Sudden Death Due to Association between NAFLD and Cardiovascular Changes in a 37-Year-Old Man: a Case Report
,
Abstract
Fatty liver disease (FLD) is the most prevalent form of liver disease worldwide. Overnutrition can induce nonalcoholic fatty liver disease (NAFLD), a spectrum of conditions ranging from simple steatosis [or nonalcoholic fatty liver (NAFL)] to nonalcoholic steatohepatitis and cirrhosis. Some of the epidemiological and pathological studies have also suggested an association between the presence of fatty liver and sudden death. A 37-year-old man was found dead when he was asleep in the bed at home. According to his family, he was single and a costermonger. He was not an athlete, and there was no history of any physical and mental disorder. He was not addicted and did not use any drugs or alcohol. The positive points, in this case, were: a large heart with mild coronary stenosis and steatohepatitis in autopsy and sudden death. Since steatohepatitis did not have any complication such as fat embolism, it can be concluded that the combination of steatohepatitis and cardiovascular disorder led to sudden unexpected death. Heart more than 450 gr is susceptible to arrhythmia, and fatty liver disease can cause cardiovascular changes.
Toshikuni N, Fukumura A, Hayashi N, et al . Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension, diabetes mellitus, and dyslipidemia. J Clin Biochem Nutr 2013;52(1):82-8.
Zois CD, Baltayiannis GH, Bekiari A, et al. Steatosis and steatohepatitis in postmortem material from Northwestern Greece.World J Gastroenterol 2010;16( 31):3944-9.
Adler M, Schaffner F. Fatty liver hepatitis and cirrhosis in obese patients. Am J Med 1979;67(5):811-6.
Ludwig J, Viaggiano TR, McGill DB, et al. Nonalcoholic steatohepatitis:Mayo Clinic experience with an hitherto unnamed disease. Mayo ClinProc 1980;55(7):434-8.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary ofthe Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment PanelIII). JAMA 2001;285(19):2486-97.
XU XK. Right ventricular fatty replacement as the possiblemissing link between fatty liver and sudden death. Med Hypotheses Res 2004;1(4):253-60.
Barclay L. Nonalcoholic Steatohepatitis Linked to Increased Mortality. Medscape. (Accessed in May 2015, 10, at http://www.medscape.com/viewarticle/716586).
Stepanova M, Rafig N, Makhlouf H, et al. Predictors of All-Cause Mortality and Liver-Related Mortality in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD). Dig Dis Sci 2013:58(10):3017-23.
Misra VL, Khashab M, Chalasani N. Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk. Curr Gastroenterol Rep 2009;11(1):50-5.
Matteoni CA, Younossi ZM, Gramlich T, et al.Nonalcoholic fatty liver disease: a spectrum of clinicaland pathological severity. Gastroenterology 1999;116(6):1413-9.
Non-alcoholic Fatty Liver Disease. Patient. (Accessed in May 2015, 10, at www.patient.co.uk/health/non-alcoholicfatty-liver-disease).
Saukko P, Knight B, editors. Knight Forensic pathology. 3rd ed. New york: CRC Press; 2004: p. 504-6.
Mohammad Ebrahim Ghamar-Chehreh, Hossein Khedmat, Mohsen Amini, et al. Predictive value of having positive family history of cardiovascular. Disorders, diabetes mellitus, dyslipidemia, and hypertension in non-alcoholic fatty liver disease patients. Acta Med Iran 2013;51(5):307-13.
| Files | ||
| Issue | Vol 54, No 4 (2016) | |
| Section | Case Report(s) | |
| Keywords | ||
| Steatohepatitis Sudden death Cardiovascular | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
