A Pilot Study on Correlation Between Serum Selenium and Copper Concentrations and Coronary Slow Flow Phenomenon

  • Mostafa Dastani Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Soheila Moshiri Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ramin Khameneh Bagheri Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Maryam Bahramizadeh Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ladan Hassanzadeh Khayyat School of Medicine, St. George’s University, Grenada, USA.
  • Sepideh Elyasi Mail Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Amir Hooshang Mohammadpour Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. AND Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Keywords:
Selenium, Copper, Coronary slow flow phenomenon, Microvascular angina

Abstract

The pathophysiology of coronary arteries slow flow phenomenon is related to the microvascular and endothelial disorder. The role of copper and selenium in the development of microvascular and endothelial disorders, as well as atherosclerosis, has been proven in previous studies. The aim of this study was to evaluate the serum copper and selenium concentrations in patient with coronary slow flow phenomenon to find a probable relationship between them. In this study, 125 patients who referred to Ghaem Hospital in Mashhad for angiography were selected based on entry and exit criteria. Patients were divided into 5 groups according to the results of angiography. Blood samples of these patients were evaluated about the levels of copper and selenium. Finally the correlation between these levels and the intensity of coronary arteries slow flow (based on TIMI scores) was evaluated. In the present study, serum selenium and copper concentrations did not show a significant correlation with the intensity of coronary arteries slow flow (P>0.05). In the present study, no significant correlation was found between copper and selenium serum concentrations and coronary arteries slow flow based on TIMI. Further studies are recommended to investigate this association.

 

References

analysis. Am J Clin Nutr 2006;84:762-73.
23. Rukgauer M, Klein J, Kruse-Jarres JD, Reference values for the trace elements copper, manganese, selenium, and zinc in the serum/plasma of children, adolescents, and adults. J trace elem med bio 1997;11:92-98.
24. Safaralizadeh R, Kardar GA, Pourpak Z, Moin M, Zare A, Teimourian S, Serum concentration of selenium in healthy individuals living in Tehran. Nutr j 2005;4:1-4.
25. Benstoem C, Goetzenich A, Kraemer S, Borosch S, Manzanares W, Hardy G, et al, Selenium and its supplementation in cardiovascular disease--what do we know? Nutrients 2015;7:3094-3118.
26. Yuan Y, Xiao Y, Feng W, Liu Y, Yu Y, Zhou L, et al, Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort. Environ Health Perspect 2017;125:1-10.
27. Ju W, Li X, Li Z, Wu GR, Fu XF, Yang XM, et al, The
effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials. J trace elem med bio 2017;44:8-16.
28. Zhang X, Liu C, Guo J, Song Y, Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials. Eur j clin nutr 2016;70:162-9.
29. Klevay LM, IHD from copper deficiency: a unified theory. Nutr res rev 2016;29:172-79.
30. Bagheri B, Akbari N, Tabiban S, Habibi V, Mokhberi V, Serum level of copper in patients with coronary artery disease. Nigerian med j 2015;56:39-42.
31. Lutfi MF, Elhakeem RF, Khogaly RS, Abdrabo AA, Ali AB, Gasim GI, et al, Zinc and copper levels are not correlated with angiographically-defined coronary artery disease in sudanese patients. Front physiol 2015;6:1-4.
Published
2019-11-17
How to Cite
1.
Dastani M, Moshiri S, Khameneh Bagheri R, Bahramizadeh M, Hassanzadeh Khayyat L, Elyasi S, Mohammadpour AH. A Pilot Study on Correlation Between Serum Selenium and Copper Concentrations and Coronary Slow Flow Phenomenon. Acta Med Iran. 57(6):374-380.
Section
Articles