Castleman's Disease: Report of Four Cases and Review of the Literature
Abstract
Castleman’s disease (CD) is a rare benign lymphoproliferative disorder with unknown etiology and pathogenesis. It presents in two identified clinical forms of unicentric or multicentric. The disease is usually found incidentally in the mediastinal or hilar region in asymptomatic patients. In unicentric CD, constitutional symptoms are uncommon, and they can be misdiagnosed as lung infections or malignancy. Although imaging studies are helpful, but definitive diagnosis can be made with pathologic examination. Complete surgical resection is the method of choice for treatment of localized CD, and the prognosis is excellent. In this study, we elucidate clinical features and therapeutic consequences of four cases of unicentric CD referred to our department and review the literature on the diagnosis and management of this relatively rare disorder. Because of the rarity of the disease and nonspecific signs and symptoms of CD it must be considered in differential diagnosis of pulmonary and mediastinal masses.
Saeed-Abdul-Rahman I, Al-Amri AM. Castleman disease. Korean J Hematol 2012;47:163-77.
Castleman B, Towne VW: Records of the MassachusettsGeneral Hospital-weekly clinicopathological exercises(case 40011). N Engl J Med 1954;250:26-30.
Wagner N, Maden Z. An unusual unifocal presentation ofCastleman’s disease in a young woman with a detaileddescription of sonographic findings to reduce diagnosticuncertainty: a case report. BMC Res Notes 2013;6:97.
Momoi A1, Kojima M, Sakai T, Ajiro J, Isahai N, NagaiK, et al. IL-6-positive classical Hodgkin's lymphoma co-occurring with plasma cell type of Castleman's disease:report of a case. Int J Hematol 2013;97:275-9.
Xiao J, Chen LW, Chen W, Zhou LY, Li XF, Chen Y, etal. Clinical characteristics and surgical treatment forlocalized Castleman's disease. Zhonghua Zhong LiuZaZhi 2012;34:61-4.
Rajabiani A, Abdollahi A, Farahani Z. AsymptomaticIsolated Retroperitoneal Castleman's Disease: A CaseReport. Iran J Med Sci 2015;40:469-72.
Sudha A, Vivekanand N. Cytologic picture ofCastleman's disease: A report of two cases. J Cytol2010;27:152-4.
Halac M, Ergul N, Sager S, Demir A, Buyukpinarbasli N,Sonmezoglu K. PET/CT findings in a multicentric formof Castleman's disease. Hell J Nucl Med 2007;1:172-4.
Chen CH, Liu HC, Tung KY, Lee JJ, Liu CL, Liu TP.Surgical outcome of superficial and deep Castlemandisease. ANZ J Surg 2007;77:339-43.
Barua A, Vachlas K, Milton R, Andrew J, Thorpe C.Castleman’s disease- a diagnostic dilemma. JCardiothorac Surg 2014; 19:170
Baranzelli A, Akkad R, Bouchindhomme B, Tacelli N,Delourme J, Dhalluin X, et al. Castleman's disease:unusual presentation of Castleman's disease and review ofliterature. Rev Pneumol Clin 2013;69:55-9.
Haque S, van Kirk R. Three patients with both odgkin'slymphoma and Castleman's disease: Clinicopathologiccorrelations and lack of association with HHV-8. Indian JMed Paediatr Oncol 2009;30:76-9.
Pinheiro VG, Fernandes GH, Cezar LC, AlvesNde A, deMenezes DB. Castleman's disease accompanied bypleural effusion. J Bras Pneumol 2008;34:626-30
Akosmana C, Alan Selcukb N, Ordua C, Ercanc S,DoganEkicidI, OyanaB. Unicentric mixed variantCastleman disease associated with Hashimoto disease: therole of PET/CT in staging and evaluating response to thetreatment. Cancer Imaging 2011;11:52-5.
Uskül B, Ertuğrul M, Selvi A, Mihmanli A, Zindanci I,Türker H. A rare association: Castleman's disease andpemphigus vulgaris. Tuberk Toraks 2005;53:172-6.
Dinesha, Padyana M, Nayak K, Nirupama M, ShivanandPia D. Castleman's Disease with ParaneoplasticPemphigus. Indian J Dermatol 2014;59:421.
Shahidi H, Myers JL, Kvale PA. Castleman's disease.Mayo Clin Proc 1995;70:969-77.
Alavi A, AsadiGharabaghi M. Unicentric Castleman’sdisease: an uncommon cause of posterior mediastinalmass. BMJ Case Rep 2013;2013:bcr2012008522.
Ota H, Kawai H, Matsuo T. Unicentric Castleman’sdisease arising from an intrapulmonary lymph node. CaseRep Surg 2013;2013:289089.
Rawashdeh B, Meyer M, Yimin D, Anthony C, NguyenD, Moslemi M, et al. Unicentric Castleman’s DiseasePresenting as a Pulmonary Mass: A Diagnostic Dilemma.Am J Case Rep 2015;16:259-61.
Gunluoglu G, Olcmen A, Nedime Sokucu S, Akin H,Dincer I. Intrapulmonary-located castleman’s disease,which was surgically resected without pulmonaryresection. Ann Thorac Cardiovasc Surg 2011;17:580-3.
Nadir A, Colak N, Koktener A, Yildirim U. Isolatedintrapulmonary Castleman's disease: a case report, reviewof the literature. Ann Thorac Cardiovasc Surg2014;20:689-91.
Jongsma TE, Verburg RJ, Geelhoed-Duijvestijn PH.Castleman's disease: A rare lymphoproliferative disorder.Eur J Intern Med 2007;18:87-9.
Ma SH, Liu QJ, Zhang YC, Yang R. Diagnosis andsurgical treatment of Castleman's disease. Zhonghua YiXue Za Zhi 2011;91:1118-21.
Keller AR, Hochholzer L, Castleman B. Hyaline-vascularand plasma-cell types of giant lymph node hyperplasia ofthe mediastinum and other locations. Cancer1972;29:670-83.
Suh JH, Hong S H, Jeong SC, Park CB, Choi KB, ShinOR, Choi SY. Anemia resolved by thoracoscopicresection of a mediastinal mass: a case report ofunicentric Castleman’s disease. J Thorac Dis. 2015;7(7):189-193
Mohammed A, Janku F, Qi M,Kurzrock R. Castleman’sdisease and sarcoidosis, a rareassociation resulting in a“mixed” response:a case report. J Med Case Rep2015;9:45.
Racil H, CheikhRouhou S, Ismail O, Hantous-Zannad S,Chaouch N, Zarrouk M, Smati B, Mezni F, Chabbou A.Castleman's disease: an intrapulmonary form withintrafissural development. Sci World J 2009;9:940-5.
Amano Y, Takai D, Ohishi N, Shinozaki-Ushiku A,Fukayama M, Akahane M, et al. Successful Treatment ofMediastinal Unicentric Castleman's Disease Using Video-Assisted Thoracoscopic Surgery with PreoperativeEmbolization.Case Rep Med 2013;2013:354507.
Aydemir B, Okay T, Imamoglu O, Sahin S, Dogusoy I.Preoperative embolization in mediastinal Castleman'sdisease. Thorac Cardiovasc Surg 2010;58:496-8.
Dham A, Peterson BA: Castleman disease. Curr OpinHematol 2007;14:354-9
| Files | ||
| Issue | Vol 56, No 2 (2018) | |
| Section | Case Report(s) | |
| Keywords | ||
| Castleman's disease Lymphoproliferative disorder Surgical resection | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
