Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’s Disease

  • Javad Fahanik-Babaei Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Tourandokht Baluchnejadmojarad Mail Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Farnaz Nikbakht Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Mehrdad Roghani Neurophysiology Research Center, Shahed University, Tehran, Iran.
Trigonelline, Alzheimer’s disease, Amyloid β, Learning and memory, Synaptic plasticity, Long-term potentiation


- Intrahippocampal amyloid β (Aβ) negatively affects synaptic plasticity with subsequent impairment
of learning and memory. Trigonelline is an alkaloid commonly found in fenugreek seeds and coffee beans with
neuroprotective property and a promising agent for management of neurodegenerative disorders like
Alzheimer’s disease (AD). In the present study, the possible beneficial effect of trigonelline on the improvement
of learning and memory and synaptic plasticity was evaluated in Aβ (1-40) rat model of AD. For modeling AD,
aggregated A


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How to Cite
Fahanik-Babaei J, Baluchnejadmojarad T, Nikbakht F, Roghani M. Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’s Disease. Acta Med Iran. 56(10):625-634.