Articles

Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Abstract

The human T cell lymphotropic virus type-1 (HTLV-1) is associated with adult T cell leukemia/lymphoma (ATL) and other disorders, including a slowly progressive demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Dermatologic manifestations are common in patients infected with HTLV-1 infection. In this study, we evaluated the dermatologic lesions associated with HAM/TSP patients in Mashhad, Iran. Dermatological findings of 37 patients with HAM/TSP were investigated and compared with those of an HTLV-1 negative control group. A cutaneous biopsy was performed as needed, and the results were statistically analyzed. Results of the present study showed that 34 cases with HAM/TSP (91.9%) and 24 cases in the control group (64.9%) had at least one skin lesion or history of skin lesion before (P=0.010). Xerosis was found in 22 persons (59.5%) in the case group and 4 persons in the control group (10.8%) (P=0.000). Only xerosis was significantly associated with HAM/TSP. Skin manifestations were quite frequent in patients with HAM/TSP. Xerosis was significantly associated with HAM/TSP.

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IssueVol 57, No 3 (2019) QRcode
SectionArticles
DOI https://doi.org/10.18502/acta.v57i3.1821
Keywords
HTLV-1 HTLV-1 associated myelopathy (HAM) Tropical spastic paraparesis (TSP) Skin lesions
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Boostani R, Layegh P, Yazdanpanah MJ, Vosoughi E, Mohammadi A, Joneidi N, Bazargani R, Sayadpour Zanjani D, Ebrahimzadeh S. Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. Acta Med Iran. 2019;57(3):180-183.