result of chemotherapy. The subjects in this double-blind randomized controlled study were 24 adult patients who underwent chemotherapy during 2009-2010. The results showed that low-power laser was able to decrease the effect of chemotherapy on oral mucositis, xerostomia and pain in a variety of malignancies (P<0.05). It can be concluded that low-power laser might decrease the intensity of mucositis.
Arbabi-kalati F, Arbabi-kalati F, Deghatipour M, Ansari Moghadam A. Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind randomized clinical trial. Arch Iran Med. 2012 15(7):413-7.
Lin LC, Que J, Lin LK, Lin FC. Zinc. supplementation to improve mucositis in patients after radiotherapy for head and neck cancers: a double-blind ,randomized study. Int J Radiat Oncol Biol Phys 2006;65(3):745-50.
Epstein JB, Schubert MM. Managing pain in mucositis .Semin Oncol Nurs 2004;20(1):30-7.
Nyman J, Turesson I. Does the interval between fractions matter in the range of 4–8 h in radiotherapy? A study of acute and late human skin reactions.Radiother Oncol 1995;34(3):171-8.
Mantovani G, Macciò A, Bianchi A, Curreli L, Ghiani M, Santona MC, Del Giacco GS. Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy. Int J Clin Lab Res 1995;25(3):135-41.
Amy P, David C, Gerald G, Deborah D, Susan Y .Mucositis in Head and Neck Cancer:Economic and Quality-of-Life Outcomes. J Natl Cancer Inst Monogr 2001;29:45–51.
Klastersky J, Aoun M. Opportunistic infections in patients with cancer. Ann Oncol .2004;15( 4):329–35.
Dodd MJ, Larson PJ, Dibble SL, Miaskowski C, Greenspan D, MacPhail L, Hauck WW, Paul SM, Ignoffo R, Shiba G. Randomized clinical trial of chlorhexidine versus laser off for prevention of oral mucositis in patients receiving chemotherapy. Oncol Nurs forum 1996;23(6):921-7.
William C, Lawrence S. E.Management of oral mucositis during local radiation and systemic chemotherapy: A study of 98 patients.J Prosthet Dent 199166(3):361-9
Vokurka S, Bystrická E, Koza V, Scudlová J, Pavlicová V, Valentová D, Bocková J, Misaniová L. The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after highdose chemotherapy and APBSCT—results of a randomized multicentre study. Support Care Cancer 2005;13(7):554-8.
Gerry B, Loretta L, Paul Cuddy P, Bruce B .The effects of sucralfate suspension and diphenhydramine syrup plus kaolin-pectin on radiotherapy-induced mucositis.Oral Surg Oral Med Oral Pathol 1991;71(3):288-93.
Meredith R, Salter M, Kim R, Spencer S, Weppelmann B, Rodu B, Smith J, Lee J. Sucralfate for radiation mucositis: Results of a double-blind randomized trial 1997;37(2):275-9.
Martins MD, Marques MM, Bussadori SK, Martins MA, Pavesi VC, Mesquita-Ferrari RA, Fernandes KP. Comparative analysis between Chamomilla recutita and corticosteroids on wound healing. An in vitro and in vivo study. Phytother Res 2009:23(2):274–8.
Turhal N. S, Erdal S, Karacay S. Efficacy of treatment to relieve mucositis-induced discomfort. Support Care Cancer 2000;8(1):55-8.
Arun Maiya G, Sagar MS, Fernandes D. Effect of low level helium-neon(He-Ne) laser therapy in the prevention & treatment of radiation induced mucositis in head and neck cancer patients. Indian Journal of medical research 2006;124(4):399-402.
Genot Marie-Therese, Klastersky J. low-level laser for prevention and therapy of oral mucositis induced by chemotherapy or radiotherapy. Current opinion in Oncology 2005;17(3):236-40.
Lalla RV, Sonis ST, Peterson DE. Management of Oral Mucositis in Patients with Cancer. Dent Clin North Am 2008;52(1):61–77.
Ciais G, Namer M, Schneider M, Demard F, Pourreau- Schneider N, Martin PM, Soudry M, Franquin JC, Zattara H. La laserothérapie dans la prévention et le traitement des mucositis liées a la chimiothérapie anticancerous.Bull Cancer 1992;79(2):183-91.
Bensadoun RJ, Franquin JC, Ciais G, Darcourt V, Schubert MM, Viot M, Dejou J, Tardieu C, Benezery K, Nguyen TD, Laudoyer Y,Dassonville O, Poissonnet G, Vallicioni J, Thyss A, Hamdi M, Chauvel P, Demard F. Low-energy He/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancer.Support Care Cancer 1999;7(4):244-52.
Cowen D, Tardieu C, Schubert M, Peterson D, Resbeut M, Faucher C, Franquin JC. Low energy helium-neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant:results of a double blind randomizedtrial.Int J Radiat Oncol Boil Phys 1997;38(4):697-703.
Wong SF, Wilder-Smith P. Pilot Study of Laser Effects on Oral Mucositis in Patients Receiving Chemotherapy. TheCancer Journal 2002;8(3):247-54.
Sandoval RL, Koga DH, Buloto LS, Suzuki R, Dib LL. management of Chemo and radiotherapy induced oral mucositis with low energy laser: initial results of A.C.Camargo Hospital. J Appl Oral Sci 2003;11(4):337-41.
Nes AG, Posso MB.Patients with moderate chemotherapyinduced mucositis: pain therapy using low intensity lasers. Int Nurs Rev 2005;52(1):68-72.
Antunes HS, de Azevedo AM, da Silva Bouzas LF, Adão CA, Pinheiro CT, Mayhe R, et al. Low-power laser in theprevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial. Blood. 2007;109(5):2250-5.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.