Review Article

Study of Genome, Vaccine and Probable Anti Viral Drugs to Save the World From the Capture of SARS-CoV-2: A Mini-Review


The coronavirus disease 2019 (COVID-19) is a single-stranded RNA (+) virus and causes infectious disease by the viral strain "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). Now, COVID-19 has become pandemic, and there are neither potential vaccines nor drugs discovered. Its RNA contains genes for structural (S, E, M, N) and non-structural proteins (PLpro, 3CLpro, RdRp, Hel). Interaction between the S protein of SARS-CoV-2 and the ACE 2 receptor of the host cell plays a vital role in the entry of the virus into the cell. Favipiravir, ribavirin, remdesivir, galidesivir, lopinavir, ritonavir, chloroquine, and hydroxychloroquine are the few effective drugs against SARS-CoV-2. Live attenuated virus (mutant MERS-CoV and SARS-CoV or recombination with another live attenuated virus) can act as vaccine platforms against SARS CoV-2 along with DNA vaccine and subunit vaccine.

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IssueVol 60, No 4 (2022) QRcode
SectionReview Article(s)
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Chloroquine Spike protein Angiotensin-converting enzyme 2 (ACE 2) receptor Pandemic

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How to Cite
Kumar Pradhan A, Arakha M, Kumar Sahoo B, Bhattacharya D. Study of Genome, Vaccine and Probable Anti Viral Drugs to Save the World From the Capture of SARS-CoV-2: A Mini-Review. Acta Med Iran. 2022;60(4):202-209.