Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’s Disease
,
Abstract
- Intrahippocampal amyloid β (Aβ) negatively affects synaptic plasticity with subsequent impairment
of learning and memory. Trigonelline is an alkaloid commonly found in fenugreek seeds and coffee beans with
neuroprotective property and a promising agent for management of neurodegenerative disorders like
Alzheimer’s disease (AD). In the present study, the possible beneficial effect of trigonelline on the improvement
of learning and memory and synaptic plasticity was evaluated in Aβ (1-40) rat model of AD. For modeling AD,
aggregated A
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| Issue | Vol 56, No 10 (2018) | |
| Section | Original Article(s) | |
| Keywords | ||
| Trigonelline Alzheimer’s disease Amyloid β Learning and memory Synaptic plasticity Long-term potentiation | ||
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