Case Report

Trousseau´s Syndrome Mimicking Severe Bilateral Peripheral Arterial Disease

Abstract

We present the case of how a massive proximal deep vein thrombosis result of an unknown recurrence of a previously colonic malignancy treated, classically known Trousseau´s Syndrome, can mimic symptoms of severe peripheral arterial disease in a patient affected of peripheral chronic arterial disease surgically treated. Trousseau´s Syndrome is commonly associated with serious and chronic diseases and a variety of paraneoplastic thromboembolic disorders. Thrombotic episodes may precede the diagnosis of cancer and be the potential marker for an unknown and occult malignancy. We highlight the key points of the Trousseau´Syndrome and those paraneoplastic vasculopathies related that can mimic a vascular disease or complication.

. Galanaud JP, Sevestre-Pietri MA, Bosson JL, et al. Comparative study on risk factors and early outcome of symptomatic distal versus proximal deep vein thrombosis: results from the OPTIMEV study. Thromb Haemost 2009; 102:493.

. Pérez G, Rodríguez AM, Ballesteros M, Infante ME, Inigo B. Enfermedad tromboembólica en el paciente oncológico. La enfermedad tromboembólica venosa (ETV) en el paciente médico. Madrid: THink-In Pharma Services, S. L.; 2011. P. 140-71.

. Goldsmith GH Jr. Hemostatic disorders associated with neoplasia. Forbes CD, Ratnoff OD, editors. Disorders of hemostasis. Philadelphia: Grune & Stratton, 1984:351-66.

. Trousseau A. Phlegmasia alba dolens. Clinique Medicale de I'Hotel-Dieu de Paris. Volume 3. London: New Sydenham Society, 1865:695 - 727.

. Edwards EA. Migratory thrombophlebitis associated with carcinoma. N Engl J Med 1947;240:1031-4.

. Lieberman JS, Borrero J, Urrdeaneta E, Wright IS. Thrombophlebitis and cancer. JAMA 1961; 177:542-5.

. Nussbacher J. Migratory venous thrombosis of legs. N YStute J Med 1964; 642 166-73.

. Gore JM, Appelbaum JS, Greene HL, Dexter L, Dalen JE. Occult cancer in patients with deep venous thrombosis. Arch Intern Med 1987; 147:556-60.

. Goldberg RJ, Seneff M, Gore JM. Occult malignant neoplasm in patients with deep venous thrombosis. Arch Intern Med 1987; 1471251-3.

. Griffin MR, Stanson AW, Brown ML, et al. Deep venous thrombosis and pulmonary embolismr:i sk of subsequent malignant neoplasia. Arch Intern Med 1987; 147:1907-11.

. Naschitz JE, Yeshurun D, Gaitini D. Deep venous leg thrombosis and its differential diagnosis: the case for B-mode ultrasonography. Int 1 Angiology 1993; 1:218-24.

. Chaikoff EL, Campbell BE, Smith RB 3d. Paradoxical embolis and acute arterial occlusion: rare or unsuspected? / Vusc Surg 1994; 20:377-84.

. Sierra-Montenegro E, Sierra-Luzuriaga G, Calle-Loffredo D, Rodríguez Quinde M. Rectal cancer and Trousseau syndrome. Case report. Cir Cir. 2013 May-Jun;81(3):242-5.

. Mezouar S, Mege D, Darbousset R, et al. Involvement of platelet-derived microparticles in tumor progression and thrombosis. Semin Oncol. 2014 Jun;41(3):346-58.

. Naschitz JE, Schechter L, Chang JB. Intermittent claudication associated with cancer-case studies. Angiology 1987; 9: 696-704.

. Naschitz J, Yeshurun D, Abrahamson J, et al. Ischemic heart disease precipitated by occult cancer. Concer 1992;69:2712-20.

. Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (9th edition). Chest 2012;141:419S-94 S.

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IssueVol 56, No 6 (2018) QRcode
SectionCase Report(s)
Keywords
Peripheral arterial disease Deep venous thrombosis Cancer Syndrome of trousseau
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Gil-Ongay A, Elena Arnáiz-García M, Blanco-Castillo C, Pulitani I, González-Santos JM, Arnáiz-García AM. Trousseau´s Syndrome Mimicking Severe Bilateral Peripheral Arterial Disease. Acta Med Iran. 2018;56(6):415-418.