Case Report

Pleomorphic Sarcoma of Breast: A Report of Two Cases and Review of Literature

Abstract

Sarcomas account for less than 1% of all primary breast malignancies, pleomorphic sarcoma of the breast being even rarer. We present two cases of pleomorphic sarcoma of the breast in a 35-year-old and a 43-year-old female. An extensive review of the available literature with evaluation of the etiology, changing terminologies and histopathologic features of pleomorphic sarcoma of the breast are discussed. The prognostic factors and treatment modalities have also been reviewed.

References

Blanchard DK, Reynolds CA, Grant CS, Donohue JH. Primary nonphylloides breast sarcomas. Am J Surg 2003; 186: 359-361.

Qiu SQ, Wei XL, Huang WH, et al. Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma. Scientific Reports 2013; 3: 2529.

Pollard SG, Marks PV, Temple LN, Thompson HH. Breast sarcoma. A clinicopathologic review of 25 cases. Cancer 1990; 66: 941-944.

O’Brien JE and Stout AP: Malignant fibrous xanthomas. Cancer 1964; 17:1445-1455.

Blanchard DK, Reynolds C, Grant CS, et al. Radiation-induced breast sarcoma. Am J Surg 2002; 184: 356-358.

Sheppard DG and Libshitz HI: Post-radiation sarcomas: a review of the clinical and imaging features in 63 cases. Clin Radiol 2001; 56: 22-29.

Liu Dai-Wei, Hsu Wen-Lin, Hsu Yung-Hsiang, et al. Postirradiation malignant fibrous histiocytoma of the breast: A case report and review of the literature. Therapeut Radiol Oncol 2004; 11(2): 119-126.

Ewertz M, Mouridsen HT. Second cancer following cancer of the female breast in Denmark, 1943-1980. Natl Cancer Inst Monogr 1985; 68: 309-324.

Harvey E, Brinton L. Second cancer following cancer of the breast in Connecticut, 1935-1982. Natl Cancer Inst Monogr 1985; 68: 99-109.

Smith TB, Gilcrease MZ, Santiago L, et al. Imaging features of primary breast sarcoma. AJR Am J Roentgenol 2012;198(4):W386-93.

Weiss SW, Goldblum JR. Malignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma). In: Enzinger and Weiss’s Soft Tissue Tumors. 5th ed. St Louis MO: Mosby; 2008, 177-219.

Fletcher CD. The evolving classification of soft tissue tumours – an update based on the new 2013 WHO classification. Histopathology 2014; 64(1):2-11.

Juan Rosai. Rosai and Ackerman’s Surgical Pathology. 10th ed. Mosby; 2011.

De Cesare, A, Fiori E, Burza A, et al. Malignant fibrous histiocytoma of the breast. Report of two cases and review of the literature. Anticancer Res 2005; 25: 505–08.

Adem C, Reynolds C, Ingle JN, Nascimento AG. Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. British Journal of Cancer 2004; 91(2): 237–241.

Jones, MW, Norris HJ, Wargotz ES, Weiss SW. Fibrosarcoma - malignant fibrous histiocytoma of the breast. A clinicopathological study of 32 cases. Am J Surg Pathol 1992; 16(7): 667–74.

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IssueVol 55, No 4 (2017) QRcode
SectionCase Report(s)
Keywords
Pleomorphic Sarcoma Breast

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Bansal A, Kaur M, Dalal V. Pleomorphic Sarcoma of Breast: A Report of Two Cases and Review of Literature. Acta Med Iran. 2017;55(4):272-276.