Association between Iron Deficiency Anemia and Helicobacter Pylori Infection among Children Under Six Years in Iran
,
Abstract
This study was conducted to evaluate the association between H. pylori infection and Iron deficiency anemia (IDA) among preschool children (age range: 40-75 months) at a tertiary referral hospital in Tehran.In a case-control study, the prevalence of H. pylori seropositivity was compared between 64 children with IDA diagnosis and 70 healthy non-anemic sex- and age-matched controls. Totally, 52 (81.3%) children with IDA and 10 (14.3%) non-anemic controls had a positive antibody level for H. pylori specific IgG and the difference between two groups was statistically significant (P<0.0001). H. pylori infection had a significant high prevalence among preschool patients with IDA. Eradication of H. pylori infection is recommended for patients with refractory IDA.
Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.nLancet 1984;1(8390):1311-5.
Kandulski A, Selgrad M, Malfertheiner P. Helicobacter pylori infection: a clinical overview. Dig Liver Dis 2008;40(8):619-26.
Webb PM, Knight T, Greaves S, et al. Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for a person to person transmission in early life. BMJ 1994;308(6931):750-3.
Nouraie M, Latifi-Navid S, Rezvan H, et al. Childhood hygienic practice and family education status determine the prevalence of Helicobacter pylori infection in Iran. Helicobacter 2009;14(1):40-6.
Massarrat S, Saberi-Firoozi M, Soleimani A, et al. Peptic ulcer disease, irritable bowel syndrome and constipation in two populations in Iran. Eur J Gastroenterol Hepatol 1995;7(5):427-33.
Malekzadeh R, Sotoudeh M, Derakhshan MH, et al. Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran. J Clin Pathol 2004;57(1):37-42.
Tan HJ, Goh KL. Extragastrointestinal manifestations of Helicobacter pylori infection: facts or myth? A critical review. J Dig Dis 2012;13(7):342-9.
Lutter CK. Iron deficiency in young children in lowincome countries and new approaches for its prevention. J Nutr 2008;138(12):2523-8.
Huang X, Qu X, Yan W, et al. Iron deficiency anaemia can be improved after eradication of Helicobacter pylori. Postgrad Med J 2010;86(1015):272-8.
Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol 2006;13(3):158-65.
Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 2001;131(2S-2):649S-66S; discussion 66S-68S.
Kadivar MR, Yarmohammadi H, Mirahmadizadeh AR, et al. Prevalence of iron deficiency anemia in 6 months to 5 years old children in Fars, Southern Iran. Med Sci Monit 2003;9(2):CR100-4.
Keikhaei B, Zandian K, Ghasemi A, et al. Iron-deficiency anemia among children in southwest Iran. Food Nutr Bull 2007;28(4):406-11.
Pacifico L, Anania C, Osborn JF, et al. Consequences of Helicobacter pylori infection in children. World J Gastroenterol 2010;16(41):5181-94.
Dufour C, Brisigotti M, Fabretti G, et al. Helicobacter pylori gastric infection and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1993;17(2):225-7.
Zamani A, Shariat M, Oloomi Yazdi Z, et al. Relationship between Helicobacter pylori infection and serum ferritin level in primary school children in Tehran-Iran. Acta Med Iran 2011;49(5):314-8.
Haghi-Ashtiani MT, Monajemzadeh M, Motamed F, et al. Anemia in children with and without Helicobacter pyloriinfection. Arch Med Res 2008;39(5):536-40.
Hoseinzadeh M, Khosravi A, Sayemiri K, et al. The antibody titers to Helicobacter pylori in 7 - 12 year old iron deficiency anemic children, in Ilam. J Res Med Sci 2010;15(6):324-30.
Qu XH, Huang XL, Xiong P, et al. Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis. World J Gastroenterol 2010;16(7):886-96.
Muhsen K, Cohen D. Helicobacter pylori infection and iron stores: a systematic review and meta-analysis. Helicobacter 2008;13(5):323-40.
Lee JH, Choe YH, Choi YO. The expression of ironrepressible outer membrane proteins in Helicobacter pylori and its association with iron deficiency anemia. Helicobacter 2009;14(1):36-9.
Baysoy G, Ertem D, Ademoglu E, et al. Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 2004;38(2):146-51.
Zhang ZF, Yang N, Zhao G, et al. Effect of Helicobacter pylori eradication on iron deficiency. Chin Med J (Engl) 2010;123(14):1924-30.
Yuan W, Li Y, Yang K, et al. Iron deficiency anemia in Helicobacter pylori infection: meta-analysis of randomized controlled trials. Scand J Gastroenterol 2010;45(6):665-76.
Banerjee S, Bishop W. Effect of Helicobacter pylori infection on gastric acid secretion and iron absorption: can we iron out the issue? J Pediatr Gastroenterol Nutr 2005;40(1):102-3.
| Files | ||
| Issue | Vol 53, No 4 (2015) | |
| Section | Original Article(s) | |
| Keywords | ||
| Iron-Deficiency Anemia Helicobacter pylori Preschool Children | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
