Tuberculosis Uveitis Associated With Ocular Surface Squamous Neoplasia in an Otherwise Healthy Patient
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Abstract
We describe a 34-year-old woman with isolated tuberculosis (TB) uveitis who had unsuccessful resolution of her ocular surface squamous neoplasia after multiple shave excisions with a positive purified protein derivative (PPD) test and interferon-gamma (IFN-γ) release assays (IGRAs) proven tuberculosis. She was managed with wide local excision of the lesion. Histopathology confirmed conjunctival intraepithelial neoplasia (CIN) grade II. Topical interferon alpha-2b (4 times daily) and anti-tuberculous therapy was planned for her, and there was no sign of recurrence of the lesion at six months follow-up.
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9. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology 1997;104:485-92.
10. Al Bayyat G, Arreaza-Kaufman D, Venkateswaran N, Galor A, Karp CL. Update on pharmacotherapy for ocular surface squamous neoplasia. Eye Vis 2019;6:1-12.
2. Kiire C, Dhillon B. The aetiology and associations of conjunctival intraepithelial neoplasia. Br J Ophthalmol 2006;90:109-13.
3. Meel R, Dhiman R, Vanathi M, Pushker N, Tandon R, Devi S. Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia. Indian J Ophthalmol 2017;65:936-41.
4. Acharya N, Ramappa R, Thomas RK. Clinical profile of Ocular Surface Squamous Neoplasia: a retrospective case series. J Evol Med Dent Sci 2016;5:1100-3.
5. Meel R, Dhiman R, Sen S, Kashyap S, Tandon R, Vanathi M. Ocular Surface Squamous Neoplasia with Intraocular Extension: Clinical and Ultrasound Biomicroscopic Findings. Ocul Oncol Pathol 2019;5:122-7.
6. Saini AK, Maithal K, Chand P, Chowdhury S, Vohra R, Goyal A, et al., Nuclear localization and in situ DNA damage by Mycobacterium tuberculosis nucleoside-diphosphate kinase. J Biol Chem 2004;279:50142-9.
7. Shin DM, Yang CS, Lee JY, Lee SJ, Choi HH, Lee HM, et al. Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages. Cell Microbiol 2008;10:1893-1905.
8. Zhang J, Jiang R, Takayama H, Y Tanaka Y. Survival of virulent Mycobacterium tuberculosis involves preventing apoptosis induced by Bcl‐2 upregulation and release resulting from necrosis in J774 macrophages. Microbiol Immunol 2005;49:845-52.
9. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology 1997;104:485-92.
10. Al Bayyat G, Arreaza-Kaufman D, Venkateswaran N, Galor A, Karp CL. Update on pharmacotherapy for ocular surface squamous neoplasia. Eye Vis 2019;6:1-12.
| Files | ||
| Issue | Vol 59, No 2 (2021) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/acta.v59i2.5580 | |
| Keywords | ||
| Ocular surface squamous neoplasia Tuberculosis Uveitis | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Aghaei H, Es’haghi A, Alilou S, Rafatnia S. Tuberculosis Uveitis Associated With Ocular Surface Squamous Neoplasia in an Otherwise Healthy Patient. Acta Med Iran. 2021;59(2):122-124.
