Bipolar Disorder in Women with Polycystic Ovarian Syndrome (PCO)
This study was designed to determine the prevalence of bipolar disorder in women with polycystic ovarian syndrome (PCO). One hundred and ten women with definite diagnosis of PCO and one hundred and ten age-matched infertile women due to other reasons except for PCO were enrolled in this case-control study. Ten ml fasting venous blood sample obtained to measure fasting glucose, LH and FSH. Height, weight and waist-to-hip ratio (WHR) were also recorded by an expert technician. A psychiatrist examined all 220 cases in order to determine the prevalence of depression and bipolarity. Mean age of each group participants were not significantly different while FBS, LH and LH/FSH levels were significantly higher in PCO patients. Eighty eight case were depressed in PCO group while 96 were depressed in control group (P=0.03). Bipolar disorder were higher in PCO group in comparison with controls (8 vs. 0, P=0.004). Psychiatric disorders should be considered in PCO women.
Venkatesan AM, Dunaif A, Corbould A. Insulin resistance in polycystic ovary syndrome:progress and paradoxes. Recent Prog Horm Res 2001;56(6):295-308.
Hahn S, Bering van Halteren W, Kimmig R, et al. Diagnostic procedures in polycystic ovary syndrome. J Lab Med 2003;27(1/2):53-9.
Azziz R, Woods KS, Reyna R, et al. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89(6):2745-9.
Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005;352(12):1223-36.
Eggers S, Kirchengast S. The polycystic ovary syndrome—a medical condition but also an important psychosocial problem. Coll Anthropol 2001;25(2):673-85.
Hahn S, Janssen OE, Tan S, et al. Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome. Eur J Endocrinol 2005;153(6):853-60.
Elsenbruch S, Hahn S, Kowalsky D, et al. Quality of life, psychosocial well-being, and sexual satisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003;88(12):5801-7.
Coffey S, Bano G, Mason HD. Health-related quality of life in women with polycystic ovary syndrome:a comparison with the general population using the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and the Short Form-36 (SF-36). Gynecol Endocrinol 2006;22(2):80-6.
Klipstein KG, Goldberg JF. Screening for bipolar disorder in women with polycystic ovary syndrome:A pilot study. J Affect Disord 2006;91(2-3):205-9.
Judd LL, Akiskal HS. The prevalence and disability of bipolar spectrum disorders in the US population:reanalysis of the ECA database taking into account subthreshold cases. J Affect Disord 2003;73(1-2):123-31.
Perron BE, Howard MO, Nienhuis JK, et al. Prevalence and burden of general medical conditions among adults with bipolar I disorder:results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 2009;70(10):1407-15.
Regenold WT, Thapar RK, Marano C, et al. Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug use. J Affect Disord 2002;70(1):19-26.
O'Donovan C, Kusumakar V, Graves G, et al. Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder. J Clin Psychiatry 2002;63(4):322-30.
McIntyre RS, Mancini DA, McCann S, et al. Valproate, bipolar disorder and polycystic ovarian syndrome. Bipolar Disord 2003;5(1):28-35.
Rasgon NL, Altshuler LL, Gudeman D, et al. Medication status and polycystic ovary syndrome in women with bipolar disorder:a preliminary report. J Clin Psychiatry 2000:61(3):173-8.
Rassi A, Veras AB, dos Reis M, et al. Prevalence of psychiatric disorders in patients with polycystic ovary syndrome. Compr Psychiatry 2010;51(6):599-602.
Kenna HA, Jiang B, Rasgol NL. Reproductive and Metabolic Abnormalities Associated with Bipolar Disorder and Its Treatment. Harv Rev Psychiatry 2009;17(2):138-46.
Isojärvi JI, Laatkainen TJ, Pakarinen AJ, et al. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med 1993;329(19):1383-8.
Joffe H, Cohen LS, Suppes T, et al. Valproate is associated with newonset oligoamenorrhea with hyperandrogenism in women with bipolar disorder. Biol Psychiatry 2006;59(11):1078-86.
Rasgon NL, Rao RC, Hwang S, et al. Depression in women with polycystic ovary syndrome:clinical and biochemical correlates. J Affect Disord 2003;74 (3):299-304.
Nemeroff C.B. Clinical significance of psychoneuroendocrinology in psychiatry:focus on the thyroid and adrenal. J Clin Psychiatry 1989;50 (suppl):13-20.
Copyright (c) Acta Medica Iranica
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.