Isolated Mediastinal Langerhans Cell Histiocytosis in a 7-Year-Old Child
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Abstract
We describe the case of a 7-year-old boy who presented with suprasternal swelling. The chest computed tomography scan showed a large mass of mediastinum. Biopsy from the mediastinal mass was performed. Histologic and immunohistochemistry findings were consistent with Langerhans cell histiocytosis [LCH]. LCH should also be considered in the differential diagnosis of anterior mediastinal tumor in children.
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2. Collin M, Bigley V, McClain K, Allen CE. Cell(s) of Origin of Langerhans Cell Histiocytosis. Hematol Oncol Clin North Am 2015;29:825-38.
3. Ansari S, Miri-Aliabad G, Arjmandi-Rafsanjani K. Results of Treatment with 2-Chlorodeoxyadenosine (2- CDA) in Multiple Reactivations or Refractory Langerhans Cell Histiocytosis. Zahedan J Res Med Sci (ZJRMS) 2014;16:89-92.
4. Allen CE, Merad M, McClain KL. Langerhans-Cell Histiocytosis. N Engl J Med 2018;379:856-68.
5. Picarsic J, Egeler RM, Chikwava K, Patterson K, Jaffe R. Histologic patterns of thymic involvement in Langerhans
cell proliferations: a clinicopathologic study and review of the literature. Pediatr Deve Pathol 2015;18:127-38.
6. Khadilkar UN, Rao AT, Sahoo KK, Pai MR. Langerhans cell histiocytosis of mediastinal node. Indian J Pediatr
2008;75:294-6.
7. Ramzan M, Yadav SP. Langerhans cell histiocytosis presenting as isolated mediastinal mass in an infant.Indian Pediatr 2014;51:397-8.
8. Ducassou S, Seyrig F, Thomas C, Lambilliotte A, Marec- Berard P, Berger C, et al. Thymus and mediastinal node
invovement in childhood Langerhnas cell histiocytosis: long-term follow-up form the French National Cohort.
Pediatr Blood Cancer 2013;60:1759-65.
9. Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest 2005;128:2893-909.
10. Fahrner R, Hoksch B, Gugger M, Schmid RA. Langerhans cell histiocytosis as differential diagnosis of a mediastinal tumor. Eur J Cardiothorac Surg 2008;33:516-17.
11. Hernandez Perez JM, Franquet CT, Rodriguez S, Giminez A. The langerhans cell histiocytosis with thymic localization as initial and exclusive place. An Med Interna 2007;24:497-9.
| Files | ||
| Issue | Vol 60, No 2 (2022) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/acta.v60i2.8825 | |
| Keywords | ||
| Mediastinal mass Langerhans cell histiocytosis Children | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Miri-Aliabad G, Dahmardeh H, Rajabi MS. Isolated Mediastinal Langerhans Cell Histiocytosis in a 7-Year-Old Child. Acta Med Iran. 2022;60(2):129-131.
